UCSF

Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human (8 Compounds)

Swissprot:
PP1A_HUMAN
Stitch:
PP1A_HUMAN
UniProt:
P62136
ChEMBL:
CHEMBL2164
Reactome:
REACT_15334
REACT_120727
REACT_494
PDB:
3E7A (DOCK)
3E7B (DOCK)
3EGG (DOCK)
3EGH (DOCK)
3HVQ (DOCK)
3N5U (DOCK)
PPP1CA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 8 3 1 1
Binding ≤ 1μM 4 3 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_15334 DARPP-32 events Homo sapiens
REACT_120727 Downregulation of TGF-beta receptor signaling Homo sapiens
REACT_494 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 1
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 2

Downregulation of TGF-beta receptor signaling

Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 8

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 8

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PP1A-1-E Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit (cluster #1 Of 2), Eukaryotic 7 3 1 1
PP1A-2-E Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit (cluster #2 Of 2), Eukaryotic 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 8
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 4
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 2
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 2
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 1
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1
2ABG_HUMAN Q9Y2T4 CHEMBL2507 Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human 1
DUS3_HUMAN P51452 CHEMBL2635 Dual Specificity Protein Phosphatase 3, Human 1
PP2AA_BOVIN P67774 CHEMBL3862 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 1
PP2AA_MOUSE P63330 CHEMBL2451 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse 1
PPAC_HUMAN P24666 CHEMBL4903 Low Molecular Weight Phosphotyrosine Protein Phosphatase, Human 1
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 1
PPM1J_MOUSE Q149T7 CHEMBL2776 Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse 1
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 1
PTPA_HUMAN Q15257 CHEMBL2505 Protein Phosphatase 2A Regulatory Subunit B', Human 1