ZINC 12

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Names
Compounds (23)
Reactome (29)
Related By:
Pathway (6)
Organism (2)
Gene (0)
Org. Clust. (0)
ChEMBL (12)
Rings (0)

Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human (23 Compounds)

Swissprot:: PP2AA_HUMAN
Stitch:: PP2AA_HUMAN
UniProt:: P67775
ChEMBL:: CHEMBL4703
Reactome:: REACT_228196; REACT_228285; REACT_11065; REACT_19405; REACT_1857; REACT_821; REACT_15334; REACT_11063; REACT_200610; REACT_12599; REACT_12436; REACT_1383; REACT_329; REACT_160242; REACT_1505; REACT_150182; REACT_228314; REACT_682; REACT_75822; REACT_23879; REACT_705; REACT_150425; REACT_228159; REACT_228251; REACT_228137; REACT_150471; REACT_111080; REACT_228261; REACT_228060
PDB:: 2IAE (DOCK); 2IE3 (DOCK); 2IE4 (DOCK); 2NPP (DOCK); 2NYL (DOCK); 2NYM (DOCK); 3C5W (DOCK); 3DW8 (DOCK); 3FGA (DOCK); 3K7V (DOCK); 3K7W (DOCK); 3P71 (DOCK); PPP2CA

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	23	9	1	1
Binding ≤ 1μM	3	1	1	1

Reactome ID	Description	Species
REACT_228196	APC truncation mutants have impaired AXIN binding	Homo sapiens
REACT_228285	AXIN missense mutants destabilize the destruction complex	Homo sapiens
REACT_11065	Beta-catenin phosphorylation cascade	Homo sapiens
REACT_19405	CTLA4 inhibitory signaling	Homo sapiens
REACT_1857	Cyclin A/B1 associated events during G2/M transition	Homo sapiens
REACT_821	Cyclin D associated events in G1	Homo sapiens
REACT_15334	DARPP-32 events	Homo sapiens
REACT_11063	Degradation of beta-catenin by the destruction complex	Homo sapiens
REACT_200610	disassembly of the destruction complex and recruitment of AXIN to the membrane	Homo sapiens
REACT_12599	ERK/MAPK targets	Homo sapiens
REACT_12436	ERKs are inactivated	Homo sapiens
REACT_1383	Glycolysis	Homo sapiens
REACT_329	Inhibition of replication initiation of damaged DNA by RB1/E2F1	Homo sapiens
REACT_160242	Initiation of Nuclear Envelope Reformation	Homo sapiens
REACT_1505	Integration of energy metabolism	Homo sapiens
REACT_150182	MASTL Facilitates Mitotic Progression	Homo sapiens
REACT_228314	misspliced GSK3beta mutants stabilize beta-catenin	Homo sapiens
REACT_682	Mitotic Prometaphase	Homo sapiens
REACT_75822	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Homo sapiens
REACT_23879	Platelet sensitization by LDL	Homo sapiens
REACT_705	PP2A-mediated dephosphorylation of key metabolic factors	Homo sapiens
REACT_150425	Resolution of Sister Chromatid Cohesion	Homo sapiens
REACT_228159	S33 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228251	S37 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228137	S45 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_150471	Separation of Sister Chromatids	Homo sapiens
REACT_111080	Spry regulation of FGF signaling	Homo sapiens
REACT_228261	T41 mutants of beta-catenin aren't phosphorylated	Homo sapiens
REACT_228060	truncations of AMER1 destabilize the destruction complex	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

AXIN missense mutants destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Beta-catenin phosphorylation cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

CTLA4 inhibitory signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Cyclin A/B1 associated events during G2/M transition

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Cyclin D associated events in G1

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

DARPP-32 events

Uniprot	Swissprot	Chembl	Description	Number Shared
PP1A_HUMAN	P62136	CHEMBL2164	Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human	1
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Degradation of beta-catenin by the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

ERK/MAPK targets

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

ERKs are inactivated

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Glycolysis

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Integration of energy metabolism

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

MASTL Facilitates Mitotic Progression

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Mitotic Prometaphase

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Platelet sensitization by LDL

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

PP2A-mediated dephosphorylation of key metabolic factors

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Resolution of Sister Chromatid Cohesion

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S33 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S37 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

S45 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Separation of Sister Chromatids

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

Spry regulation of FGF signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

T41 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

truncations of AMER1 destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PP2AA_BOVIN	P67774	CHEMBL3862	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin	5	0	0	0
PP2AA_MOUSE	P63330	CHEMBL2451	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse	3	2	2	1

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	21
2ABG_HUMAN	Q9Y2T4	CHEMBL2507	Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human	21
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	21
PTPA_HUMAN	Q15257	CHEMBL2505	Protein Phosphatase 2A Regulatory Subunit B', Human	21
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1
PP1A_HUMAN	P62136	CHEMBL2164	Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human	1
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_MOUSE	P63330	CHEMBL2451	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse	1
PPM1B_HUMAN	O75688	CHEMBL2845	Protein Phosphatase 2C Beta, Human	1
PPM1J_MOUSE	Q149T7	CHEMBL2776	Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse	1
PTN1_HUMAN	P18031	CHEMBL335	Protein-tyrosine Phosphatase 1B, Human	1
Q8AWE3_CHICK	Q8AWE3	CHEMBL2669	Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick	1

Synonyms
Compounds (23)
Related By:
Pathway (6)
Organism (2)
Gene (0)
ChEMBL (12)
Org. Clust. (0)
Rings (0)

ZINC 12

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Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human (23 Compounds)

Compound Summary

Reactome Network (29)

Related Targets

APC truncation mutants have impaired AXIN binding

AXIN missense mutants destabilize the destruction complex

Beta-catenin phosphorylation cascade

CTLA4 inhibitory signaling

Cyclin A/B1 associated events during G2/M transition

Cyclin D associated events in G1

DARPP-32 events

Degradation of beta-catenin by the destruction complex

disassembly of the destruction complex and recruitment of AXIN to the membrane

ERK/MAPK targets

ERKs are inactivated

Glycolysis

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Integration of energy metabolism

MASTL Facilitates Mitotic Progression

misspliced GSK3beta mutants stabilize beta-catenin

Mitotic Prometaphase

Platelet sensitization by LDL

PP2A-mediated dephosphorylation of key metabolic factors

Resolution of Sister Chromatid Cohesion

S33 mutants of beta-catenin aren't phosphorylated

S37 mutants of beta-catenin aren't phosphorylated

S45 mutants of beta-catenin aren't phosphorylated

Separation of Sister Chromatids

Spry regulation of FGF signaling

T41 mutants of beta-catenin aren't phosphorylated

truncations of AMER1 destabilize the destruction complex

By Organism (2)

Clustered By Gene (0)

By Shared ChEMBL Annotated Substances