ZINC 12

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Names
Compounds (3)
Reactome (28)
Related By:
Pathway (1)
Organism (2)
Gene (0)
Org. Clust. (0)
ChEMBL (12)
Rings (0)

Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse (3 Compounds)

Swissprot:: PP2AA_MOUSE
Stitch:: PP2AA_MOUSE
UniProt:: P63330
ChEMBL:: CHEMBL2451
Reactome:: REACT_230286; REACT_252458; REACT_218396; REACT_261568; REACT_206803; REACT_258573; REACT_203795; REACT_203336; REACT_216784; REACT_215063; REACT_210064; REACT_232322; REACT_208887; REACT_210180; REACT_217323; REACT_196577; REACT_261276; REACT_256756; REACT_198528; REACT_245985; REACT_198961; REACT_260752; REACT_234076; REACT_248000; REACT_207679; REACT_198526; REACT_258576; REACT_250714
PDB:: Ppp2ca

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	3	2	2	1
Binding ≤ 1μM	3	2	2	1

Reactome ID	Description	Species
REACT_230286	APC truncation mutants have impaired AXIN binding	Mus musculus
REACT_252458	AXIN missense mutants destabilize the destruction complex	Mus musculus
REACT_218396	Beta-catenin phosphorylation cascade	Mus musculus
REACT_261568	CTLA4 inhibitory signaling	Mus musculus
REACT_206803	Cyclin A/B1 associated events during G2/M transition	Mus musculus
REACT_258573	Cyclin D associated events in G1	Mus musculus
REACT_203795	DARPP-32 events	Mus musculus
REACT_203336	Degradation of beta-catenin by the destruction complex	Mus musculus
REACT_216784	disassembly of the destruction complex and recruitment of AXIN to the membrane	Mus musculus
REACT_215063	ERK/MAPK targets	Mus musculus
REACT_210064	ERKs are inactivated	Mus musculus
REACT_232322	Glycolysis	Mus musculus
REACT_208887	Inhibition of replication initiation of damaged DNA by RB1/E2F1	Mus musculus
REACT_210180	Initiation of Nuclear Envelope Reformation	Mus musculus
REACT_217323	Integration of energy metabolism	Mus musculus
REACT_196577	MASTL Facilitates Mitotic Progression	Mus musculus
REACT_261276	misspliced GSK3beta mutants stabilize beta-catenin	Mus musculus
REACT_256756	Mitotic Prometaphase	Mus musculus
REACT_198528	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Mus musculus
REACT_245985	PP2A-mediated dephosphorylation of key metabolic factors	Mus musculus
REACT_198961	Resolution of Sister Chromatid Cohesion	Mus musculus
REACT_260752	S33 mutants of beta-catenin aren't phosphorylated	Mus musculus
REACT_234076	S37 mutants of beta-catenin aren't phosphorylated	Mus musculus
REACT_248000	S45 mutants of beta-catenin aren't phosphorylated	Mus musculus
REACT_207679	Separation of Sister Chromatids	Mus musculus
REACT_198526	Spry regulation of FGF signaling	Mus musculus
REACT_258576	T41 mutants of beta-catenin aren't phosphorylated	Mus musculus
REACT_250714	truncations of AMER1 destabilize the destruction complex	Mus musculus

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

AXIN missense mutants destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Beta-catenin phosphorylation cascade

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

CTLA4 inhibitory signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Cyclin A/B1 associated events during G2/M transition

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Cyclin D associated events in G1

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

DARPP-32 events

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Degradation of beta-catenin by the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

ERK/MAPK targets

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

ERKs are inactivated

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Glycolysis

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Initiation of Nuclear Envelope Reformation

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Integration of energy metabolism

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

MASTL Facilitates Mitotic Progression

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Mitotic Prometaphase

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

PP2A-mediated dephosphorylation of key metabolic factors

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Resolution of Sister Chromatid Cohesion

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

S33 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

S37 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

S45 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Separation of Sister Chromatids

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

Spry regulation of FGF signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

T41 mutants of beta-catenin aren't phosphorylated

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

truncations of AMER1 destabilize the destruction complex

Uniprot	Swissprot	Chembl	Description	Number Shared
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PP2AA_BOVIN	P67774	CHEMBL3862	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin	5	0	0	0
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	23	9	1	1

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
PP2AB_HUMAN	P62714	CHEMBL2435	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human	3
PPM1J_MOUSE	Q149T7	CHEMBL2776	Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse	3
2A5A_HUMAN	Q15172	CHEMBL4763	Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human	1
2AAA_MOUSE	Q76MZ3	CHEMBL3557	Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse	1
2ABG_HUMAN	Q9Y2T4	CHEMBL2507	Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human	1
PP1A_HUMAN	P62136	CHEMBL2164	Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human	1
PP1G_HUMAN	P36873	CHEMBL4438	Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human	1
PP2AA_HUMAN	P67775	CHEMBL4703	Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human	1
PPM1B_HUMAN	O75688	CHEMBL2845	Protein Phosphatase 2C Beta, Human	1
PTN1_HUMAN	P18031	CHEMBL335	Protein-tyrosine Phosphatase 1B, Human	1
PTPA_HUMAN	Q15257	CHEMBL2505	Protein Phosphatase 2A Regulatory Subunit B', Human	1
Q8AWE3_CHICK	Q8AWE3	CHEMBL2669	Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick	1

Synonyms
Compounds (3)
Related By:
Pathway (1)
Organism (2)
Gene (0)
ChEMBL (12)
Org. Clust. (0)
Rings (0)

ZINC 12

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Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse (3 Compounds)

Compound Summary

Reactome Network (28)

Related Targets

APC truncation mutants have impaired AXIN binding

AXIN missense mutants destabilize the destruction complex

Beta-catenin phosphorylation cascade

CTLA4 inhibitory signaling

Cyclin A/B1 associated events during G2/M transition

Cyclin D associated events in G1

DARPP-32 events

Degradation of beta-catenin by the destruction complex

disassembly of the destruction complex and recruitment of AXIN to the membrane

ERK/MAPK targets

ERKs are inactivated

Glycolysis

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Initiation of Nuclear Envelope Reformation

Integration of energy metabolism

MASTL Facilitates Mitotic Progression

misspliced GSK3beta mutants stabilize beta-catenin

Mitotic Prometaphase

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

PP2A-mediated dephosphorylation of key metabolic factors

Resolution of Sister Chromatid Cohesion

S33 mutants of beta-catenin aren't phosphorylated

S37 mutants of beta-catenin aren't phosphorylated

S45 mutants of beta-catenin aren't phosphorylated

Separation of Sister Chromatids

Spry regulation of FGF signaling

T41 mutants of beta-catenin aren't phosphorylated

truncations of AMER1 destabilize the destruction complex

By Organism (2)

Clustered By Gene (0)

By Shared ChEMBL Annotated Substances