UCSF

Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse (3 Compounds)

Swissprot:
PP2AA_MOUSE
Stitch:
PP2AA_MOUSE
UniProt:
P63330
ChEMBL:
CHEMBL2451
Reactome:
REACT_230286
REACT_252458
REACT_218396
REACT_261568
REACT_206803
REACT_258573
REACT_203795
REACT_203336
REACT_216784
REACT_215063
REACT_210064
REACT_232322
REACT_208887
REACT_210180
REACT_217323
REACT_196577
REACT_261276
REACT_256756
REACT_198528
REACT_245985
REACT_198961
REACT_260752
REACT_234076
REACT_248000
REACT_207679
REACT_198526
REACT_258576
REACT_250714
PDB:
Ppp2ca

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3 2 2 1
Binding ≤ 1μM 3 2 2 1

Reactome Network (28)

Reactome ID Description Species
REACT_230286 APC truncation mutants have impaired AXIN binding Mus musculus
REACT_252458 AXIN missense mutants destabilize the destruction complex Mus musculus
REACT_218396 Beta-catenin phosphorylation cascade Mus musculus
REACT_261568 CTLA4 inhibitory signaling Mus musculus
REACT_206803 Cyclin A/B1 associated events during G2/M transition Mus musculus
REACT_258573 Cyclin D associated events in G1 Mus musculus
REACT_203795 DARPP-32 events Mus musculus
REACT_203336 Degradation of beta-catenin by the destruction complex Mus musculus
REACT_216784 disassembly of the destruction complex and recruitment of AXIN to the membrane Mus musculus
REACT_215063 ERK/MAPK targets Mus musculus
REACT_210064 ERKs are inactivated Mus musculus
REACT_232322 Glycolysis Mus musculus
REACT_208887 Inhibition of replication initiation of damaged DNA by RB1/E2F1 Mus musculus
REACT_210180 Initiation of Nuclear Envelope Reformation Mus musculus
REACT_217323 Integration of energy metabolism Mus musculus
REACT_196577 MASTL Facilitates Mitotic Progression Mus musculus
REACT_261276 misspliced GSK3beta mutants stabilize beta-catenin Mus musculus
REACT_256756 Mitotic Prometaphase Mus musculus
REACT_198528 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Mus musculus
REACT_245985 PP2A-mediated dephosphorylation of key metabolic factors Mus musculus
REACT_198961 Resolution of Sister Chromatid Cohesion Mus musculus
REACT_260752 S33 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_234076 S37 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_248000 S45 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_207679 Separation of Sister Chromatids Mus musculus
REACT_198526 Spry regulation of FGF signaling Mus musculus
REACT_258576 T41 mutants of beta-catenin aren't phosphorylated Mus musculus
REACT_250714 truncations of AMER1 destabilize the destruction complex Mus musculus
Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

AXIN missense mutants destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Beta-catenin phosphorylation cascade

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

CTLA4 inhibitory signaling

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Cyclin A/B1 associated events during G2/M transition

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Cyclin D associated events in G1

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

DARPP-32 events

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Degradation of beta-catenin by the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

disassembly of the destruction complex and recruitment of AXIN to the membrane

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

ERK/MAPK targets

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

ERKs are inactivated

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Glycolysis

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Initiation of Nuclear Envelope Reformation

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Integration of energy metabolism

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

MASTL Facilitates Mitotic Progression

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

misspliced GSK3beta mutants stabilize beta-catenin

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Mitotic Prometaphase

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

PP2A-mediated dephosphorylation of key metabolic factors

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Resolution of Sister Chromatid Cohesion

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

S33 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

S37 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

S45 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Separation of Sister Chromatids

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

Spry regulation of FGF signaling

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

T41 mutants of beta-catenin aren't phosphorylated

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1

truncations of AMER1 destabilize the destruction complex

Uniprot Swissprot Chembl Description Number Shared
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PP2AA_BOVIN P67774 CHEMBL3862 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Bovin 5 0 0 0
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 23 9 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PP2AB_HUMAN P62714 CHEMBL2435 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human 3
PPM1J_MOUSE Q149T7 CHEMBL2776 Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse 3
2A5A_HUMAN Q15172 CHEMBL4763 Serine/threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform, Human 1
2AAA_MOUSE Q76MZ3 CHEMBL3557 Serine/threonine Protein Phosphatase 2A, 65 KDa Regulatory Subunit A, Alpha Isoform, Mouse 1
2ABG_HUMAN Q9Y2T4 CHEMBL2507 Serine/threonine Protein Phosphatase 2A, 55 KDa Regulatory Subunit B, Gamma Isoform, Human 1
PP1A_HUMAN P62136 CHEMBL2164 Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PP2AA_HUMAN P67775 CHEMBL4703 Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Human 1
PPM1B_HUMAN O75688 CHEMBL2845 Protein Phosphatase 2C Beta, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
PTPA_HUMAN Q15257 CHEMBL2505 Protein Phosphatase 2A Regulatory Subunit B', Human 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1