UCSF

Phospholipase A2 Group IIA, Human (315 Compounds)

Swissprot:
PA2GA_HUMAN
Stitch:
PA2GA_HUMAN
UniProt:
P14555
ChEMBL:
CHEMBL3474
Reactome:
REACT_120829
REACT_121369
REACT_121324
REACT_120722
REACT_121384
REACT_120906
PDB:
1AYP (DOCK)
1BBC (DOCK)
1DB4 (DOCK)
1DB5 (DOCK)
1DCY (DOCK)
1J1A (DOCK)
1KQU (DOCK)
1KVO (DOCK)
1N28 (DOCK)
1N29 (DOCK)
1POD (DOCK)
1POE (DOCK)
2GNY (DOCK)
PLA2G2A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 315 7 3 3
Binding ≤ 1μM 216 4 2 3
Functional ≤ 10μM 71 2 0 0
Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27

Acyl chain remodelling of PE

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27

Acyl chain remodelling of PG

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27

Acyl chain remodelling of PI

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27

Acyl chain remodelling of PS

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27

Synthesis of PA

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PA2GA_MOUSE P31482 CHEMBL5761 Phospholipase A2, Membrane Associated, Mouse 15 1 1 1
PA2GA_RABIT P14422 CHEMBL5481 Phospholipase A2, Membrane Associated, Rabit 5 0 0 0
PA2GA_RAT P14423 CHEMBL3686 Phospholipase A2 Group IIA, Rat 7 0 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
PA2GA-1-E Phospholipase A2, Membrane Associated (cluster #1 Of 3), Eukaryotic 279 5 2 3
PA2GA-2-E Phospholipase A2, Membrane Associated (cluster #2 Of 3), Eukaryotic 16 0 0 0
PA2GA-3-E Phospholipase A2, Membrane Associated (cluster #3 Of 3), Eukaryotic 26 2 1 0
Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 61
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 59
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 31
PA2GE_HUMAN Q9NZK7 CHEMBL2154 Group IIE Secretory Phospholipase A2, Human 27
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 22
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 21
PA21B_PIG P00592 CHEMBL4715 Phospholipase A2 Group 1B, Pig 18
PA2G5_MOUSE P97391 CHEMBL4167 Phospholipase A2 Group V, Mouse 17
PA2GA_MOUSE P31482 CHEMBL5761 Phospholipase A2, Membrane Associated, Mouse 15
PA21B_MOUSE Q9Z0Y2 CHEMBL4378 Phospholipase A2 Group 1B, Mouse 12
PA2GE_MOUSE Q9QUL3 CHEMBL4201 Group IIE Secretory Phospholipase A2, Mouse 12
PA2_APIME P00630 CHEMBL4807 Phospholipase A2 (Bee), Apime 12
PA2GX_MOUSE Q9QXX3 CHEMBL4200 Group X Secretory Phospholipase A2, Mouse 10
Q6UB75_PIG Q6UB75 CHEMBL3651 Group VII Phospholipase A2, Pig 8
PA2GA_RAT P14423 CHEMBL3686 Phospholipase A2 Group IIA, Rat 7
PAFA_HUMAN Q13093 CHEMBL3514 LDL-associated Phospholipase A2, Human 6
Q65ZF5_NAJNA Q65ZF5 CHEMBL5612 Phospholipase A2, Najna 6
PA2GA_RABIT P14422 CHEMBL5481 Phospholipase A2, Membrane Associated, Rabit 5
PA2GD_MOUSE Q9WVF6 CHEMBL5537 Group IID Secretory Phospholipase A2, Mouse 4
PA2GF_MOUSE Q9QZT4 CHEMBL5361 Group IIF Secretory Phospholipase A2, Mouse 3
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 2
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 1
DPOLB_RAT P06766 CHEMBL4343 DNA Polymerase Beta, Rat 1
LKHA4_HUMAN P09960 CHEMBL4618 Leukotriene A4 Hydrolase, Human 1
PA21B_NAJME P00599 CHEMBL3967 Phospholipase A2 Isozyme DE-I, Najme 1
PA2A_PROFL P59264 CHEMBL5022 Phospholipase A2 Isozyme PLA-A, Profl 1
PA2_CROAD P00623 CHEMBL5711 Phospholipase A2 Alpha, Croad 1
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 1
PYGM_RABIT P00489 CHEMBL4696 Glycogen Phosphorylase, Muscle Form, Rabit 1
Q7T3S7_ECHCA Q7T3S7 CHEMBL4195 Phospholipase A2, Echca 1