UCSF

Group IIE Secretory Phospholipase A2, Human (30 Compounds)

Swissprot:
PA2GE_HUMAN
Stitch:
PA2GE_HUMAN
UniProt:
Q9NZK7
ChEMBL:
CHEMBL2154
Reactome:
REACT_120829
REACT_121369
REACT_121324
REACT_120722
REACT_121384
REACT_120906
PDB:
PLA2G2E

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 30 2 2 1
Binding ≤ 1μM 29 2 2 1

Reactome Network (6)

Reactome ID Description Species
REACT_120829 Acyl chain remodelling of PC Homo sapiens
REACT_121369 Acyl chain remodelling of PE Homo sapiens
REACT_121324 Acyl chain remodelling of PG Homo sapiens
REACT_120722 Acyl chain remodelling of PI Homo sapiens
REACT_121384 Acyl chain remodelling of PS Homo sapiens
REACT_120906 Synthesis of PA Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13

Acyl chain remodelling of PE

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13

Acyl chain remodelling of PG

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13

Acyl chain remodelling of PI

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13

Acyl chain remodelling of PS

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13

Synthesis of PA

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PA2GE_MOUSE Q9QUL3 CHEMBL4201 Group IIE Secretory Phospholipase A2, Mouse 13 1 1 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PA2GE-1-E Group IIE Secretory Phospholipase A2 (cluster #1 Of 2), Eukaryotic 29 1 1 1
PA2GE-2-E Group IIE Secretory Phospholipase A2 (cluster #2 Of 2), Eukaryotic 1 1 1 0
Uniprot Swissprot Chembl Description Number Shared
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 27
PA2GD_HUMAN Q9UNK4 CHEMBL4281 Group IID Secretory Phospholipase A2, Human 25
PA2GF_HUMAN Q9BZM2 CHEMBL4278 Group IIF Secretory Phospholipase A2, Human 24
PA21B_MOUSE Q9Z0Y2 CHEMBL4378 Phospholipase A2 Group 1B, Mouse 15
PA2GE_MOUSE Q9QUL3 CHEMBL4201 Group IIE Secretory Phospholipase A2, Mouse 13
PA2GX_HUMAN O15496 CHEMBL4342 Group X Secretory Phospholipase A2, Human 13
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 11
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 10
PA2G5_MOUSE P97391 CHEMBL4167 Phospholipase A2 Group V, Mouse 10
PA2GX_MOUSE Q9QXX3 CHEMBL4200 Group X Secretory Phospholipase A2, Mouse 10
PA2GA_MOUSE P31482 CHEMBL5761 Phospholipase A2, Membrane Associated, Mouse 8
PA2GD_MOUSE Q9WVF6 CHEMBL5537 Group IID Secretory Phospholipase A2, Mouse 6
PA2GF_MOUSE Q9QZT4 CHEMBL5361 Group IIF Secretory Phospholipase A2, Mouse 5
PA21B_PIG P00592 CHEMBL4715 Phospholipase A2 Group 1B, Pig 2
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 1
DPOLB_RAT P06766 CHEMBL4343 DNA Polymerase Beta, Rat 1
PA21B_NAJME P00599 CHEMBL3967 Phospholipase A2 Isozyme DE-I, Najme 1
PA2A_PROFL P59264 CHEMBL5022 Phospholipase A2 Isozyme PLA-A, Profl 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
PTN2_HUMAN P17706 CHEMBL3807 T-cell Protein-tyrosine Phosphatase, Human 1
PYGM_RABIT P00489 CHEMBL4696 Glycogen Phosphorylase, Muscle Form, Rabit 1
Q7T3S7_ECHCA Q7T3S7 CHEMBL4195 Phospholipase A2, Echca 1