UCSF

Cytosolic Phospholipase A2, Human (227 Compounds)

Swissprot:
PA24A_HUMAN
Stitch:
PA24A_HUMAN
UniProt:
P47712
ChEMBL:
CHEMBL3816
Reactome:
REACT_121006
REACT_120829
REACT_121369
REACT_121324
REACT_120722
REACT_121384
REACT_19140
REACT_147851
REACT_120977
REACT_15466
REACT_23879
REACT_120906
PDB:
1BCI (DOCK)
1CJY (DOCK)
1RLW (DOCK)
PLA2G4A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 227 2 1 0
Binding ≤ 1μM 153 1 0 0
Functional ≤ 10μM 69 1 0 0

Reactome Network (12)

Reactome ID Description Species
REACT_121006 Acyl chain remodeling of CL Homo sapiens
REACT_120829 Acyl chain remodelling of PC Homo sapiens
REACT_121369 Acyl chain remodelling of PE Homo sapiens
REACT_121324 Acyl chain remodelling of PG Homo sapiens
REACT_120722 Acyl chain remodelling of PI Homo sapiens
REACT_121384 Acyl chain remodelling of PS Homo sapiens
REACT_19140 ADP signalling through P2Y purinoceptor 1 Homo sapiens
REACT_147851 Arachidonic acid metabolism Homo sapiens
REACT_120977 Hydrolysis of LPC Homo sapiens
REACT_15466 phospho-PLA2 pathway Homo sapiens
REACT_23879 Platelet sensitization by LDL Homo sapiens
REACT_120906 Synthesis of PA Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PA2G6_HUMAN O60733 CHEMBL3213 Calcium-independent Phospholipase A2, Human 22

Acyl chain remodelling of PC

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 24
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2G6_HUMAN O60733 CHEMBL3213 Calcium-independent Phospholipase A2, Human 22
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Acyl chain remodelling of PE

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 24
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2G6_HUMAN O60733 CHEMBL3213 Calcium-independent Phospholipase A2, Human 22
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Acyl chain remodelling of PG

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Acyl chain remodelling of PI

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 24
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Acyl chain remodelling of PS

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Hydrolysis of LPC

Uniprot Swissprot Chembl Description Number Shared
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 24
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22

Synthesis of PA

Uniprot Swissprot Chembl Description Number Shared
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
PA24A-1-E Cytosolic Phospholipase A2 (cluster #1 Of 3), Eukaryotic 4 1 1 0
PA24A-2-E Cytosolic Phospholipase A2 (cluster #2 Of 3), Eukaryotic 222 1 0 0
PA24A-3-E Cytosolic Phospholipase A2 (cluster #3 Of 3), Eukaryotic 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
PA2GA_HUMAN P14555 CHEMBL3474 Phospholipase A2 Group IIA, Human 31
PA21B_HUMAN P04054 CHEMBL4426 Phospholipase A2 Group 1B, Human 30
PA2G5_HUMAN P39877 CHEMBL4323 Phospholipase A2 Group V, Human 30
PA24C_HUMAN Q9UP65 CHEMBL4834 Cytosolic Phospholipase A2 Gamma, Human 24
PA24B_HUMAN P0C869 CHEMBL4136 Phospholipase A2 Group 1VB, Human 23
PA24D_HUMAN Q86XP0 CHEMBL2287 Phospholipase A2 Group 1VD, Human 22
PA2G6_HUMAN O60733 CHEMBL3213 Calcium-independent Phospholipase A2, Human 22
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 20
FAAH1_RAT P97612 CHEMBL3229 Anandamide Amidohydrolase, Rat 16
PAFA_HUMAN Q13093 CHEMBL3514 LDL-associated Phospholipase A2, Human 6
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 5
FAAH1_HUMAN O00519 CHEMBL2243 Anandamide Amidohydrolase, Human 3
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 3
MGLL_HUMAN Q99685 CHEMBL4191 Monoglyceride Lipase, Human 3
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 3
Z50587 Z50587 CHEMBL372 Homo Sapiens 3
CNR1_MOUSE P47746 CHEMBL3037 Cannabinoid CB1 Receptor, Mouse 2
CNR1_RAT P20272 CHEMBL3571 Cannabinoid CB1 Receptor, Rat 2
FAAH1_MOUSE O08914 CHEMBL3455 Anandamide Amidohydrolase, Mouse 2
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 2
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 2
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 2
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 1

Most Common Rings