UCSF

Dual Specificity Phosphatase Cdc25C, Human (24 Compounds)

Swissprot:
MPIP3_HUMAN
Stitch:
MPIP3_HUMAN
UniProt:
P30307
ChEMBL:
CHEMBL2378
Reactome:
REACT_6769
REACT_407
REACT_1857
REACT_2101
REACT_1006
PDB:
3BZI (DOCK)
3OP3 (DOCK)
CDC25C

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 24 2 0 0
Binding ≤ 1μM 10 2 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_6769 Activation of ATR in response to replication stress Homo sapiens
REACT_407 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Homo sapiens
REACT_1857 Cyclin A/B1 associated events during G2/M transition Homo sapiens
REACT_2101 Cyclin B2 mediated events Homo sapiens
REACT_1006 Polo-like kinase mediated events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 15

Cyclin A/B1 associated events during G2/M transition

Uniprot Swissprot Chembl Description Number Shared
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 15
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 13

Cyclin B2 mediated events

Uniprot Swissprot Chembl Description Number Shared
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 15
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 13

Polo-like kinase mediated events

Uniprot Swissprot Chembl Description Number Shared
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 15
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 164 27 4 1
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 240 48 6 2

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MPIP3-1-E Dual Specificity Phosphatase Cdc25C (cluster #1 Of 2), Eukaryotic 5 0 0 0
MPIP3-2-E Dual Specificity Phosphatase Cdc25C (cluster #2 Of 2), Eukaryotic 19 2 0 0
Uniprot Swissprot Chembl Description Number Shared
MPIP1_HUMAN P30304 CHEMBL3775 Dual Specificity Phosphatase Cdc25A, Human 15
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 13
DUS3_HUMAN P51452 CHEMBL2635 Dual Specificity Protein Phosphatase 3, Human 1
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 1
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 1
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 1
PTPRF_HUMAN P10586 CHEMBL3521 Receptor-type Tyrosine-protein Phosphatase F (LAR), Human 1
YOPH_YEREN P15273 CHEMBL4404 Tyrosine-protein Phosphatase YopH, Yeren 1

Most Common Rings