UCSF

C-C Chemokine Receptor Type 5, Human (1,843 Compounds)

Swissprot:
CCR5_HUMAN
Stitch:
CCR5_HUMAN
UniProt:
P51681
ChEMBL:
CHEMBL274
Reactome:
REACT_6903
REACT_15344
REACT_19231
PDB:
1ND8 (DOCK)
1NE0 (DOCK)
1OPN (DOCK)
1OPT (DOCK)
1OPW (DOCK)
2L87 (DOCK)
2RLL (DOCK)
CCR5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,843 7 2 4
Binding ≤ 1μM 1,666 2 2 4
Functional ≤ 10μM 284 6 2 3

Reactome Network (3)

Reactome ID Description Species
REACT_6903 Binding and entry of HIV virion Homo sapiens
REACT_15344 Chemokine receptors bind chemokines Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 3

Chemokine receptors bind chemokines

Uniprot Swissprot Chembl Description Number Shared
CCL5_HUMAN P13501 CHEMBL1275217 C-C Motif Chemokine 5, Human 32
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 14
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 38
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 5
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 16
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 3
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 3

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 30
CCL5_HUMAN P13501 CHEMBL1275217 C-C Motif Chemokine 5, Human 32
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 14
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 38
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 5
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 16
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 2
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 3
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CCR5_MACFA P61814 CHEMBL1075263 C-C Chemokine Receptor Type 5, Macfa 18 0 0 0
CCR5_MOUSE P51682 CHEMBL3676 C-C Chemokine Receptor Type 5, Mouse 53 1 1 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 383 10 0 0
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 1,214 6 1 2
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 908 15 2 1
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 238 6 1 1
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1 0 0 0
CCR8_HUMAN P51685 CHEMBL4596 C-C Chemokine Receptor Type 8, Human 68 3 0 0
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1 0 0 0

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
CCR5-1-E C-C Chemokine Receptor Type 5 (cluster #1 Of 4), Eukaryotic 1,786 5 3 4
CCR5-2-E C-C Chemokine Receptor Type 5 (cluster #2 Of 4), Eukaryotic 91 3 0 1
CCR5-3-E C-C Chemokine Receptor Type 5 (cluster #3 Of 4), Eukaryotic 1 0 0 0
CCR5-4-E C-C Chemokine Receptor Type 5 (cluster #4 Of 4), Eukaryotic 2 0 0 0
Uniprot Swissprot Chembl Description Number Shared
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 53
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 51
CCR2_HUMAN P41597 CHEMBL4015 C-C Chemokine Receptor Type 2, Human 36
CCL5_HUMAN P13501 CHEMBL1275217 C-C Motif Chemokine 5, Human 32
Z80107 Z80107 CHEMBL614564 COS-7 (Kidney Cells) 31
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 31
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 30
CCR5_MOUSE P51682 CHEMBL3676 C-C Chemokine Receptor Type 5, Mouse 29
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 22
CCR5_MACFA P61814 CHEMBL1075263 C-C Chemokine Receptor Type 5, Macfa 18
CCR4_HUMAN P51679 CHEMBL2414 C-C Chemokine Receptor Type 4, Human 16
CCR1_HUMAN P32246 CHEMBL2413 C-C Chemokine Receptor Type 1, Human 14
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 6
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 5
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 4
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 4
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 3
CCR2_MOUSE P51683 CHEMBL5412 C-C Chemokine Receptor Type 2, Mouse 3
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 3
CXCR4_HUMAN P61073 CHEMBL2107 C-X-C Chemokine Receptor Type 4, Human 3
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 3
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 3
SCN1A_RAT P04774 CHEMBL4906 Sodium Channel Protein Type I Alpha Subunit, Rat 3
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 3
SCN3A_RAT P08104 CHEMBL4966 Sodium Channel Protein Type III Alpha Subunit, Rat 3
SCN4A_RAT P15390 CHEMBL3509 Sodium Channel Protein Type IV Alpha Subunit, Rat 3
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 3
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 3
SCN9A_RAT O08562 CHEMBL3312 Sodium Channel Protein Type IX Alpha Subunit, Rat 3
SCNAA_RAT Q62968 CHEMBL4017 Sodium Channel Protein Type X Alpha Subunit, Rat 3
SCNBA_RAT O88457 CHEMBL2629 Sodium Channel Protein Type XI Alpha Subunit, Rat 3
Z50677 Z50677 CHEMBL613758 Human Immunodeficiency Virus 3
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 2
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 2
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 2
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 2
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 2
CCR2_RAT O55193 CHEMBL1293204 C-C Chemokine Receptor Type 2, Rat 2
CCR3_MOUSE P51678 CHEMBL3406 C-C Chemokine Receptor Type 3, Mouse 2
CCR3_RAT O54814 CHEMBL3928 C-C Chemokine Receptor Type 3, Rat 2
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 2
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 2
NK3R_HUMAN P29371 CHEMBL4429 Neurokinin 3 Receptor, Human 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 2
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 2
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 1
CCR1_MOUSE P51675 CHEMBL3872 C-C Chemokine Receptor Type 1, Mouse 1
CCR7_HUMAN P32248 CHEMBL4594 C-C Chemokine Receptor Type 7, Human 1
CCR9_HUMAN P51686 CHEMBL5815 C-C Chemokine Receptor Type 9, Human 1
CXCR4_RAT O08565 CHEMBL5556 C-X-C Chemokine Receptor Type 4, Rat 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 1
Z80565 Z80565 CHEMBL614247 U-87 MG (Glioblastoma Cells) 1

Most Common Rings