UCSF

NF-kappa-B Essential Modulator, Human (15 Compounds)

Swissprot:
NEMO_HUMAN
Stitch:
NEMO_HUMAN
UniProt:
Q9Y6K9
ChEMBL:
CHEMBL4967
Reactome:
REACT_21399
REACT_118656
REACT_12555
REACT_163994
REACT_25374
REACT_22442
REACT_24918
REACT_25354
REACT_21368
REACT_25039
REACT_75776
REACT_118563
REACT_21281
REACT_24969
PDB:
2JVX (DOCK)
2JVY (DOCK)
3BRT (DOCK)
3BRV (DOCK)
3CL3 (DOCK)
3FX0 (DOCK)
IKBKG

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 15 1 0 0
Binding ≤ 1μM 13 1 0 0
Functional ≤ 10μM 8 2 0 0

Reactome Network (14)

Reactome ID Description Species
REACT_21399 activated TAK1 mediates p38 MAPK activation Homo sapiens
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_163994 FCERI mediated NF-kB activation Homo sapiens
REACT_25374 IKK complex recruitment mediated by RIP1 Homo sapiens
REACT_22442 Interleukin-1 signaling Homo sapiens
REACT_24918 IRAK1 recruits IKK complex Homo sapiens
REACT_25354 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Homo sapiens
REACT_21368 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human Homo sapiens
REACT_25039 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Homo sapiens
REACT_75776 NOD1/2 Signaling Pathway Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

FCERI mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

IKK complex recruitment mediated by RIP1

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

Interleukin-1 signaling

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

IRAK1 recruits IKK complex

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

NOD1/2 Signaling Pathway

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 16
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 16
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 7
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 7
IKKE_HUMAN Q14164 CHEMBL3529 Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit, Human 1
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1