UCSF

Bile Acid Receptor FXR, Human (372 Compounds)

Swissprot:
NR1H4_HUMAN
Stitch:
NR1H4_HUMAN
UniProt:
Q96RI1
ChEMBL:
CHEMBL2047
Reactome:
REACT_13812
REACT_116145
REACT_11042
REACT_11054
REACT_11048
REACT_11041
PDB:
1OSH (DOCK)
1OSK (DOCK)
3BEJ (DOCK)
3DCT (DOCK)
3DCU (DOCK)
3FLI (DOCK)
3FXV (DOCK)
3GD2 (DOCK)
3HC5 (DOCK)
3HC6 (DOCK)
3L1B (DOCK)
3OKH (DOCK)
3OKI (DOCK)
3OLF (DOCK)
3OMK (DOCK)
3OMM (DOCK)
3OOF (DOCK)
3OOK (DOCK)
3P88 (DOCK)
3P89 (DOCK)
3RUT (DOCK)
3RUU (DOCK)
3RVF (DOCK)
NR1H4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 372 7 7 3
Binding ≤ 1μM 265 4 4 2
Functional ≤ 10μM 330 21 20 3

Reactome Network (6)

Reactome ID Description Species
REACT_13812 Endogenous sterols Homo sapiens
REACT_116145 PPARA activates gene expression Homo sapiens
REACT_11042 Recycling of bile acids and salts Homo sapiens
REACT_11054 Synthesis of bile acids and bile salts Homo sapiens
REACT_11048 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Homo sapiens
REACT_11041 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1

PPARA activates gene expression

Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1

Recycling of bile acids and salts

Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1

Synthesis of bile acids and bile salts

Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

Uniprot Swissprot Chembl Description Number Shared
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NR1H2_HUMAN P55055 CHEMBL4093 LXR-beta, Human 442 4 4 2
NR1H3_HUMAN Q13133 CHEMBL2808 LXR-alpha, Human 485 14 11 3

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NR1H4-1-E Bile Acid Receptor FXR (cluster #1 Of 2), Eukaryotic 302 4 3 1
NR1H4-2-E Bile Acid Receptor FXR (cluster #2 Of 2), Eukaryotic 71 3 5 3
Uniprot Swissprot Chembl Description Number Shared
GPBAR_HUMAN Q8TDU6 CHEMBL5409 G-protein Coupled Bile Acid Receptor 1, Human 23
NR1H4_MOUSE Q60641 CHEMBL5343 Bile Acid Receptor, Mouse 14
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 6
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 4
Z50420 Z50420 CHEMBL612851 Trypanosoma Brucei Brucei 3
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50602 Z50602 CHEMBL377 Human Herpesvirus 1 2
Z50652 Z50652 CHEMBL613740 Influenza A Virus 2
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 2
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 2
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 2
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 2
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 1
MCR_HUMAN P08235 CHEMBL1994 Mineralocorticoid Receptor, Human 1
PRGR_HUMAN P06401 CHEMBL208 Progesterone Receptor, Human 1
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 1
RXRB_HUMAN P28702 CHEMBL1870 Retinoid X Receptor Beta, Human 1
RXRG_HUMAN P48443 CHEMBL2004 Retinoid X Receptor Gamma, Human 1
Z100499 Z100499 CHEMBL612575 SARS Coronavirus 1
Z103202 Z103202 CHEMBL1075387 8505C 1
Z103205 Z103205 CHEMBL1075390 A431 1
Z50418 Z50418 CHEMBL612849 Trypanosoma Brucei 1
Z50426 Z50426 CHEMBL612856 Plasmodium Falciparum (isolate K1 / Thailand) 1
Z50459 Z50459 CHEMBL367 Leishmania Donovani 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50472 Z50472 CHEMBL612888 Toxoplasma Gondii 1
Z50636 Z50636 CHEMBL613725 Sindbis Virus 1
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80482 Z80482 CHEMBL614917 SK-MEL-2 (Melanoma Cells) 1
Z80526 Z80526 CHEMBL612544 SW480 (Colon Adenocarcinoma Cells) 1
Z80897 Z80897 CHEMBL614806 H9 (T-lymphoid Cells) 1
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 1
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 1
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 1

Most Common Rings