| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Functional ≤ 10μM | 14 | 2 | 2 | 1 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_227038 | Endogenous sterols | Mus musculus |
| REACT_234105 | Nuclear Receptor transcription pathway | Mus musculus |
| REACT_198602 | PPARA activates gene expression | Mus musculus |
| REACT_239346 | Recycling of bile acids and salts | Mus musculus |
| REACT_207530 | Synthesis of bile acids and bile salts | Mus musculus |
| REACT_226440 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | Mus musculus |
| REACT_203193 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Mus musculus |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| NR1H4-1-E | Bile Acid Receptor FXR (cluster #1 Of 2), Eukaryotic | 302 | 4 | 3 | 1 |
| NR1H4-2-E | Bile Acid Receptor FXR (cluster #2 Of 2), Eukaryotic | 71 | 3 | 5 | 3 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| NR1H4_HUMAN | Q96RI1 | CHEMBL2047 | Bile Acid Receptor FXR, Human | 14 |
| ANDR_HUMAN | P10275 | CHEMBL1871 | Androgen Receptor, Human | 1 |
| ESR1_HUMAN | P03372 | CHEMBL206 | Estrogen Receptor Alpha, Human | 1 |
| GCR_HUMAN | P04150 | CHEMBL2034 | Glucocorticoid Receptor, Human | 1 |
| MCR_HUMAN | P08235 | CHEMBL1994 | Mineralocorticoid Receptor, Human | 1 |
| PRGR_HUMAN | P06401 | CHEMBL208 | Progesterone Receptor, Human | 1 |