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ZINC 12

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Names
Compounds (1,263)
Reactome (1)
Related By:
Pathway (0)
Organism (3)
Gene (3)
Org. Clust. (2)
ChEMBL (10)
Rings (26)

Poly [ADP-ribose] Polymerase-1, Human (1,263 Compounds)

Swissprot:: PARP1_HUMAN
Stitch:: PARP1_HUMAN
UniProt:: P09874
ChEMBL:: CHEMBL3105
Reactome:: REACT_121111
PDB:: 1UK0 (DOCK); 1UK1 (DOCK); 1WOK (DOCK); 2COK (DOCK); 2CR9 (DOCK); 2CS2 (DOCK); 2DMJ (DOCK); 2JVN (DOCK); 2L30 (DOCK); 2L31 (DOCK); 2RCW (DOCK); 2RD6 (DOCK); 2RIQ (DOCK); 3GJW (DOCK); 3GN7 (DOCK); 3L3L (DOCK); 3L3M (DOCK); 3OD8 (DOCK); 3ODA (DOCK); 3ODC (DOCK); 3ODE (DOCK); PARP1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,263	60	8	13
Binding ≤ 1μM	1,192	39	3	11

Reactome ID	Description	Species
REACT_121111	Downregulation of SMAD2/3:SMAD4 transcriptional activity	Homo sapiens

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PARP1_BOVIN	P18493	CHEMBL5691	Poly [ADP-ribose] Polymerase 1, Bovin	1	1	0	0
PARP1_MOUSE	P11103	CHEMBL3740	Poly [ADP-ribose] Polymerase-1, Mouse	54	6	1	2
PARP1_RAT	P27008	CHEMBL4664	Poly [ADP-ribose] Polymerase 1, Rat	32	0	0	0

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PARP2_HUMAN	Q9UGN5	CHEMBL5366	Poly [ADP-ribose] Polymerase 2, Human	47	7	2	2
PARP3_HUMAN	Q9Y6F1	CHEMBL5083	Poly [ADP-ribose] Polymerase 3, Human	8	3	0	3
PARP4_HUMAN	Q9UKK3	CHEMBL6142	Poly [ADP-ribose] Polymerase 4, Human	5	1	0	0

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
PARP1-1-E	Poly [ADP-ribose] Polymerase 1 (cluster #1 Of 3), Eukaryotic	692	9	1	4
PARP1-2-E	Poly [ADP-ribose] Polymerase 1 (cluster #2 Of 3), Eukaryotic	477	42	5	6
PARP1-3-E	Poly [ADP-ribose] Polymerase 1 (cluster #3 Of 3), Eukaryotic	188	16	3	4

Uniprot	Swissprot	Chembl	Description	Number Shared
PARP2_HUMAN	Q9UGN5	CHEMBL5366	Poly [ADP-ribose] Polymerase 2, Human	47
PARP2_MOUSE	O88554	CHEMBL2794	Poly [ADP-ribose] Polymerase-2, Mouse	13
PARP3_HUMAN	Q9Y6F1	CHEMBL5083	Poly [ADP-ribose] Polymerase 3, Human	8
TNKS1_HUMAN	O95271	CHEMBL6164	Tankyrase-1, Human	7
PARP4_HUMAN	Q9UKK3	CHEMBL6142	Poly [ADP-ribose] Polymerase 4, Human	5
PARP1_MOUSE	P11103	CHEMBL3740	Poly [ADP-ribose] Polymerase-1, Mouse	4
Q8CFB8_MOUSE	Q8CFB8	CHEMBL3292	ADP-ribosyltransferase, Mouse	2
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
PARP1_BOVIN	P18493	CHEMBL5691	Poly [ADP-ribose] Polymerase 1, Bovin	1
TNKS2_HUMAN	Q9H2K2	CHEMBL6154	Tankyrase-2, Human	1

Synonyms
Compounds (1,263)
Related By:
Pathway (0)
Organism (3)
Gene (3)
ChEMBL (10)
Org. Clust. (2)
Rings (26)