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TNKS1_HUMAN - Tankyrase-1, Human | ZINC Is Not Commercial - A database of commercially-available compounds
UCSF

Tankyrase-1, Human (7 Compounds)

Swissprot:
TNKS1_HUMAN
Stitch:
TNKS1_HUMAN
UniProt:
O95271
ChEMBL:
CHEMBL6164
Reactome:
REACT_200766
REACT_200777
REACT_228279
PDB:
2RF5 (DOCK)
3UDD (DOCK)
TNKS

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 7 3 1 0
Binding ≤ 1μM 2 2 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_200766 degradation of AXIN Homo sapiens
REACT_200777 TCF dependent signaling in response to WNT Homo sapiens
REACT_228279 XAV939 inhibits tankyrase, stabilizing AXIN Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TNKS2_HUMAN Q9H2K2 CHEMBL6154 Tankyrase-2, Human 1

TCF dependent signaling in response to WNT

Uniprot Swissprot Chembl Description Number Shared
TNKS2_HUMAN Q9H2K2 CHEMBL6154 Tankyrase-2, Human 1

XAV939 inhibits tankyrase, stabilizing AXIN

Uniprot Swissprot Chembl Description Number Shared
TNKS2_HUMAN Q9H2K2 CHEMBL6154 Tankyrase-2, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TNKS2_HUMAN Q9H2K2 CHEMBL6154 Tankyrase-2, Human 2 2 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PARP1_HUMAN P09874 CHEMBL3105 Poly [ADP-ribose] Polymerase-1, Human 7
PARP2_HUMAN Q9UGN5 CHEMBL5366 Poly [ADP-ribose] Polymerase 2, Human 6
PARP3_HUMAN Q9Y6F1 CHEMBL5083 Poly [ADP-ribose] Polymerase 3, Human 5
PARP4_HUMAN Q9UKK3 CHEMBL6142 Poly [ADP-ribose] Polymerase 4, Human 5
TNKS2_HUMAN Q9H2K2 CHEMBL6154 Tankyrase-2, Human 1