UCSF
Image of Quinazoline

Identity 99% 90% 80% 70% Substructure

Quinazoline

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Ring Information

Rings Ring Systems Atoms Carbons Nitrogens Oxygens Sulfurs
2 1 10 8 2 0 0

Subset Information

Substances Natural Purchasable Annotated BB In Man Last Updated
View 5 9,035 155 101 0 2012-03-07

Most Common Targets

Name (Uniprot) Swissprot ChEMBL Description Size Browse Download (Annotations)
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 37 Annotations Catalogs SMILES SDF Mol2 Flexibase
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 37 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 22 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 21 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 18 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 16 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 15 Annotations Catalogs SMILES SDF Mol2 Flexibase
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 14 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 13 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 12 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 11 Annotations Catalogs SMILES SDF Mol2 Flexibase
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 10 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERBB4_HUMAN Q15303 CHEMBL3009 Receptor Protein-tyrosine Kinase ErbB-4, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
ERBB4_HUMAN Q15303 CHEMBL3009 Receptor Protein-tyrosine Kinase ErbB-4, Human 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 8 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z100492 Z100492 CHEMBL613878 MCF10 (Normal Breast Epithelial Cells) 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 6 Annotations Catalogs SMILES SDF Mol2 Flexibase
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
AURKA_HUMAN O14965 CHEMBL4722 Serine/threonine-protein Kinase Aurora-A, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
CLK3_HUMAN P49761 CHEMBL4226 Dual Specificity Protein Kinase CLK3, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
INCE_HUMAN Q9NQS7 CHEMBL5177 Inner Centromere Protein, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
INCE_HUMAN Q9NQS7 CHEMBL5177 Inner Centromere Protein, Human 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 5 Annotations Catalogs SMILES SDF Mol2 Flexibase
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX1R_HUMAN O43613 CHEMBL5113 Orexin Receptor 1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX1R_HUMAN O43613 CHEMBL5113 Orexin Receptor 1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX1R_HUMAN O43613 CHEMBL5113 Orexin Receptor 1, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX2R_HUMAN O43614 CHEMBL4792 Orexin Receptor 2, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX2R_HUMAN O43614 CHEMBL4792 Orexin Receptor 2, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 4 Annotations Catalogs SMILES SDF Mol2 Flexibase
EHMT2_HUMAN Q96KQ7 CHEMBL6032 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
EHMT2_HUMAN Q96KQ7 CHEMBL6032 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
OX2R_HUMAN O43614 CHEMBL4792 Orexin Receptor 2, Human 3 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z100091 Z100091 CHEMBL614666 HS27 (Fibroblast Cells) 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 2 Annotations Catalogs SMILES SDF Mol2 Flexibase
AKTS1_HUMAN Q96B36 CHEMBL1255161 Proline-rich AKT1 Substrate 1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
B2CL1_HUMAN Q07817 CHEMBL4625 Apoptosis Regulator Bcl-X, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EHMT1_HUMAN Q9H9B1 CHEMBL6031 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 5, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
EHMT1_HUMAN Q9H9B1 CHEMBL6031 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 5, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
PKD1_HUMAN P98161 CHEMBL5772 Polycystin-1, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SOAT1_RAT O70536 CHEMBL285 Acyl Coenzyme A:cholesterol Acyltransferase 1, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SOAT2_RAT Q7TQM4 CHEMBL2856 Acyl Coenzyme A:cholesterol Acyltransferase 2, Rat 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
TRPV1_HUMAN Q8NER1 CHEMBL4794 Vanilloid Receptor, Human 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104293 Z104293 CHEMBL1907599 Integrin Alpha-4/beta-1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z104293 Z104293 CHEMBL1907599 Integrin Alpha-4/beta-1 1 Annotations Catalogs SMILES SDF Mol2 Flexibase
Z50424 Z50424 CHEMBL612855 Cryptosporidium Parvum 1 Annotations Catalogs SMILES SDF Mol2 Flexibase