ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (895)
Reactome (4)
Related By:
Pathway (2)
Organism (12)
Gene (4)
Org. Clust. (7)
ChEMBL (46)
Rings (25)

Dihydrofolate Reductase, Human (895 Compounds)

Swissprot:: DYR_HUMAN
Stitch:: DYR_HUMAN
UniProt:: P00374
ChEMBL:: CHEMBL202
Reactome:: REACT_471; REACT_683; REACT_11167; REACT_111176
PDB:: 1BOZ (DOCK); 1DHF (DOCK); 1DLR (DOCK); 1DLS (DOCK); 1DRF (DOCK); 1HFP (DOCK); 1HFQ (DOCK); 1HFR (DOCK); 1KMS (DOCK); 1KMV (DOCK); 1MVS (DOCK); 1MVT (DOCK); 1OHJ (DOCK); 1OHK (DOCK); 1PD8 (DOCK); 1PD9 (DOCK); 1PDB (DOCK); 1S3U (DOCK); 1S3V (DOCK); 1S3W (DOCK); 1U71 (DOCK); 1U72 (DOCK); 1YHO (DOCK); 2C2S (DOCK); 2C2T (DOCK); 2DHF (DOCK); 2W3A (DOCK); 2W3B (DOCK); 2W3M (DOCK); 3EIG (DOCK); 3F8Y (DOCK); 3F8Z (DOCK); 3F91 (DOCK); 3FS6 (DOCK); 3GHC (DOCK); 3GHV (DOCK); 3GHW (DOCK); 3GI2 (DOCK); 3GYF (DOCK); 3L3R (DOCK); 3N0H (DOCK); 3NTZ (DOCK); 3NU0 (DOCK); 3NXO (DOCK); 3NXR (DOCK); 3NXT (DOCK); 3NXV (DOCK); 3NXX (DOCK); 3NXY (DOCK); 3NZD (DOCK); 3OAF (DOCK); 3S3V (DOCK); 3S7A (DOCK); DHFR

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	895	73	24	46
Binding ≤ 1μM	675	64	22	38
Functional ≤ 10μM	1	0	0	0

Reactome ID	Description	Species
REACT_471	E2F mediated regulation of DNA replication	Homo sapiens
REACT_683	G1/S-Specific Transcription	Homo sapiens
REACT_11167	Metabolism of folate and pterines	Homo sapiens
REACT_111176	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	55

G1/S-Specific Transcription

Uniprot	Swissprot	Chembl	Description	Number Shared
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	55

Metabolism of folate and pterines

Uniprot	Swissprot	Chembl	Description	Number Shared
S19A1_HUMAN	P41440	CHEMBL4833	Folate Transporter 1, Human	5

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DYR_BOVIN	P00376	CHEMBL1075051	Dihydrofolate Reductase, Bovin	50	2	2	2
DYR_CANAX	P22906	CHEMBL2329	Dihydrofolate Reductase, Canax	86	4	1	13
DYR_CHICK	P00378	CHEMBL2575	Dihydrofolate Reductase, Chick	14	6	4	4
DYR_ECOLI	P0ABQ4	CHEMBL1809	Dihydrofolate Reductase, Ecoli	117	8	6	11
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	97	10	6	13
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	277	46	11	13
DYR_MYCTU	P0A546	CHEMBL6065	Dihydrofolate Reductase, Myctu	1	1	1	1
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	355	18	7	16
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	585	34	8	19
DYR_STAAU	P0A017	CHEMBL1681620	Dihydrofolate Reductase, Staau	33	3	3	4
DYR_STAAW	Q8NWQ9	CHEMBL3644	Dihydrofolate Reductase, Staaw	12	0	0	0
DYR_YEAST	P07807	CHEMBL2576	Dihydrofolate Reductase, Yeast	48	3	1	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DYR1A_HUMAN	Q13627	CHEMBL2292	Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human	65	11	2	7
DYR1B_HUMAN	Q9Y463	CHEMBL5543	Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human	47	10	4	8
DYRK2_HUMAN	Q92630	CHEMBL4376	Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2, Human	43	3	2	2
DYRK3_HUMAN	O43781	CHEMBL4575	Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human	3	1	1	1

Clustered By Gene (0)

Clustered By Organism (7)

Code	Description	Substances	Purchasable	Natural	In Man
DYR-1-B	Dihydrofolate Reductase (cluster #1 Of 4), Bacterial	237	18	13	24
DYR-1-E	Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic	1,093	102	24	44
DYR-1-F	Dihydrofolate Reductase (cluster #1 Of 1), Fungal	450	21	7	28
DYR-2-B	Dihydrofolate Reductase (cluster #2 Of 4), Bacterial	2	0	0	0
DYR-2-E	Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic	165	9	2	3
DYR-3-B	Dihydrofolate Reductase (cluster #3 Of 4), Bacterial	1	1	1	1
DYR-3-E	Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic	219	3	3	9
DYR-4-B	Dihydrofolate Reductase (cluster #4 Of 4), Bacterial	7	0	0	1

Uniprot	Swissprot	Chembl	Description	Number Shared
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	266
DRTS_TOXGO	Q07422	CHEMBL2425	Dihydrofolate Reductase, Toxgo	209
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	130
DYR_CANAX	P22906	CHEMBL2329	Dihydrofolate Reductase, Canax	82
DYR_ECOLI	P0ABQ4	CHEMBL1809	Dihydrofolate Reductase, Ecoli	74
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	57
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	55
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	44
DYR_STAAU	P0A017	CHEMBL1681620	Dihydrofolate Reductase, Staau	29
DYR_BOVIN	P00376	CHEMBL1075051	Dihydrofolate Reductase, Bovin	23
Q81R22_BACAN	Q81R22	CHEMBL5270	Dihydrofolate Reductase, Bacan	23
O30463_MYCAV	O30463	CHEMBL5457	Dihydrofolate Reductase, Mycav	22
TYSY_ECOLI	P0A884	CHEMBL2555	Thymidylate Synthase, Ecoli	20
C3SWJ7_ECOLX	C3SWJ7	CHEMBL6137	Thymidylate Synthase, Ecolx	13
DYR1_ECOLX	P00382	CHEMBL2627	Dihydrofolate Reductase Type 1, Ecolx	13
DYR_STAAW	Q8NWQ9	CHEMBL3644	Dihydrofolate Reductase, Staaw	12
DYR_YEAST	P07807	CHEMBL2576	Dihydrofolate Reductase, Yeast	9
DRTS_TRYCR	Q27793	CHEMBL1163130	Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr	7
FOLC_MOUSE	P48760	CHEMBL2890	Folylpoly-gamma-glutamate Synthetase, Mouse	7
TYSY_LACCA	P00469	CHEMBL5328	Thymidylate Synthase, Lacca	7
DRTS_PLAFK	P13922	CHEMBL1939	Dihydrofolate Reductase, Plafk	6
DYR_CHICK	P00378	CHEMBL2575	Dihydrofolate Reductase, Chick	6
PUR2_MOUSE	Q64737	CHEMBL3690	GAR Transformylase, Mouse	6
B0BL08_ECOLX	B0BL08	CHEMBL5441	Dihydrofolate Reductase, Ecolx	5
S19A1_HUMAN	P41440	CHEMBL4833	Folate Transporter 1, Human	5
E2QDN0_ECOLX	E2QDN0	CHEMBL1795153	Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx	4
GHSR_HUMAN	Q92847	CHEMBL4616	Ghrelin Receptor, Human	4
TYSY_CRYNB	P0CS13	CHEMBL4665	Thymidylate Synthase, Crynb	4
FOLC_HUMAN	Q05932	CHEMBL3171	Folylpoly-gamma-glutamate Synthetase, Human	3
TYSY_MOUSE	P07607	CHEMBL3160	Thymidylate Synthase, Mouse	3
TYSY_RAT	P45352	CHEMBL4341	Thymidylate Synthase, Rat	3
VGFR2_HUMAN	P35968	CHEMBL279	Vascular Endothelial Growth Factor Receptor 2, Human	3
AMPC_ECOLI	P00811	CHEMBL2026	Beta-lactamase, Ecoli	2
EGFR_HUMAN	P00533	CHEMBL203	Epidermal Growth Factor Receptor ErbB1, Human	2
PTR1_LEIMA	Q01782	CHEMBL6194	Pteridine Reductase 1, Leima	2
CLAT_HUMAN	P28329	CHEMBL4039	Choline Acetylase, Human	1
CTRC_HUMAN	Q99895	CHEMBL2386	Chymotrypsin C, Human	1
EDNRA_RAT	P26684	CHEMBL4566	Endothelin Receptor ET-A, Rat	1
ENPP2_HUMAN	Q13822	CHEMBL3691	Autotaxin, Human	1
FOLR1_HUMAN	P15328	CHEMBL2121	Folate Receptor Alpha, Human	1
FOLR2_HUMAN	P14207	CHEMBL5064	Folate Receptor Beta, Human	1
FOLR3_HUMAN	P41439	CHEMBL3885	Folate Receptor Gamma, Human	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
PUR2_HUMAN	P22102	CHEMBL3972	GAR Transformylase, Human	1
Q5CGA3_CRYHO	Q5CGA3	CHEMBL3327	Dihydrofolate Reductase, Cryho	1
Q72874_9HIV1	Q72874	CHEMBL243	Human Immunodeficiency Virus Type 1 Protease, 9hiv1	1