UCSF

Dihydrofolate Reductase, Human (895 Compounds)

Swissprot:
DYR_HUMAN
Stitch:
DYR_HUMAN
UniProt:
P00374
ChEMBL:
CHEMBL202
Reactome:
REACT_471
REACT_683
REACT_11167
REACT_111176
PDB:
1BOZ (DOCK)
1DHF (DOCK)
1DLR (DOCK)
1DLS (DOCK)
1DRF (DOCK)
1HFP (DOCK)
1HFQ (DOCK)
1HFR (DOCK)
1KMS (DOCK)
1KMV (DOCK)
1MVS (DOCK)
1MVT (DOCK)
1OHJ (DOCK)
1OHK (DOCK)
1PD8 (DOCK)
1PD9 (DOCK)
1PDB (DOCK)
1S3U (DOCK)
1S3V (DOCK)
1S3W (DOCK)
1U71 (DOCK)
1U72 (DOCK)
1YHO (DOCK)
2C2S (DOCK)
2C2T (DOCK)
2DHF (DOCK)
2W3A (DOCK)
2W3B (DOCK)
2W3M (DOCK)
3EIG (DOCK)
3F8Y (DOCK)
3F8Z (DOCK)
3F91 (DOCK)
3FS6 (DOCK)
3GHC (DOCK)
3GHV (DOCK)
3GHW (DOCK)
3GI2 (DOCK)
3GYF (DOCK)
3L3R (DOCK)
3N0H (DOCK)
3NTZ (DOCK)
3NU0 (DOCK)
3NXO (DOCK)
3NXR (DOCK)
3NXT (DOCK)
3NXV (DOCK)
3NXX (DOCK)
3NXY (DOCK)
3NZD (DOCK)
3OAF (DOCK)
3S3V (DOCK)
3S7A (DOCK)
DHFR

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 895 73 24 46
Binding ≤ 1μM 675 64 22 38
Functional ≤ 10μM 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 55

G1/S-Specific Transcription

Uniprot Swissprot Chembl Description Number Shared
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 55

Metabolism of folate and pterines

Uniprot Swissprot Chembl Description Number Shared
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 86 4 1 13
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 277 46 11 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 355 18 7 16
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 585 34 8 19
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48 3 1 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 65 11 2 7
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 47 10 4 8
DYRK2_HUMAN Q92630 CHEMBL4376 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 2, Human 43 3 2 2
DYRK3_HUMAN O43781 CHEMBL4575 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 3, Human 3 1 1 1

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 266
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 209
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 130
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 82
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 74
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 57
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 55
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 44
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 29
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 23
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 23
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 22
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 20
C3SWJ7_ECOLX C3SWJ7 CHEMBL6137 Thymidylate Synthase, Ecolx 13
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 13
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 9
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 7
FOLC_MOUSE P48760 CHEMBL2890 Folylpoly-gamma-glutamate Synthetase, Mouse 7
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 7
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 6
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 6
PUR2_MOUSE Q64737 CHEMBL3690 GAR Transformylase, Mouse 6
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 5
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 5
E2QDN0_ECOLX E2QDN0 CHEMBL1795153 Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx 4
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 4
TYSY_CRYNB P0CS13 CHEMBL4665 Thymidylate Synthase, Crynb 4
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 3
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 3
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 3
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 3
AMPC_ECOLI P00811 CHEMBL2026 Beta-lactamase, Ecoli 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
CLAT_HUMAN P28329 CHEMBL4039 Choline Acetylase, Human 1
CTRC_HUMAN Q99895 CHEMBL2386 Chymotrypsin C, Human 1
EDNRA_RAT P26684 CHEMBL4566 Endothelin Receptor ET-A, Rat 1
ENPP2_HUMAN Q13822 CHEMBL3691 Autotaxin, Human 1
FOLR1_HUMAN P15328 CHEMBL2121 Folate Receptor Alpha, Human 1
FOLR2_HUMAN P14207 CHEMBL5064 Folate Receptor Beta, Human 1
FOLR3_HUMAN P41439 CHEMBL3885 Folate Receptor Gamma, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
PUR2_HUMAN P22102 CHEMBL3972 GAR Transformylase, Human 1
Q5CGA3_CRYHO Q5CGA3 CHEMBL3327 Dihydrofolate Reductase, Cryho 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1