UCSF

Dihydrofolate Reductase, Canax (86 Compounds)

Swissprot:
DYR_CANAX
Stitch:
DYR_CANAX
UniProt:
P22906
ChEMBL:
CHEMBL2329
PDB:
1AI9 (DOCK)
1AOE (DOCK)
1IA1 (DOCK)
1IA2 (DOCK)
1IA3 (DOCK)
1IA4 (DOCK)
1M78 (DOCK)
1M79 (DOCK)
1M7A (DOCK)
3QLR (DOCK)
3QLS (DOCK)
3QLW (DOCK)
DFR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 86 4 1 13
Binding ≤ 1μM 83 4 1 13

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 895 73 24 46
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 277 46 11 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 355 18 7 16
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 585 34 8 19
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48 3 1 2

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 82
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 19
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 13
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 2
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 2
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 2
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 2
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 2
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 2
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 1
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 1

Most Common Rings