UCSF

Dihydrofolate Reductase, Yeast (48 Compounds)

Swissprot:
DYR_YEAST
Stitch:
DYR_YEAST
UniProt:
P07807
ChEMBL:
CHEMBL2576
Reactome:
REACT_252897
REACT_189247
REACT_261783
REACT_189008
PDB:
DFR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 48 3 1 2
Binding ≤ 1μM 35 2 1 2

Reactome Network (4)

Reactome ID Description Species
REACT_252897 E2F mediated regulation of DNA replication Saccharomyces cerevisiae
REACT_189247 G1/S-Specific Transcription Saccharomyces cerevisiae
REACT_261783 Metabolism of folate and pterines Saccharomyces cerevisiae
REACT_189008 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Saccharomyces cerevisiae
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 86 4 1 13
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 895 73 24 46
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 277 46 11 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 355 18 7 16
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 585 34 8 19
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 48
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 47
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 39
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 9
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 2
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 2
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 2
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 1
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 1

Most Common Rings