| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 50 | 2 | 2 | 2 |
| Binding ≤ 1μM | 33 | 2 | 2 | 2 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_201998 | E2F mediated regulation of DNA replication | Bos taurus |
| REACT_225533 | G1/S-Specific Transcription | Bos taurus |
| REACT_222884 | Metabolism of folate and pterines | Bos taurus |
| REACT_217517 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Bos taurus |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| DYR_CANAX | P22906 | CHEMBL2329 | Dihydrofolate Reductase, Canax | 86 | 4 | 1 | 13 |
| DYR_CHICK | P00378 | CHEMBL2575 | Dihydrofolate Reductase, Chick | 14 | 6 | 4 | 4 |
| DYR_ECOLI | P0ABQ4 | CHEMBL1809 | Dihydrofolate Reductase, Ecoli | 117 | 8 | 6 | 11 |
| DYR_HUMAN | P00374 | CHEMBL202 | Dihydrofolate Reductase, Human | 895 | 73 | 24 | 46 |
| DYR_LACCA | P00381 | CHEMBL2902 | Dihydrofolate Reductase, Lacca | 97 | 10 | 6 | 13 |
| DYR_MOUSE | P00375 | CHEMBL4564 | Dihydrofolate Reductase, Mouse | 277 | 46 | 11 | 13 |
| DYR_MYCTU | P0A546 | CHEMBL6065 | Dihydrofolate Reductase, Myctu | 1 | 1 | 1 | 1 |
| DYR_PNECA | P16184 | CHEMBL1926 | Dihydrofolate Reductase, Pneca | 355 | 18 | 7 | 16 |
| DYR_RAT | Q920D2 | CHEMBL2363 | Dihydrofolate Reductase, Rat | 585 | 34 | 8 | 19 |
| DYR_STAAU | P0A017 | CHEMBL1681620 | Dihydrofolate Reductase, Staau | 33 | 3 | 3 | 4 |
| DYR_STAAW | Q8NWQ9 | CHEMBL3644 | Dihydrofolate Reductase, Staaw | 12 | 0 | 0 | 0 |
| DYR_YEAST | P07807 | CHEMBL2576 | Dihydrofolate Reductase, Yeast | 48 | 3 | 1 | 2 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| DYR-1-B | Dihydrofolate Reductase (cluster #1 Of 4), Bacterial | 237 | 18 | 13 | 24 |
| DYR-1-E | Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic | 1,093 | 102 | 24 | 44 |
| DYR-1-F | Dihydrofolate Reductase (cluster #1 Of 1), Fungal | 450 | 21 | 7 | 28 |
| DYR-2-B | Dihydrofolate Reductase (cluster #2 Of 4), Bacterial | 2 | 0 | 0 | 0 |
| DYR-2-E | Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic | 165 | 9 | 2 | 3 |
| DYR-3-B | Dihydrofolate Reductase (cluster #3 Of 4), Bacterial | 1 | 1 | 1 | 1 |
| DYR-3-E | Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic | 219 | 3 | 3 | 9 |
| DYR-4-B | Dihydrofolate Reductase (cluster #4 Of 4), Bacterial | 7 | 0 | 0 | 1 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| DYR_HUMAN | P00374 | CHEMBL202 | Dihydrofolate Reductase, Human | 23 |
| B0BL08_ECOLX | B0BL08 | CHEMBL5441 | Dihydrofolate Reductase, Ecolx | 2 |
| DRTS_TOXGO | Q07422 | CHEMBL2425 | Dihydrofolate Reductase, Toxgo | 2 |
| DYR1_ECOLX | P00382 | CHEMBL2627 | Dihydrofolate Reductase Type 1, Ecolx | 2 |
| DYR_CHICK | P00378 | CHEMBL2575 | Dihydrofolate Reductase, Chick | 2 |
| DYR_ECOLI | P0ABQ4 | CHEMBL1809 | Dihydrofolate Reductase, Ecoli | 2 |
| DYR_LACCA | P00381 | CHEMBL2902 | Dihydrofolate Reductase, Lacca | 2 |
| DYR_MOUSE | P00375 | CHEMBL4564 | Dihydrofolate Reductase, Mouse | 2 |
| DYR_PNECA | P16184 | CHEMBL1926 | Dihydrofolate Reductase, Pneca | 2 |
| DYR_RAT | Q920D2 | CHEMBL2363 | Dihydrofolate Reductase, Rat | 2 |
| FOLC_HUMAN | Q05932 | CHEMBL3171 | Folylpoly-gamma-glutamate Synthetase, Human | 2 |
| PTR1_LEIMA | Q01782 | CHEMBL6194 | Pteridine Reductase 1, Leima | 2 |
| Q81R22_BACAN | Q81R22 | CHEMBL5270 | Dihydrofolate Reductase, Bacan | 2 |
| S19A1_HUMAN | P41440 | CHEMBL4833 | Folate Transporter 1, Human | 2 |
| TYSY_ECOLI | P0A884 | CHEMBL2555 | Thymidylate Synthase, Ecoli | 2 |
| TYSY_HUMAN | P04818 | CHEMBL1952 | Thymidylate Synthase, Human | 2 |