UCSF

Thymidylate Synthase, Human (443 Compounds)

Swissprot:
TYSY_HUMAN
Stitch:
TYSY_HUMAN
UniProt:
P04818
ChEMBL:
CHEMBL1952
Reactome:
REACT_471
REACT_683
REACT_21376
PDB:
1HVY (DOCK)
1HW3 (DOCK)
1HW4 (DOCK)
1HZW (DOCK)
1I00 (DOCK)
1JU6 (DOCK)
1JUJ (DOCK)
1YPV (DOCK)
2ONB (DOCK)
2RD8 (DOCK)
2RDA (DOCK)
3EAW (DOCK)
3EBU (DOCK)
3ED7 (DOCK)
3EDW (DOCK)
3EF9 (DOCK)
3EGY (DOCK)
3EHI (DOCK)
3EJL (DOCK)
3GG5 (DOCK)
3GH0 (DOCK)
3GH2 (DOCK)
3H9K (DOCK)
3HB8 (DOCK)
3N5E (DOCK)
3N5G (DOCK)
3OB7 (DOCK)
TYMS

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 443 18 12 14
Binding ≤ 1μM 293 9 5 11

Reactome Network (3)

Reactome ID Description Species
REACT_471 E2F mediated regulation of DNA replication Homo sapiens
REACT_683 G1/S-Specific Transcription Homo sapiens
REACT_21376 Pyrimidine biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 55

G1/S-Specific Transcription

Uniprot Swissprot Chembl Description Number Shared
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 55
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TYSY_CRYNB P0CS13 CHEMBL4665 Thymidylate Synthase, Crynb 14 0 0 0
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 96 7 6 9
TYSY_ENTFA Q834R3 CHEMBL1795144 Thymidylate Synthase, Entfa 4 1 1 4
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 102 2 2 6
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 417 22 13 29
TYSY_MYCTU P67044 CHEMBL1795162 Thymidylate Synthase, Myctu 1 0 1 1
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 4 1 2 3

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
TYSY-1-B Thymidylate Synthase (cluster #1 Of 1), Bacterial 180 8 8 17
TYSY-1-E Thymidylate Synthase (cluster #1 Of 3), Eukaryotic 764 33 22 36
TYSY-1-O Thymidylate Synthase (cluster #1 Of 1), Other 14 0 0 0
TYSY-2-E Thymidylate Synthase (cluster #2 Of 3), Eukaryotic 1 0 0 0
TYSY-3-E Thymidylate Synthase (cluster #3 Of 3), Eukaryotic 1 1 1 1
Uniprot Swissprot Chembl Description Number Shared
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 108
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 64
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 55
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 39
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 22
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 17
C3SWJ7_ECOLX C3SWJ7 CHEMBL6137 Thymidylate Synthase, Ecolx 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 10
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 7
E2QDN0_ECOLX E2QDN0 CHEMBL1795153 Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx 7
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 6
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 4
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 4
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 3
PUR2_HUMAN P22102 CHEMBL3972 GAR Transformylase, Human 3
TYSY_CRYNB P0CS13 CHEMBL4665 Thymidylate Synthase, Crynb 3
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 2
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 2
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 2
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 2
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 2
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
PUR2_MOUSE Q64737 CHEMBL3690 GAR Transformylase, Mouse 2
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 2
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 2
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
TYSY_ENTFA Q834R3 CHEMBL1795144 Thymidylate Synthase, Entfa 1

Most Common Rings