| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 417 | 22 | 13 | 29 |
| Binding ≤ 1μM | 311 | 20 | 7 | 24 |
| Functional ≤ 10μM | 8 | 0 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_206830 | E2F mediated regulation of DNA replication | Mus musculus |
| REACT_198608 | G1/S-Specific Transcription | Mus musculus |
| REACT_238763 | Pyrimidine biosynthesis | Mus musculus |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| DYR_MOUSE | P00375 | CHEMBL4564 | Dihydrofolate Reductase, Mouse | 6 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| DYR_MOUSE | P00375 | CHEMBL4564 | Dihydrofolate Reductase, Mouse | 6 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| TYSY_CRYNB | P0CS13 | CHEMBL4665 | Thymidylate Synthase, Crynb | 14 | 0 | 0 | 0 |
| TYSY_ECOLI | P0A884 | CHEMBL2555 | Thymidylate Synthase, Ecoli | 96 | 7 | 6 | 9 |
| TYSY_ENTFA | Q834R3 | CHEMBL1795144 | Thymidylate Synthase, Entfa | 4 | 1 | 1 | 4 |
| TYSY_HUMAN | P04818 | CHEMBL1952 | Thymidylate Synthase, Human | 443 | 18 | 12 | 14 |
| TYSY_LACCA | P00469 | CHEMBL5328 | Thymidylate Synthase, Lacca | 102 | 2 | 2 | 6 |
| TYSY_MYCTU | P67044 | CHEMBL1795162 | Thymidylate Synthase, Myctu | 1 | 0 | 1 | 1 |
| TYSY_RAT | P45352 | CHEMBL4341 | Thymidylate Synthase, Rat | 4 | 1 | 2 | 3 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| TYSY-1-B | Thymidylate Synthase (cluster #1 Of 1), Bacterial | 180 | 8 | 8 | 17 |
| TYSY-1-E | Thymidylate Synthase (cluster #1 Of 3), Eukaryotic | 764 | 33 | 22 | 36 |
| TYSY-1-O | Thymidylate Synthase (cluster #1 Of 1), Other | 14 | 0 | 0 | 0 |
| TYSY-2-E | Thymidylate Synthase (cluster #2 Of 3), Eukaryotic | 1 | 0 | 0 | 0 |
| TYSY-3-E | Thymidylate Synthase (cluster #3 Of 3), Eukaryotic | 1 | 1 | 1 | 1 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| TYSY_HUMAN | P04818 | CHEMBL1952 | Thymidylate Synthase, Human | 108 |
| TYSY_LACCA | P00469 | CHEMBL5328 | Thymidylate Synthase, Lacca | 9 |
| PUR2_MOUSE | Q64737 | CHEMBL3690 | GAR Transformylase, Mouse | 7 |
| DYR_MOUSE | P00375 | CHEMBL4564 | Dihydrofolate Reductase, Mouse | 6 |
| PUR2_HUMAN | P22102 | CHEMBL3972 | GAR Transformylase, Human | 6 |
| TYSY_ECOLI | P0A884 | CHEMBL2555 | Thymidylate Synthase, Ecoli | 6 |
| DYR_RAT | Q920D2 | CHEMBL2363 | Dihydrofolate Reductase, Rat | 5 |
| DRTS_TOXGO | Q07422 | CHEMBL2425 | Dihydrofolate Reductase, Toxgo | 4 |
| DYR_LACCA | P00381 | CHEMBL2902 | Dihydrofolate Reductase, Lacca | 4 |
| Z80193 | Z80193 | CHEMBL386 | L1210 (Lymphocytic Leukemia Cells) | 4 |
| DYR_HUMAN | P00374 | CHEMBL202 | Dihydrofolate Reductase, Human | 3 |
| TYSY_RAT | P45352 | CHEMBL4341 | Thymidylate Synthase, Rat | 3 |
| C3SWJ7_ECOLX | C3SWJ7 | CHEMBL6137 | Thymidylate Synthase, Ecolx | 1 |
| DYR_ECOLI | P0ABQ4 | CHEMBL1809 | Dihydrofolate Reductase, Ecoli | 1 |
| E2QDN0_ECOLX | E2QDN0 | CHEMBL1795153 | Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx | 1 |
| FOLC_MOUSE | P48760 | CHEMBL2890 | Folylpoly-gamma-glutamate Synthetase, Mouse | 1 |
| KTHY_MYCTU | O05891 | CHEMBL2361 | Thymidylate Kinase, Myctu | 1 |
| THYX_MYCTU | P66930 | CHEMBL1795161 | Thymidylate Synthase ThyX, Myctu | 1 |
| TYSY_MYCTU | P67044 | CHEMBL1795162 | Thymidylate Synthase, Myctu | 1 |
