ZINC 12

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Swissprot:: TYSY_ECOLI
Stitch:: TYSY_ECOLI
UniProt:: P0A884
ChEMBL:: CHEMBL2555
PDB:: 1AIQ (DOCK); 1AJM (DOCK); 1AN5 (DOCK); 1AOB (DOCK); 1AXW (DOCK); 1BDU (DOCK); 1BID (DOCK); 1BJG (DOCK); 1BQ1 (DOCK); 1BQ2 (DOCK); 1DDU (DOCK); 1DNA (DOCK); 1EV5 (DOCK); 1EV8 (DOCK); 1EVF (DOCK); 1EVG (DOCK); 1F4B (DOCK); 1F4C (DOCK); 1F4D (DOCK); 1F4E (DOCK); 1F4F (DOCK); 1F4G (DOCK); 1FFL (DOCK); 1FWM (DOCK); 1JG0 (DOCK); 1JTQ (DOCK); 1JTU (DOCK); 1JUT (DOCK); 1KCE (DOCK); 1KZI (DOCK); 1KZJ (DOCK); 1NCE (DOCK); 1QQQ (DOCK); 1SYN (DOCK); 1TDU (DOCK); 1TJS (DOCK); 1TLC (DOCK); 1TLS (DOCK); 1TRG (DOCK); 1TSD (DOCK); 1TSN (DOCK); 1TYS (DOCK); 1ZPR (DOCK); 2A9W (DOCK); 2BBQ (DOCK); 2FTN (DOCK); 2FTO (DOCK); 2FTQ (DOCK); 2G8M (DOCK); 2G8O (DOCK); 2G8X (DOCK); 2KCE (DOCK); 2TSC (DOCK); 2VET (DOCK); 2VF0 (DOCK); 3B5B (DOCK); 3B9H (DOCK); 3BFI (DOCK); 3BGX (DOCK); 3BHL (DOCK); 3BHR (DOCK); 3TMS (DOCK)

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	96	7	6	9
Binding ≤ 1μM	49	1	1	4

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
TYSY_CRYNB	P0CS13	CHEMBL4665	Thymidylate Synthase, Crynb	14	0	0	0
TYSY_ENTFA	Q834R3	CHEMBL1795144	Thymidylate Synthase, Entfa	4	1	1	4
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	443	18	12	14
TYSY_LACCA	P00469	CHEMBL5328	Thymidylate Synthase, Lacca	102	2	2	6
TYSY_MOUSE	P07607	CHEMBL3160	Thymidylate Synthase, Mouse	417	22	13	29
TYSY_MYCTU	P67044	CHEMBL1795162	Thymidylate Synthase, Myctu	1	0	1	1
TYSY_RAT	P45352	CHEMBL4341	Thymidylate Synthase, Rat	4	1	2	3

Code	Description	Substances	Purchasable	Natural	In Man
TYSY-1-B	Thymidylate Synthase (cluster #1 Of 1), Bacterial	180	8	8	17
TYSY-1-E	Thymidylate Synthase (cluster #1 Of 3), Eukaryotic	764	33	22	36
TYSY-1-O	Thymidylate Synthase (cluster #1 Of 1), Other	14	0	0	0
TYSY-2-E	Thymidylate Synthase (cluster #2 Of 3), Eukaryotic	1	0	0	0
TYSY-3-E	Thymidylate Synthase (cluster #3 Of 3), Eukaryotic	1	1	1	1

Uniprot	Swissprot	Chembl	Description	Number Shared
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	64
TYSY_LACCA	P00469	CHEMBL5328	Thymidylate Synthase, Lacca	23
DYR_HUMAN	P00374	CHEMBL202	Dihydrofolate Reductase, Human	20
DRTS_TOXGO	Q07422	CHEMBL2425	Dihydrofolate Reductase, Toxgo	14
TYSY_CRYNB	P0CS13	CHEMBL4665	Thymidylate Synthase, Crynb	12
TYSY_MOUSE	P07607	CHEMBL3160	Thymidylate Synthase, Mouse	6
B0BL08_ECOLX	B0BL08	CHEMBL5441	Dihydrofolate Reductase, Ecolx	4
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	4
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	4
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	4
DYR_ECOLI	P0ABQ4	CHEMBL1809	Dihydrofolate Reductase, Ecoli	3
TYSY_RAT	P45352	CHEMBL4341	Thymidylate Synthase, Rat	3
DYR1_ECOLX	P00382	CHEMBL2627	Dihydrofolate Reductase Type 1, Ecolx	2
DYR_BOVIN	P00376	CHEMBL1075051	Dihydrofolate Reductase, Bovin	2
DYR_CHICK	P00378	CHEMBL2575	Dihydrofolate Reductase, Chick	2
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	2
E2QDN0_ECOLX	E2QDN0	CHEMBL1795153	Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx	2
FOLC_HUMAN	Q05932	CHEMBL3171	Folylpoly-gamma-glutamate Synthetase, Human	2
PTR1_LEIMA	Q01782	CHEMBL6194	Pteridine Reductase 1, Leima	2
PUR2_MOUSE	Q64737	CHEMBL3690	GAR Transformylase, Mouse	2
Q81R22_BACAN	Q81R22	CHEMBL5270	Dihydrofolate Reductase, Bacan	2
S19A1_HUMAN	P41440	CHEMBL4833	Folate Transporter 1, Human	2
C3SWJ7_ECOLX	C3SWJ7	CHEMBL6137	Thymidylate Synthase, Ecolx	1
PUR2_HUMAN	P22102	CHEMBL3972	GAR Transformylase, Human	1
TYSY_ENTFA	Q834R3	CHEMBL1795144	Thymidylate Synthase, Entfa	1