| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 277 | 46 | 11 | 13 |
| Binding ≤ 1μM | 267 | 46 | 11 | 13 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_206830 | E2F mediated regulation of DNA replication | Mus musculus |
| REACT_198608 | G1/S-Specific Transcription | Mus musculus |
| REACT_220137 | Metabolism of folate and pterines | Mus musculus |
| REACT_199047 | Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Mus musculus |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| TYSY_MOUSE | P07607 | CHEMBL3160 | Thymidylate Synthase, Mouse | 6 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| TYSY_MOUSE | P07607 | CHEMBL3160 | Thymidylate Synthase, Mouse | 6 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| FOLC_MOUSE | P48760 | CHEMBL2890 | Folylpoly-gamma-glutamate Synthetase, Mouse | 3 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| DYR_BOVIN | P00376 | CHEMBL1075051 | Dihydrofolate Reductase, Bovin | 50 | 2 | 2 | 2 |
| DYR_CANAX | P22906 | CHEMBL2329 | Dihydrofolate Reductase, Canax | 86 | 4 | 1 | 13 |
| DYR_CHICK | P00378 | CHEMBL2575 | Dihydrofolate Reductase, Chick | 14 | 6 | 4 | 4 |
| DYR_ECOLI | P0ABQ4 | CHEMBL1809 | Dihydrofolate Reductase, Ecoli | 117 | 8 | 6 | 11 |
| DYR_HUMAN | P00374 | CHEMBL202 | Dihydrofolate Reductase, Human | 895 | 73 | 24 | 46 |
| DYR_LACCA | P00381 | CHEMBL2902 | Dihydrofolate Reductase, Lacca | 97 | 10 | 6 | 13 |
| DYR_MYCTU | P0A546 | CHEMBL6065 | Dihydrofolate Reductase, Myctu | 1 | 1 | 1 | 1 |
| DYR_PNECA | P16184 | CHEMBL1926 | Dihydrofolate Reductase, Pneca | 355 | 18 | 7 | 16 |
| DYR_RAT | Q920D2 | CHEMBL2363 | Dihydrofolate Reductase, Rat | 585 | 34 | 8 | 19 |
| DYR_STAAU | P0A017 | CHEMBL1681620 | Dihydrofolate Reductase, Staau | 33 | 3 | 3 | 4 |
| DYR_STAAW | Q8NWQ9 | CHEMBL3644 | Dihydrofolate Reductase, Staaw | 12 | 0 | 0 | 0 |
| DYR_YEAST | P07807 | CHEMBL2576 | Dihydrofolate Reductase, Yeast | 48 | 3 | 1 | 2 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| DYR1A_MOUSE | Q61214 | CHEMBL4750 | Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Mouse | 7 | 5 | 0 | 1 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| DYR-1-B | Dihydrofolate Reductase (cluster #1 Of 4), Bacterial | 237 | 18 | 13 | 24 |
| DYR-1-E | Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic | 1,093 | 102 | 24 | 44 |
| DYR-1-F | Dihydrofolate Reductase (cluster #1 Of 1), Fungal | 450 | 21 | 7 | 28 |
| DYR-2-B | Dihydrofolate Reductase (cluster #2 Of 4), Bacterial | 2 | 0 | 0 | 0 |
| DYR-2-E | Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic | 165 | 9 | 2 | 3 |
| DYR-3-B | Dihydrofolate Reductase (cluster #3 Of 4), Bacterial | 1 | 1 | 1 | 1 |
| DYR-3-E | Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic | 219 | 3 | 3 | 9 |
| DYR-4-B | Dihydrofolate Reductase (cluster #4 Of 4), Bacterial | 7 | 0 | 0 | 1 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| DYR_HUMAN | P00374 | CHEMBL202 | Dihydrofolate Reductase, Human | 57 |
| DYR_RAT | Q920D2 | CHEMBL2363 | Dihydrofolate Reductase, Rat | 39 |
| DYR_LACCA | P00381 | CHEMBL2902 | Dihydrofolate Reductase, Lacca | 21 |
| DRTS_TOXGO | Q07422 | CHEMBL2425 | Dihydrofolate Reductase, Toxgo | 18 |
| TYSY_HUMAN | P04818 | CHEMBL1952 | Thymidylate Synthase, Human | 10 |
| DYR_CHICK | P00378 | CHEMBL2575 | Dihydrofolate Reductase, Chick | 6 |
| TYSY_MOUSE | P07607 | CHEMBL3160 | Thymidylate Synthase, Mouse | 6 |
| TYSY_LACCA | P00469 | CHEMBL5328 | Thymidylate Synthase, Lacca | 5 |
| DYR_ECOLI | P0ABQ4 | CHEMBL1809 | Dihydrofolate Reductase, Ecoli | 4 |
| DYR_PNECA | P16184 | CHEMBL1926 | Dihydrofolate Reductase, Pneca | 4 |
| TYSY_ECOLI | P0A884 | CHEMBL2555 | Thymidylate Synthase, Ecoli | 4 |
| B0BL08_ECOLX | B0BL08 | CHEMBL5441 | Dihydrofolate Reductase, Ecolx | 3 |
| DYR1_ECOLX | P00382 | CHEMBL2627 | Dihydrofolate Reductase Type 1, Ecolx | 3 |
| FOLC_HUMAN | Q05932 | CHEMBL3171 | Folylpoly-gamma-glutamate Synthetase, Human | 3 |
| FOLC_MOUSE | P48760 | CHEMBL2890 | Folylpoly-gamma-glutamate Synthetase, Mouse | 3 |
| DYR_BOVIN | P00376 | CHEMBL1075051 | Dihydrofolate Reductase, Bovin | 2 |
| EGFR_HUMAN | P00533 | CHEMBL203 | Epidermal Growth Factor Receptor ErbB1, Human | 2 |
| O30463_MYCAV | O30463 | CHEMBL5457 | Dihydrofolate Reductase, Mycav | 2 |
| PTR1_LEIMA | Q01782 | CHEMBL6194 | Pteridine Reductase 1, Leima | 2 |
| PUR2_MOUSE | Q64737 | CHEMBL3690 | GAR Transformylase, Mouse | 2 |
| Q81R22_BACAN | Q81R22 | CHEMBL5270 | Dihydrofolate Reductase, Bacan | 2 |
| S19A1_HUMAN | P41440 | CHEMBL4833 | Folate Transporter 1, Human | 2 |
| TYSY_RAT | P45352 | CHEMBL4341 | Thymidylate Synthase, Rat | 2 |
| VGFR2_HUMAN | P35968 | CHEMBL279 | Vascular Endothelial Growth Factor Receptor 2, Human | 2 |
| C3SWJ7_ECOLX | C3SWJ7 | CHEMBL6137 | Thymidylate Synthase, Ecolx | 1 |
| DRTS_PLAFK | P13922 | CHEMBL1939 | Dihydrofolate Reductase, Plafk | 1 |
| DRTS_TRYCR | Q27793 | CHEMBL1163130 | Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr | 1 |
| DYR_CANAX | P22906 | CHEMBL2329 | Dihydrofolate Reductase, Canax | 1 |
| DYR_STAAU | P0A017 | CHEMBL1681620 | Dihydrofolate Reductase, Staau | 1 |
| DYR_YEAST | P07807 | CHEMBL2576 | Dihydrofolate Reductase, Yeast | 1 |
| E2QDN0_ECOLX | E2QDN0 | CHEMBL1795153 | Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx | 1 |
| KCNH2_HUMAN | Q12809 | CHEMBL240 | HERG, Human | 1 |
| XDH_BOVIN | P80457 | CHEMBL3649 | Xanthine Dehydrogenase, Bovin | 1 |