ZINC 12

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Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	184	41	5	7
Binding ≤ 1μM	175	35	5	7
Functional ≤ 10μM	67	9	2	3

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DRTS_TOXGO	Q07422	CHEMBL2425	Dihydrofolate Reductase, Toxgo	539	22	9	17
DRTS_TRYCR	Q27793	CHEMBL1163130	Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr	7	1	1	1

Code	Description	Substances	Purchasable	Natural	In Man
DRTS-1-E	Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #1 Of 3), Eukaryotic	638	47	13	22
DRTS-2-E	Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #2 Of 3), Eukaryotic	2	2	0	0
DRTS-3-E	Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #3 Of 3), Eukaryotic	92	13	1	2

Uniprot	Swissprot	Chembl	Description	Number Shared
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	62
Z81115	Z81115	CHEMBL398	KB (Squamous Cell Carcinoma)	29
Z80691	Z80691	CHEMBL613535	BC Cell Line	27
DYR_HUMAN	P00374	CHEMBL202	Dihydrofolate Reductase, Human	6
Z80583	Z80583	CHEMBL391	Vero (Kidney Cells)	4
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	3
DRTS_TOXGO	Q07422	CHEMBL2425	Dihydrofolate Reductase, Toxgo	2
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	2
Z50418	Z50418	CHEMBL612849	Trypanosoma Brucei	2
B0BL08_ECOLX	B0BL08	CHEMBL5441	Dihydrofolate Reductase, Ecolx	1
DYR1_ECOLX	P00382	CHEMBL2627	Dihydrofolate Reductase Type 1, Ecolx	1
DYR_ECOLI	P0ABQ4	CHEMBL1809	Dihydrofolate Reductase, Ecoli	1
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	1
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	1
DYR_STAAU	P0A017	CHEMBL1681620	Dihydrofolate Reductase, Staau	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
O30463_MYCAV	O30463	CHEMBL5457	Dihydrofolate Reductase, Mycav	1
Z50339	Z50339	CHEMBL613064	Pneumocystis Carinii	1
Z50426	Z50426	CHEMBL612856	Plasmodium Falciparum (isolate K1 / Thailand)	1
Z50472	Z50472	CHEMBL612888	Toxoplasma Gondii	1