UCSF

Dihydrofolate Reductase, Rat (585 Compounds)

Swissprot:
DYR_RAT
Stitch:
DYR_RAT
UniProt:
Q920D2
ChEMBL:
CHEMBL2363
Reactome:
REACT_249225
REACT_196414
REACT_246418
REACT_199128
PDB:
Dhfr

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 585 34 8 19
Binding ≤ 1μM 385 29 7 17
Functional ≤ 10μM 1 0 0 0

Reactome Network (4)

Reactome ID Description Species
REACT_249225 E2F mediated regulation of DNA replication Rattus norvegicus
REACT_196414 G1/S-Specific Transcription Rattus norvegicus
REACT_246418 Metabolism of folate and pterines Rattus norvegicus
REACT_199128 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 2

G1/S-Specific Transcription

Uniprot Swissprot Chembl Description Number Shared
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 50 2 2 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 86 4 1 13
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 14 6 4 4
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 117 8 6 11
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 895 73 24 46
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 97 10 6 13
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 277 46 11 13
DYR_MYCTU P0A546 CHEMBL6065 Dihydrofolate Reductase, Myctu 1 1 1 1
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 355 18 7 16
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 33 3 3 4
DYR_STAAW Q8NWQ9 CHEMBL3644 Dihydrofolate Reductase, Staaw 12 0 0 0
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48 3 1 2
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DYR1A_RAT Q63470 CHEMBL5508 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A, Rat 98 1 2 2

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
DYR-1-B Dihydrofolate Reductase (cluster #1 Of 4), Bacterial 237 18 13 24
DYR-1-E Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic 1,093 102 24 44
DYR-1-F Dihydrofolate Reductase (cluster #1 Of 1), Fungal 450 21 7 28
DYR-2-B Dihydrofolate Reductase (cluster #2 Of 4), Bacterial 2 0 0 0
DYR-2-E Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic 165 9 2 3
DYR-3-B Dihydrofolate Reductase (cluster #3 Of 4), Bacterial 1 1 1 1
DYR-3-E Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic 219 3 3 9
DYR-4-B Dihydrofolate Reductase (cluster #4 Of 4), Bacterial 7 0 0 1
Uniprot Swissprot Chembl Description Number Shared
DRTS_TOXGO Q07422 CHEMBL2425 Dihydrofolate Reductase, Toxgo 411
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 329
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 266
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 48
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 47
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 39
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 39
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 18
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 9
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 6
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 5
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 4
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 4
FOLC_MOUSE P48760 CHEMBL2890 Folylpoly-gamma-glutamate Synthetase, Mouse 3
PUR2_MOUSE Q64737 CHEMBL3690 GAR Transformylase, Mouse 3
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 2
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 2
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 2
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 2
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 2
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 2
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 2
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2
C3SWJ7_ECOLX C3SWJ7 CHEMBL6137 Thymidylate Synthase, Ecolx 1
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
E2QDN0_ECOLX E2QDN0 CHEMBL1795153 Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx 1
PUR2_HUMAN P22102 CHEMBL3972 GAR Transformylase, Human 1
Q5CGA3_CRYHO Q5CGA3 CHEMBL3327 Dihydrofolate Reductase, Cryho 1

Most Common Rings