UCSF

Dihydrofolate Reductase, Toxgo (539 Compounds)

Swissprot:
DRTS_TOXGO
Stitch:
DRTS_TOXGO
UniProt:
Q07422
ChEMBL:
CHEMBL2425

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 539 22 9 17
Binding ≤ 1μM 409 21 8 16

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 184 41 5 7
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 7 1 1 1

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
DRTS-1-E Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #1 Of 3), Eukaryotic 638 47 13 22
DRTS-2-E Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #2 Of 3), Eukaryotic 2 2 0 0
DRTS-3-E Bifunctional Dihydrofolate Reductase-thymidylate Synthase (cluster #3 Of 3), Eukaryotic 92 13 1 2
Uniprot Swissprot Chembl Description Number Shared
DYR_RAT Q920D2 CHEMBL2363 Dihydrofolate Reductase, Rat 411
DYR_PNECA P16184 CHEMBL1926 Dihydrofolate Reductase, Pneca 335
DYR_HUMAN P00374 CHEMBL202 Dihydrofolate Reductase, Human 209
O30463_MYCAV O30463 CHEMBL5457 Dihydrofolate Reductase, Mycav 54
DYR_YEAST P07807 CHEMBL2576 Dihydrofolate Reductase, Yeast 48
TYSY_HUMAN P04818 CHEMBL1952 Thymidylate Synthase, Human 39
DYR_ECOLI P0ABQ4 CHEMBL1809 Dihydrofolate Reductase, Ecoli 37
DYR_MOUSE P00375 CHEMBL4564 Dihydrofolate Reductase, Mouse 18
TYSY_ECOLI P0A884 CHEMBL2555 Thymidylate Synthase, Ecoli 14
C3SWJ7_ECOLX C3SWJ7 CHEMBL6137 Thymidylate Synthase, Ecolx 13
DYR_CANAX P22906 CHEMBL2329 Dihydrofolate Reductase, Canax 13
DYR_LACCA P00381 CHEMBL2902 Dihydrofolate Reductase, Lacca 12
Q81R22_BACAN Q81R22 CHEMBL5270 Dihydrofolate Reductase, Bacan 9
E2QDN0_ECOLX E2QDN0 CHEMBL1795153 Thymidylate Synthase (EC 2.1.1.45) (TS) (TSase), Ecolx 7
B0BL08_ECOLX B0BL08 CHEMBL5441 Dihydrofolate Reductase, Ecolx 5
TYSY_MOUSE P07607 CHEMBL3160 Thymidylate Synthase, Mouse 4
DYR1_ECOLX P00382 CHEMBL2627 Dihydrofolate Reductase Type 1, Ecolx 3
TYSY_RAT P45352 CHEMBL4341 Thymidylate Synthase, Rat 3
DRTS_PLAFK P13922 CHEMBL1939 Dihydrofolate Reductase, Plafk 2
DYR_BOVIN P00376 CHEMBL1075051 Dihydrofolate Reductase, Bovin 2
DYR_CHICK P00378 CHEMBL2575 Dihydrofolate Reductase, Chick 2
FOLC_HUMAN Q05932 CHEMBL3171 Folylpoly-gamma-glutamate Synthetase, Human 2
PTR1_LEIMA Q01782 CHEMBL6194 Pteridine Reductase 1, Leima 2
PUR2_MOUSE Q64737 CHEMBL3690 GAR Transformylase, Mouse 2
S19A1_HUMAN P41440 CHEMBL4833 Folate Transporter 1, Human 2
TYSY_LACCA P00469 CHEMBL5328 Thymidylate Synthase, Lacca 2
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2
DRTS_TRYCR Q27793 CHEMBL1163130 Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr 1
DYR_STAAU P0A017 CHEMBL1681620 Dihydrofolate Reductase, Staau 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PUR2_HUMAN P22102 CHEMBL3972 GAR Transformylase, Human 1
Q5CGA3_CRYHO Q5CGA3 CHEMBL3327 Dihydrofolate Reductase, Cryho 1

Most Common Rings