ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (117)
Reactome (0)
Related By:
Pathway (0)
Organism (12)
Gene (0)
Org. Clust. (7)
ChEMBL (26)
Rings (12)

Dihydrofolate Reductase, Ecoli (117 Compounds)

Swissprot:: DYR_ECOLI
Stitch:: DYR_ECOLI
UniProt:: P0ABQ4
ChEMBL:: CHEMBL1809
PDB:: 1DDR (DOCK); 1DDS (DOCK); 1DHI (DOCK); 1DHJ (DOCK); 1DRA (DOCK); 1DRB (DOCK); 1DRE (DOCK); 1DRH (DOCK); 1DYH (DOCK); 1DYI (DOCK); 1DYJ (DOCK); 1JOL (DOCK); 1JOM (DOCK); 1RA1 (DOCK); 1RA2 (DOCK); 1RA3 (DOCK); 1RA8 (DOCK); 1RA9 (DOCK); 1RB2 (DOCK); 1RB3 (DOCK); 1RC4 (DOCK); 1RD7 (DOCK); 1RE7 (DOCK); 1RF7 (DOCK); 1RG7 (DOCK); 1RH3 (DOCK); 1RX1 (DOCK); 1RX2 (DOCK); 1RX3 (DOCK); 1RX4 (DOCK); 1RX5 (DOCK); 1RX6 (DOCK); 1RX7 (DOCK); 1RX8 (DOCK); 1RX9 (DOCK); 1TDR (DOCK); 2ANO (DOCK); 2ANQ (DOCK); 2D0K (DOCK); 2DRC (DOCK); 2INQ (DOCK); 3DAU (DOCK); 3DRC (DOCK); 3K74 (DOCK); 3KFY (DOCK); 3OCH (DOCK); 3QL3 (DOCK); 3QYL (DOCK); 3QYO (DOCK); 3R33 (DOCK); 4DFR (DOCK); 5DFR (DOCK); 6DFR (DOCK); 7DFR (DOCK)

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	117	8	6	11
Binding ≤ 1μM	76	5	4	7

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DYR_BOVIN	P00376	CHEMBL1075051	Dihydrofolate Reductase, Bovin	50	2	2	2
DYR_CANAX	P22906	CHEMBL2329	Dihydrofolate Reductase, Canax	86	4	1	13
DYR_CHICK	P00378	CHEMBL2575	Dihydrofolate Reductase, Chick	14	6	4	4
DYR_HUMAN	P00374	CHEMBL202	Dihydrofolate Reductase, Human	895	73	24	46
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	97	10	6	13
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	277	46	11	13
DYR_MYCTU	P0A546	CHEMBL6065	Dihydrofolate Reductase, Myctu	1	1	1	1
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	355	18	7	16
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	585	34	8	19
DYR_STAAU	P0A017	CHEMBL1681620	Dihydrofolate Reductase, Staau	33	3	3	4
DYR_STAAW	Q8NWQ9	CHEMBL3644	Dihydrofolate Reductase, Staaw	12	0	0	0
DYR_YEAST	P07807	CHEMBL2576	Dihydrofolate Reductase, Yeast	48	3	1	2

Clustered By Gene (0)

Clustered By Organism (7)

Code	Description	Substances	Purchasable	Natural	In Man
DYR-1-B	Dihydrofolate Reductase (cluster #1 Of 4), Bacterial	237	18	13	24
DYR-1-E	Dihydrofolate Reductase (cluster #1 Of 3), Eukaryotic	1,093	102	24	44
DYR-1-F	Dihydrofolate Reductase (cluster #1 Of 1), Fungal	450	21	7	28
DYR-2-B	Dihydrofolate Reductase (cluster #2 Of 4), Bacterial	2	0	0	0
DYR-2-E	Dihydrofolate Reductase (cluster #2 Of 3), Eukaryotic	165	9	2	3
DYR-3-B	Dihydrofolate Reductase (cluster #3 Of 4), Bacterial	1	1	1	1
DYR-3-E	Dihydrofolate Reductase (cluster #3 Of 3), Eukaryotic	219	3	3	9
DYR-4-B	Dihydrofolate Reductase (cluster #4 Of 4), Bacterial	7	0	0	1

Uniprot	Swissprot	Chembl	Description	Number Shared
DYR_HUMAN	P00374	CHEMBL202	Dihydrofolate Reductase, Human	74
DYR_RAT	Q920D2	CHEMBL2363	Dihydrofolate Reductase, Rat	39
DRTS_TOXGO	Q07422	CHEMBL2425	Dihydrofolate Reductase, Toxgo	37
DYR_PNECA	P16184	CHEMBL1926	Dihydrofolate Reductase, Pneca	20
DYR_LACCA	P00381	CHEMBL2902	Dihydrofolate Reductase, Lacca	18
DYR1_ECOLX	P00382	CHEMBL2627	Dihydrofolate Reductase Type 1, Ecolx	17
TYSY_HUMAN	P04818	CHEMBL1952	Thymidylate Synthase, Human	7
O30463_MYCAV	O30463	CHEMBL5457	Dihydrofolate Reductase, Mycav	5
DYR_MOUSE	P00375	CHEMBL4564	Dihydrofolate Reductase, Mouse	4
B0BL08_ECOLX	B0BL08	CHEMBL5441	Dihydrofolate Reductase, Ecolx	3
TYSY_ECOLI	P0A884	CHEMBL2555	Thymidylate Synthase, Ecoli	3
DYR_BOVIN	P00376	CHEMBL1075051	Dihydrofolate Reductase, Bovin	2
DYR_CANAX	P22906	CHEMBL2329	Dihydrofolate Reductase, Canax	2
DYR_CHICK	P00378	CHEMBL2575	Dihydrofolate Reductase, Chick	2
DYR_YEAST	P07807	CHEMBL2576	Dihydrofolate Reductase, Yeast	2
FOLC_HUMAN	Q05932	CHEMBL3171	Folylpoly-gamma-glutamate Synthetase, Human	2
PTR1_LEIMA	Q01782	CHEMBL6194	Pteridine Reductase 1, Leima	2
Q81R22_BACAN	Q81R22	CHEMBL5270	Dihydrofolate Reductase, Bacan	2
S19A1_HUMAN	P41440	CHEMBL4833	Folate Transporter 1, Human	2
DRTS_PLAFK	P13922	CHEMBL1939	Dihydrofolate Reductase, Plafk	1
DRTS_TRYCR	Q27793	CHEMBL1163130	Bifunctional Dihydrofolate Reductase-thymidylate Synthase, Trycr	1
DYR_STAAU	P0A017	CHEMBL1681620	Dihydrofolate Reductase, Staau	1
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	1
PUR2_HUMAN	P22102	CHEMBL3972	GAR Transformylase, Human	1
TYSY_MOUSE	P07607	CHEMBL3160	Thymidylate Synthase, Mouse	1
TYSY_RAT	P45352	CHEMBL4341	Thymidylate Synthase, Rat	1