UCSF

Apoptosis Regulator Bcl-X, Human (121 Compounds)

Swissprot:
B2CL1_HUMAN
Stitch:
B2CL1_HUMAN
UniProt:
Q07817
ChEMBL:
CHEMBL4625
Reactome:
REACT_330
REACT_75927
PDB:
1BXL (DOCK)
1G5J (DOCK)
1LXL (DOCK)
1MAZ (DOCK)
1R2D (DOCK)
1R2E (DOCK)
1R2G (DOCK)
1R2H (DOCK)
1R2I (DOCK)
1YSG (DOCK)
1YSI (DOCK)
1YSN (DOCK)
2B48 (DOCK)
2O1Y (DOCK)
2O2M (DOCK)
2O2N (DOCK)
2P1L (DOCK)
2PON (DOCK)
2YJ1 (DOCK)
2YXJ (DOCK)
3CVA (DOCK)
3FDL (DOCK)
3FDM (DOCK)
3INQ (DOCK)
3IO8 (DOCK)
3PL7 (DOCK)
3QKD (DOCK)
3R85 (DOCK)
4A1U (DOCK)
4A1W (DOCK)
BCL2L1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 121 7 2 1
Binding ≤ 1μM 50 1 1 1
Functional ≤ 10μM 9 0 0 0

Reactome Network (2)

Reactome ID Description Species
REACT_330 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Homo sapiens
REACT_75927 The NLRP1 inflammasome Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 2
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 58

The NLRP1 inflammasome

Uniprot Swissprot Chembl Description Number Shared
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 58
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
B2CL2_HUMAN Q92843 CHEMBL4677 Apoptosis Regulator Bcl-W, Human 5 1 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
B2CL1-1-E Apoptosis Regulator Bcl-X (cluster #1 Of 2), Eukaryotic 117 7 2 1
B2CL1-2-E Apoptosis Regulator Bcl-X (cluster #2 Of 2), Eukaryotic 6 0 0 0
Uniprot Swissprot Chembl Description Number Shared
BCL2_HUMAN P10415 CHEMBL4860 Apoptosis Regulator Bcl-2, Human 58
MCL1_HUMAN Q07820 CHEMBL4361 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Human 47
B2LA1_HUMAN Q16548 CHEMBL6044 Bcl-2-related Protein A1, Human 19
MCL1_MOUSE P97287 CHEMBL5768 Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog, Mouse 4
BAD_HUMAN Q92934 CHEMBL3817 Bcl2-antagonist Of Cell Death (BAD), Human 2
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
B2CL2_HUMAN Q92843 CHEMBL4677 Apoptosis Regulator Bcl-W, Human 1
MDHC_PIG P11708 CHEMBL4048 Malate Dehydrogenase Cytoplasmic, Pig 1
MDHM_PIG P00346 CHEMBL3444 Malate Dehydrogenase Mitochondrial, Pig 1
Q0PJ46_PLAFA Q0PJ46 CHEMBL6071 Lactate Dehydrogenase, Plafa 1
Q49PX0_9POXV Q49PX0 CHEMBL1075128 N1L, 9poxv 1
Q6VVP7_PLAFA Q6VVP7 CHEMBL6072 Malate Dehydrogenase, Plafa 1
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 1

Most Common Rings