UCSF

Acetyl-CoA Carboxylase 1, Human (279 Compounds)

Swissprot:
ACACA_HUMAN
Stitch:
ACACA_HUMAN
UniProt:
Q13085
ChEMBL:
CHEMBL3351
Reactome:
REACT_147904
REACT_11153
REACT_2122
REACT_169312
REACT_1319
REACT_11082
PDB:
2YL2 (DOCK)
3COJ (DOCK)
ACACA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 279 0 0 0
Binding ≤ 1μM 200 0 0 0

Reactome Network (6)

Reactome ID Description Species
REACT_147904 Activation of gene expression by SREBF (SREBP) Homo sapiens
REACT_11153 Biotin transport and metabolism Homo sapiens
REACT_2122 ChREBP activates metabolic gene expression Homo sapiens
REACT_169312 Defective HLCS causes multiple carboxylase deficiency Homo sapiens
REACT_1319 Fatty Acyl-CoA Biosynthesis Homo sapiens
REACT_11082 Import of palmitoyl-CoA into the mitochondrial matrix Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272

Biotin transport and metabolism

Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272

ChREBP activates metabolic gene expression

Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272
ACLY_HUMAN P53396 CHEMBL3720 ATP-citrate Synthase, Human 1

Defective HLCS causes multiple carboxylase deficiency

Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272

Fatty Acyl-CoA Biosynthesis

Uniprot Swissprot Chembl Description Number Shared
ACLY_HUMAN P53396 CHEMBL3720 ATP-citrate Synthase, Human 1

Import of palmitoyl-CoA into the mitochondrial matrix

Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACACA_RAT P11497 CHEMBL2397 Acetyl-CoA Carboxylase 1, Rat 82 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ACACB_HUMAN O00763 CHEMBL4829 Acetyl-CoA Carboxylase 2, Human 272
ACACA_RAT P11497 CHEMBL2397 Acetyl-CoA Carboxylase 1, Rat 23
Q1HEC0_RAT Q1HEC0 CHEMBL5125 Acetyl-Coenzyme A Carboxylase 2, Rat 5
ACLY_HUMAN P53396 CHEMBL3720 ATP-citrate Synthase, Human 1

Most Common Rings