ZINC 12

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Names
Compounds (2)
Reactome (17)
Related By:
Pathway (15)
Organism (2)
Gene (0)
Org. Clust. (2)
ChEMBL (20)
Rings (0)

Tubulin Alpha-3 Chain, Human (2 Compounds)

Swissprot:: TBA1A_HUMAN
Stitch:: TBA1A_HUMAN
UniProt:: Q71U36
ChEMBL:: CHEMBL3661
Reactome:: REACT_16956; REACT_9509; REACT_25201; REACT_15364; REACT_15451; REACT_121399; REACT_11039; REACT_682; REACT_16967; REACT_16936; REACT_15296; REACT_15510; REACT_22365; REACT_160315; REACT_150425; REACT_150471; REACT_147867
PDB:: TUBA1A

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	2	2	2	2
Binding ≤ 1μM	0	0	0	0

Reactome ID	Description	Species
REACT_16956	Formation of tubulin folding intermediates by CCT/TriC	Homo sapiens
REACT_9509	Gap junction assembly	Homo sapiens
REACT_25201	Kinesins	Homo sapiens
REACT_15364	Loss of Nlp from mitotic centrosomes	Homo sapiens
REACT_15451	Loss of proteins required for interphase microtubule organizationÂ from the ce	Homo sapiens
REACT_121399	MHC class II antigen presentation	Homo sapiens
REACT_11039	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Homo sapiens
REACT_682	Mitotic Prometaphase	Homo sapiens
REACT_16967	Post-chaperonin tubulin folding pathway	Homo sapiens
REACT_16936	Prefoldin mediated transfer of substrate to CCT/TriC	Homo sapiens
REACT_15296	Recruitment of mitotic centrosome proteins and complexes	Homo sapiens
REACT_15510	Recruitment of NuMA to mitotic centrosomes	Homo sapiens
REACT_22365	Recycling pathway of L1	Homo sapiens
REACT_160315	Regulation of PLK1 Activity at G2/M Transition	Homo sapiens
REACT_150425	Resolution of Sister Chromatid Cohesion	Homo sapiens
REACT_150471	Separation of Sister Chromatids	Homo sapiens
REACT_147867	Translocation of GLUT4 to the plasma membrane	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Gap junction assembly

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Kinesins

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Loss of Nlp from mitotic centrosomes

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	2

Loss of proteins required for interphase microtubule organizationÂ from the ce

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	2

MHC class II antigen presentation

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Mitotic Prometaphase

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Post-chaperonin tubulin folding pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Prefoldin mediated transfer of substrate to CCT/TriC

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Recruitment of mitotic centrosome proteins and complexes

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	2

Recruitment of NuMA to mitotic centrosomes

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Recycling pathway of L1

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Regulation of PLK1 Activity at G2/M Transition

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	2

Resolution of Sister Chromatid Cohesion

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Separation of Sister Chromatids

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

Translocation of GLUT4 to the plasma membrane

Uniprot	Swissprot	Chembl	Description	Number Shared
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
TBA1A_PIG	P02550	CHEMBL3658	Tubulin Alpha Chain, Pig	46	14	10	3
TBA1A_RAT	P68370	CHEMBL4139	Tubulin Alpha-1 Chain, Rat	54	21	10	10

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
TBA1A-1-E	Tubulin Alpha-3 Chain (cluster #1 Of 3), Eukaryotic	92	25	13	8
TBA1A-2-E	Tubulin Alpha-3 Chain (cluster #2 Of 3), Eukaryotic	9	7	3	3
TBA1A-3-E	Tubulin Alpha-3 Chain (cluster #3 Of 3), Eukaryotic	1	0	1	0

Uniprot	Swissprot	Chembl	Description	Number Shared
Q862F3_BOVIN	Q862F3	CHEMBL4262	Tubulin Alpha Chain, Bovin	2
Q862L2_BOVIN	Q862L2	CHEMBL3752	Tubulin Alpha-1 Chain, Bovin	2
TBA1A_PIG	P02550	CHEMBL3658	Tubulin Alpha Chain, Pig	2
TBA1A_RAT	P68370	CHEMBL4139	Tubulin Alpha-1 Chain, Rat	2
TBA4A_HUMAN	P68366	CHEMBL2070	Tubulin Alpha-1 Chain, Human	2
TBB1_HUMAN	Q9H4B7	CHEMBL1915	Tubulin Beta-1 Chain, Human	2
TBB2B_BOVIN	Q6B856	CHEMBL3394	Tubulin Beta Chain, Bovin	2
TBB2B_RAT	Q3KRE8	CHEMBL2984	Tubulin Beta Chain, Rat	2
TBB3_HUMAN	Q13509	CHEMBL2597	Tubulin Beta-3 Chain, Human	2
TBB3_RAT	Q4QRB4	CHEMBL4569	Tubulin Beta-3 Chain, Rat	2
TBB4A_HUMAN	P04350	CHEMBL3838	Tubulin Beta-4 Chain, Human	2
TBB4B_HUMAN	P68371	CHEMBL1848	Tubulin Beta-2 Chain, Human	2
TBB5_HUMAN	P07437	CHEMBL5444	Tubulin Beta-5 Chain, Human	2
TBB8_HUMAN	Q3ZCM7	CHEMBL4024	Tubulin Beta-8 Chain, Human	2
TBB_PIG	P02554	CHEMBL2788	Tubulin Beta Chain, Pig	2
TBG1_RAT	P83888	CHEMBL2881	Tubulin Gamma-1 Chain, Rat	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	1
O46399_SHEEP	O46399	CHEMBL3462	Beta Tubulin, Sheep	1
Q9MZB0_SHEEP	Q9MZB0	CHEMBL4099	Tubulin Alpha-1 Chain, Sheep	1
VE2_HPV1A	P03118	CHEMBL5822	Regulatory Protein E2, Hpv1a	1

Synonyms
Compounds (2)
Related By:
Pathway (15)
Organism (2)
Gene (0)
ChEMBL (20)
Org. Clust. (2)
Rings (0)

ZINC 12

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Tubulin Alpha-3 Chain, Human (2 Compounds)

Compound Summary

Reactome Network (17)

Related Targets

Formation of tubulin folding intermediates by CCT/TriC

Gap junction assembly

Kinesins

Loss of Nlp from mitotic centrosomes

Loss of proteins required for interphase microtubule organizationÂ from the ce

MHC class II antigen presentation

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Mitotic Prometaphase

Post-chaperonin tubulin folding pathway

Prefoldin mediated transfer of substrate to CCT/TriC

Recruitment of mitotic centrosome proteins and complexes

Recruitment of NuMA to mitotic centrosomes

Recycling pathway of L1

Regulation of PLK1 Activity at G2/M Transition

Resolution of Sister Chromatid Cohesion

Separation of Sister Chromatids

Translocation of GLUT4 to the plasma membrane

By Organism (2)

Clustered By Gene (0)

Clustered By Organism (2)

By Shared ChEMBL Annotated Substances