UCSF

Tubulin Beta-4 Chain, Human (26 Compounds)

Swissprot:
TBB4A_HUMAN
Stitch:
TBB4A_HUMAN
UniProt:
P04350
ChEMBL:
CHEMBL3838
Reactome:
REACT_16956
REACT_9509
REACT_25201
REACT_15364
REACT_15451
REACT_121399
REACT_11039
REACT_682
REACT_16967
REACT_16936
REACT_15296
REACT_15510
REACT_22365
REACT_160315
REACT_150425
REACT_150471
REACT_147867

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 26 9 4 2
Binding ≤ 1μM 7 5 2 2
Functional ≤ 10μM 115 21 7 2

Reactome Network (17)

Reactome ID Description Species
REACT_16956 Formation of tubulin folding intermediates by CCT/TriC Homo sapiens
REACT_9509 Gap junction assembly Homo sapiens
REACT_25201 Kinesins Homo sapiens
REACT_15364 Loss of Nlp from mitotic centrosomes Homo sapiens
REACT_15451 Loss of proteins required for interphase microtubule organization from the ce Homo sapiens
REACT_121399 MHC class II antigen presentation Homo sapiens
REACT_11039 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Homo sapiens
REACT_682 Mitotic Prometaphase Homo sapiens
REACT_16967 Post-chaperonin tubulin folding pathway Homo sapiens
REACT_16936 Prefoldin mediated transfer of substrate to CCT/TriC Homo sapiens
REACT_15296 Recruitment of mitotic centrosome proteins and complexes Homo sapiens
REACT_15510 Recruitment of NuMA to mitotic centrosomes Homo sapiens
REACT_22365 Recycling pathway of L1 Homo sapiens
REACT_160315 Regulation of PLK1 Activity at G2/M Transition Homo sapiens
REACT_150425 Resolution of Sister Chromatid Cohesion Homo sapiens
REACT_150471 Separation of Sister Chromatids Homo sapiens
REACT_147867 Translocation of GLUT4 to the plasma membrane Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Gap junction assembly

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Kinesins

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Loss of Nlp from mitotic centrosomes

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 45

Loss of proteins required for interphase microtubule organization from the ce

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 45

MHC class II antigen presentation

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Mitotic Prometaphase

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Post-chaperonin tubulin folding pathway

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Prefoldin mediated transfer of substrate to CCT/TriC

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Recruitment of mitotic centrosome proteins and complexes

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 45

Recruitment of NuMA to mitotic centrosomes

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Recycling pathway of L1

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Regulation of PLK1 Activity at G2/M Transition

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 45

Resolution of Sister Chromatid Cohesion

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Separation of Sister Chromatids

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Translocation of GLUT4 to the plasma membrane

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 138
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 138
TBB8_HUMAN Q3ZCM7 CHEMBL4024 Tubulin Beta-8 Chain, Human 138
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 130
TBB5_HUMAN P07437 CHEMBL5444 Tubulin Beta-5 Chain, Human 45
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 34
Z80612 Z80612 CHEMBL612818 2008 (Ovarian Carcinoma Cells) 33
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 20
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 18
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 17
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 16
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 16
Z81001 Z81001 CHEMBL614787 TSGH 9201 (Gastric Carcinoma Cells) 15
Z80071 Z80071 CHEMBL614028 CEM-0 (T-cell Leukemia) 11
Z80136 Z80136 CHEMBL614297 FM3A (Breast Carcinoma Cells) 11
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 11
TBB2B_BOVIN Q6B856 CHEMBL3394 Tubulin Beta Chain, Bovin 8
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 8
Q862F3_BOVIN Q862F3 CHEMBL4262 Tubulin Alpha Chain, Bovin 7
Q862L2_BOVIN Q862L2 CHEMBL3752 Tubulin Alpha-1 Chain, Bovin 7
TBA1A_PIG P02550 CHEMBL3658 Tubulin Alpha Chain, Pig 7
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 6
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 5
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 5
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 5
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 4
Z80053 Z80053 CHEMBL612566 CA46 (Burkitts Lymphoma Cells) 4
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 4
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 4
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 4
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 4
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
Z50591 Z50591 CHEMBL613489 Bos Taurus 3
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 3
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 3
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBB2B_RAT Q3KRE8 CHEMBL2984 Tubulin Beta Chain, Rat 2
TBB3_RAT Q4QRB4 CHEMBL4569 Tubulin Beta-3 Chain, Rat 2
TBB_PIG P02554 CHEMBL2788 Tubulin Beta Chain, Pig 2
TBG1_RAT P83888 CHEMBL2881 Tubulin Gamma-1 Chain, Rat 2
Z103203 Z103203 CHEMBL1075388 A375 2
Z103205 Z103205 CHEMBL1075390 A431 2
Z80002 Z80002 CHEMBL614075 1A9 (Ovarian Adenocarcinoma Cells) 2
Z80025 Z80025 CHEMBL614519 ACHN (Renal Adenocarcinoma Cells) 2
Z80035 Z80035 CHEMBL381 B16 (Melanoma Cells) 2
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 2
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 2
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 2
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 2
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 2
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 2
Z80466 Z80466 CHEMBL614907 SF268 2
Z80526 Z80526 CHEMBL612544 SW480 (Colon Adenocarcinoma Cells) 2
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 2
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 2
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 2
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 2
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 2
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 1
O46399_SHEEP O46399 CHEMBL3462 Beta Tubulin, Sheep 1
Q25270_LEIDO Q25270 CHEMBL3186 Beta Tubulin, Leido 1
Q9MZB0_SHEEP Q9MZB0 CHEMBL4099 Tubulin Alpha-1 Chain, Sheep 1
VE2_HPV1A P03118 CHEMBL5822 Regulatory Protein E2, Hpv1a 1
Z100495 Z100495 CHEMBL613880 BMEC (Brain Microvessel Endothelial Cells) 1
Z100742 Z100742 CHEMBL613300 MeWo (Melanoma Cells) 1
Z101682 Z101682 CHEMBL613915 BK Polyomavirus 1
Z103208 Z103208 CHEMBL1075393 AU565 1
Z103407 Z103407 CHEMBL1075592 SW1990 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z80013 Z80013 CHEMBL614513 A10 1
Z80024 Z80024 CHEMBL614518 A9 (Fibroblast Cells) 1
Z80063 Z80063 CHEMBL614027 CCRF S-180 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 1
Z80096 Z80096 CHEMBL614559 CHO-TAX 5-6 1
Z80097 Z80097 CHEMBL614560 CHO-VV 3-2 1
Z80099 Z80099 CHEMBL614561 COLO 205 (Colon Adenocarcinoma Cells) 1
Z80121 Z80121 CHEMBL614286 DMS-79 (Small Cell Lung Carcinoma Cells) 1
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80229 Z80229 CHEMBL614326 MCF7-DOX (Breast Carcinoma Cells) 1
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 1
Z80254 Z80254 CHEMBL614343 MES-SA (Uterine Sarcoma Cells) 1
Z80255 Z80255 CHEMBL613827 MES-SA/DxS (Uterine Sarcoma Cells) 1
Z80284 Z80284 CHEMBL614176 MOLT-3 (T-lymphoblastic Leukemia Cells) 1
Z80353 Z80353 CHEMBL614212 OVCAR 1
Z80354 Z80354 CHEMBL614213 OVCAR-3 (Ovarian Adenocarcinoma Cells) 1
Z80414 Z80414 CHEMBL614628 Raji (B-lymphoblastic Cells) 1
Z80427 Z80427 CHEMBL614879 RKO (Colon Carcinoma) 1
Z80471 Z80471 CHEMBL614910 SH-SY5 (Bone Marrow Neuroblastoma Cells) 1
Z80472 Z80472 CHEMBL612542 SiHa (Cervical Squamous Cell Carcinoma) 1
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80555 Z80555 CHEMBL615018 TSGH 1
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 1
Z80583 Z80583 CHEMBL391 Vero (Kidney Cells) 1
Z80608 Z80608 CHEMBL614393 ZR-75-1 (Breast Carcinoma Cells) 1
Z80697 Z80697 CHEMBL614279 Bel-7402 (Hepatoma Cells) 1
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 1
Z80720 Z80720 CHEMBL614365 Burkitts Lymphoma Cells 1
Z80792 Z80792 CHEMBL614466 Colon 26 (Colon Adenocarcinoma Cells) 1
Z80798 Z80798 CHEMBL614470 CPT30 Cell Line 1
Z80819 Z80819 CHEMBL614484 J774.2 1
Z80847 Z80847 CHEMBL612250 FaDu (Pharyngeal Carcinoma Cells) 1
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 1
Z80900 Z80900 CHEMBL614807 HA22T Cell Line 1
Z80967 Z80967 CHEMBL614831 Hone-1 Cell Line 1
Z81054 Z81054 CHEMBL613977 SF-268 (Glioblastoma Cells) 1
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 1
Z81065 Z81065 CHEMBL613984 IGROV-1 (Ovarian Adenocarcinoma Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1
Z81233 Z81233 CHEMBL614117 M21 (Melanoma Cells) 1
Z81244 Z81244 CHEMBL614123 J774 (Macrophage Cells) 1
Z81281 Z81281 CHEMBL614997 NCI-H23 (Non-small Cell Lung Carcinoma Cells) 1
Z81283 Z81283 CHEMBL614387 NCI-H522 (Non-small Cell Lung Carcinoma Cells) 1