UCSF

Tubulin Beta-5 Chain, Human (15 Compounds)

Swissprot:
TBB5_HUMAN
Stitch:
TBB5_HUMAN
UniProt:
P07437
ChEMBL:
CHEMBL5444
Reactome:
REACT_15364
REACT_15451
REACT_15296
REACT_160315
PDB:
TUBB

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 15 3 2 2
Binding ≤ 1μM 4 2 1 1
Functional ≤ 10μM 31 4 3 1

Reactome Network (4)

Reactome ID Description Species
REACT_15364 Loss of Nlp from mitotic centrosomes Homo sapiens
REACT_15451 Loss of proteins required for interphase microtubule organization from the ce Homo sapiens
REACT_15296 Recruitment of mitotic centrosome proteins and complexes Homo sapiens
REACT_160315 Regulation of PLK1 Activity at G2/M Transition Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 45
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 45

Loss of proteins required for interphase microtubule organization from the ce

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 45
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 45

Recruitment of mitotic centrosome proteins and complexes

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 45
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 45

Regulation of PLK1 Activity at G2/M Transition

Uniprot Swissprot Chembl Description Number Shared
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 45
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 45
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 133 24 8 3
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 26 9 4 2
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 26 9 4 2
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 26 9 4 2
TBB8_HUMAN Q3ZCM7 CHEMBL4024 Tubulin Beta-8 Chain, Human 26 9 4 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
TBB3_HUMAN Q13509 CHEMBL2597 Tubulin Beta-3 Chain, Human 45
TBB4A_HUMAN P04350 CHEMBL3838 Tubulin Beta-4 Chain, Human 45
TBB4B_HUMAN P68371 CHEMBL1848 Tubulin Beta-2 Chain, Human 45
TBB8_HUMAN Q3ZCM7 CHEMBL4024 Tubulin Beta-8 Chain, Human 45
TBB1_HUMAN Q9H4B7 CHEMBL1915 Tubulin Beta-1 Chain, Human 37
Z80193 Z80193 CHEMBL386 L1210 (Lymphocytic Leukemia Cells) 17
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 16
Z80269 Z80269 CHEMBL614354 MKN-45 (Gastric Adenocarcinoma Cells) 16
Z81024 Z81024 CHEMBL396 NCI-H460 (Non-small Cell Lung Carcinoma) 16
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 16
Z81001 Z81001 CHEMBL614787 TSGH 9201 (Gastric Carcinoma Cells) 15
Z80071 Z80071 CHEMBL614028 CEM-0 (T-cell Leukemia) 11
Z80136 Z80136 CHEMBL614297 FM3A (Breast Carcinoma Cells) 11
Z80285 Z80285 CHEMBL614177 MOLT-4 (Acute T-lymphoblastic Leukemia Cells) 11
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 7
Q862F3_BOVIN Q862F3 CHEMBL4262 Tubulin Alpha Chain, Bovin 5
Q862L2_BOVIN Q862L2 CHEMBL3752 Tubulin Alpha-1 Chain, Bovin 5
TBB2B_BOVIN Q6B856 CHEMBL3394 Tubulin Beta Chain, Bovin 5
TBA1A_PIG P02550 CHEMBL3658 Tubulin Alpha Chain, Pig 4
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 4
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 4
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 3
TBA4A_HUMAN P68366 CHEMBL2070 Tubulin Alpha-1 Chain, Human 3
Z50591 Z50591 CHEMBL613489 Bos Taurus 3
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 3
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 3
Z81335 Z81335 CHEMBL612263 HCT-15 (Colon Adenocarcinoma Cells) 3
TBA1A_HUMAN Q71U36 CHEMBL3661 Tubulin Alpha-3 Chain, Human 2
TBB2B_RAT Q3KRE8 CHEMBL2984 Tubulin Beta Chain, Rat 2
TBB3_RAT Q4QRB4 CHEMBL4569 Tubulin Beta-3 Chain, Rat 2
TBB_PIG P02554 CHEMBL2788 Tubulin Beta Chain, Pig 2
TBG1_RAT P83888 CHEMBL2881 Tubulin Gamma-1 Chain, Rat 2
Z103203 Z103203 CHEMBL1075388 A375 2
Z103205 Z103205 CHEMBL1075390 A431 2
Z80002 Z80002 CHEMBL614075 1A9 (Ovarian Adenocarcinoma Cells) 2
Z80025 Z80025 CHEMBL614519 ACHN (Renal Adenocarcinoma Cells) 2
Z80035 Z80035 CHEMBL381 B16 (Melanoma Cells) 2
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 2
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 2
Z80211 Z80211 CHEMBL614721 LoVo (Colon Adenocarcinoma Cells) 2
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 2
Z80390 Z80390 CHEMBL390 PC-3 (Prostate Carcinoma Cells) 2
Z80493 Z80493 CHEMBL614925 SK-OV-3 (Ovarian Carcinoma Cells) 2
Z80526 Z80526 CHEMBL612544 SW480 (Colon Adenocarcinoma Cells) 2
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 2
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 2
Z80852 Z80852 CHEMBL614069 A-431 (Epidermoid Carcinoma Cells) 2
Z80874 Z80874 CHEMBL393 CEM (T-cell Leukemia) 2
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 2
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 2
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 2
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 2
Z81331 Z81331 CHEMBL612262 SW-620 (Colon Adenocarcinoma Cells) 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 1
O46399_SHEEP O46399 CHEMBL3462 Beta Tubulin, Sheep 1
Q25270_LEIDO Q25270 CHEMBL3186 Beta Tubulin, Leido 1
Q9MZB0_SHEEP Q9MZB0 CHEMBL4099 Tubulin Alpha-1 Chain, Sheep 1
VE2_HPV1A P03118 CHEMBL5822 Regulatory Protein E2, Hpv1a 1
Z100495 Z100495 CHEMBL613880 BMEC (Brain Microvessel Endothelial Cells) 1
Z100742 Z100742 CHEMBL613300 MeWo (Melanoma Cells) 1
Z101682 Z101682 CHEMBL613915 BK Polyomavirus 1
Z103208 Z103208 CHEMBL1075393 AU565 1
Z103407 Z103407 CHEMBL1075592 SW1990 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 1
Z80013 Z80013 CHEMBL614513 A10 1
Z80024 Z80024 CHEMBL614518 A9 (Fibroblast Cells) 1
Z80054 Z80054 CHEMBL614058 Caco-2 (Colon Adenocarcinoma Cells) 1
Z80064 Z80064 CHEMBL382 CCRF-CEM (T-cell Leukemia) 1
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 1
Z80096 Z80096 CHEMBL614559 CHO-TAX 5-6 1
Z80097 Z80097 CHEMBL614560 CHO-VV 3-2 1
Z80099 Z80099 CHEMBL614561 COLO 205 (Colon Adenocarcinoma Cells) 1
Z80121 Z80121 CHEMBL614286 DMS-79 (Small Cell Lung Carcinoma Cells) 1
Z80164 Z80164 CHEMBL614580 HT-1080 (Fibrosarcoma Cells) 1
Z80229 Z80229 CHEMBL614326 MCF7-DOX (Breast Carcinoma Cells) 1
Z80244 Z80244 CHEMBL614335 MDA-MB-468 (Breast Adenocarcinoma) 1
Z80254 Z80254 CHEMBL614343 MES-SA (Uterine Sarcoma Cells) 1
Z80255 Z80255 CHEMBL613827 MES-SA/DxS (Uterine Sarcoma Cells) 1
Z80284 Z80284 CHEMBL614176 MOLT-3 (T-lymphoblastic Leukemia Cells) 1
Z80353 Z80353 CHEMBL614212 OVCAR 1
Z80354 Z80354 CHEMBL614213 OVCAR-3 (Ovarian Adenocarcinoma Cells) 1
Z80414 Z80414 CHEMBL614628 Raji (B-lymphoblastic Cells) 1
Z80427 Z80427 CHEMBL614879 RKO (Colon Carcinoma) 1
Z80466 Z80466 CHEMBL614907 SF268 1
Z80471 Z80471 CHEMBL614910 SH-SY5 (Bone Marrow Neuroblastoma Cells) 1
Z80475 Z80475 CHEMBL613834 SK-BR-3 (Breast Adenocarcinoma) 1
Z80485 Z80485 CHEMBL614919 SK-MEL-28 (Melanoma Cells) 1
Z80555 Z80555 CHEMBL615018 TSGH 1
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 1
Z80583 Z80583 CHEMBL391 Vero (Kidney Cells) 1
Z80608 Z80608 CHEMBL614393 ZR-75-1 (Breast Carcinoma Cells) 1
Z80697 Z80697 CHEMBL614279 Bel-7402 (Hepatoma Cells) 1
Z80712 Z80712 CHEMBL614361 T47D (Breast Carcinoma Cells) 1
Z80720 Z80720 CHEMBL614365 Burkitts Lymphoma Cells 1
Z80792 Z80792 CHEMBL614466 Colon 26 (Colon Adenocarcinoma Cells) 1
Z80798 Z80798 CHEMBL614470 CPT30 Cell Line 1
Z80819 Z80819 CHEMBL614484 J774.2 1
Z80847 Z80847 CHEMBL612250 FaDu (Pharyngeal Carcinoma Cells) 1
Z80896 Z80896 CHEMBL614805 NCI-H69 (Small Cell Lung Carcinoma Cells) 1
Z80900 Z80900 CHEMBL614807 HA22T Cell Line 1
Z80967 Z80967 CHEMBL614831 Hone-1 Cell Line 1
Z81034 Z81034 CHEMBL614004 A2780 (Ovarian Carcinoma Cells) 1
Z81054 Z81054 CHEMBL613977 SF-268 (Glioblastoma Cells) 1
Z81057 Z81057 CHEMBL613979 HUVEC (Umbilical Vein Endothelial Cells) 1
Z81065 Z81065 CHEMBL613984 IGROV-1 (Ovarian Adenocarcinoma Cells) 1
Z81170 Z81170 CHEMBL612518 LNCaP (Prostate Carcinoma) 1
Z81233 Z81233 CHEMBL614117 M21 (Melanoma Cells) 1
Z81244 Z81244 CHEMBL614123 J774 (Macrophage Cells) 1
Z81281 Z81281 CHEMBL614997 NCI-H23 (Non-small Cell Lung Carcinoma Cells) 1
Z81283 Z81283 CHEMBL614387 NCI-H522 (Non-small Cell Lung Carcinoma Cells) 1