UCSF

Phosphodiesterase 4B, Human (1,476 Compounds)

Swissprot:
PDE4B_HUMAN
Stitch:
PDE4B_HUMAN
UniProt:
Q07343
ChEMBL:
CHEMBL275
Reactome:
REACT_15334
REACT_19327
PDB:
1F0J (DOCK)
1JP1 (DOCK)
1JP2 (DOCK)
1RO6 (DOCK)
1RO9 (DOCK)
1ROR (DOCK)
1TB5 (DOCK)
1XLX (DOCK)
1XLZ (DOCK)
1XM4 (DOCK)
1XM6 (DOCK)
1XMU (DOCK)
1XMY (DOCK)
1XN0 (DOCK)
1XOS (DOCK)
1XOT (DOCK)
1Y2H (DOCK)
1Y2J (DOCK)
2CHM (DOCK)
2QYL (DOCK)
3D3P (DOCK)
3FRG (DOCK)
3G45 (DOCK)
3GWT (DOCK)
3HC8 (DOCK)
3HDZ (DOCK)
3HMV (DOCK)
3KKT (DOCK)
3LY2 (DOCK)
3O0J (DOCK)
3O56 (DOCK)
3O57 (DOCK)
PDE4B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,476 81 25 32
Binding ≤ 1μM 1,071 40 14 20
Functional ≤ 10μM 112 2 2 2

Reactome Network (2)

Reactome ID Description Species
REACT_15334 DARPP-32 events Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1180
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1097
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1248

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 19
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 18
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 30
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 30
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 5
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 110
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 107
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1180
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1097
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1248
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 6
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 5
PDE8A_HUMAN O60658 CHEMBL4640 Phosphodiesterase 8A, Human 1
PDE8B_HUMAN O95263 CHEMBL4408 Phosphodiesterase 8B, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 250 12 14 11

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PDE4B-1-E Phosphodiesterase 4B (cluster #1 Of 2), Eukaryotic 1,270 60 20 19
PDE4B-2-E Phosphodiesterase 4B (cluster #2 Of 2), Eukaryotic 310 27 10 15
Uniprot Swissprot Chembl Description Number Shared
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1248
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1180
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1097
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 154
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 153
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 153
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 131
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 110
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 107
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 51
Z80566 Z80566 CHEMBL612794 U-937 (Histiocytic Lymphoma Cells) 51
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 42
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 30
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 30
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 30
PDE4A_MOUSE O89084 CHEMBL2698 Phosphodiesterase 4A, Mouse 26
PDE4C_MOUSE Q3UEI1 CHEMBL2550 Phosphodiesterase 4C, Mouse 26
PDE4D_MOUSE Q01063 CHEMBL3846 Phosphodiesterase 4D, Mouse 26
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 26
Q8VBU5_MOUSE Q8VBU5 CHEMBL2272 Phosphodiesterase 4B, Mouse 26
Z100081 Z100081 CHEMBL613107 PBMC (Peripheral Blood Mononuclear Cells) 24
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 19
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 18
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 18
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 18
MMP2_HUMAN P08253 CHEMBL333 Matrix Metalloproteinase-2, Human 16
MMP3_HUMAN P08254 CHEMBL283 Matrix Metalloproteinase 3, Human 16
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 15
MMP1_HUMAN P03956 CHEMBL332 Matrix Metalloproteinase-1, Human 14
PDE5A_BOVIN Q28156 CHEMBL3478 Phosphodiesterase 5A, Bovin 14
Z50512 Z50512 CHEMBL369 Cavia Porcellus 14
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 13
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 11
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 8
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 8
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 8
E1BN64_BOVIN E1BN64 CHEMBL5129 Phosphodiesterase 3B, Bovin 7
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 7
Q9EPR9_RAT Q9EPR9 CHEMBL2740 Phosphodiesterase 1A, Rat 7
PDE2A_BOVIN P14099 CHEMBL3477 Phosphodiesterase 2A, Bovin 6
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 6
Z100709 Z100709 CHEMBL613821 Squirrel Monkey 6
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 5
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 5
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 5
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 4
CNCG_HUMAN Q13956 CHEMBL2341 Phosphodiesterase 6H, Human 4
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 4
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 4
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 4
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 4
CNCG_BOVIN P22571 CHEMBL4606 Phosphodiesterase 6H, Bovin 3
CNRG_BOVIN P04972 CHEMBL5111 Phosphodiesterase 6G, Bovin 3
PDE6A_BOVIN P11541 CHEMBL3741 Phosphodiesterase 6A, Bovin 3
PDE6B_BOVIN P23439 CHEMBL2713 Phosphodiesterase 6B, Bovin 3
PDE6C_BOVIN P16586 CHEMBL3479 Phosphodiesterase 6C, Bovin 3
PDE6D_BOVIN Q95142 CHEMBL5110 Phosphodiesterase 6D, Bovin 3
PDE7A_RAT O08593 CHEMBL3450 Phosphodiesterase 7A, Rat 3
Z100489 Z100489 CHEMBL614636 Eosinophils (Eosinophils) 3
Z50587 Z50587 CHEMBL372 Homo Sapiens 3
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 2
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 2
Q9XSW7_PIG Q9XSW7 CHEMBL3061 Phosphodiesterase 3A, Pig 2
TNFA_HUMAN P01375 CHEMBL1825 TNF-alpha, Human 2
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 2
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 1
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 1
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
BMP1_HUMAN P13497 CHEMBL3898 Bone Morphogenetic Protein 1, Human 1
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 1
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 1
PDE3A_RAT Q62865 CHEMBL2711 Phosphodiesterase 3A, Rat 1
PDE3B_RAT Q63085 CHEMBL3580 Phosphodiesterase 3B, Rat 1
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 1
PDE8A_HUMAN O60658 CHEMBL4640 Phosphodiesterase 8A, Human 1
PDE8B_HUMAN O95263 CHEMBL4408 Phosphodiesterase 8B, Human 1
Q8VIE4_RAT Q8VIE4 CHEMBL3386 Phosphodiesterase 7B, Rat 1
S29A1_HUMAN Q99808 CHEMBL1997 Equilibrative Nucleoside Transporter 1, Human 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
Z102191 Z102191 CHEMBL613397 Blood 1
Z102213 Z102213 CHEMBL613416 Blood 1

Most Common Rings