UCSF

CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat (40 Compounds)

Swissprot:
PDE10_RAT
Stitch:
PDE10_RAT
UniProt:
Q9QYJ6
ChEMBL:
CHEMBL6140
Reactome:
REACT_250690
REACT_246814
PDB:
2O8H (DOCK)
2OVV (DOCK)
2OVY (DOCK)
3HQW (DOCK)
3HQY (DOCK)
3HQZ (DOCK)
3HR1 (DOCK)
3LXG (DOCK)
3QPN (DOCK)
3QPO (DOCK)
3QPP (DOCK)
Pde10a

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 40 2 1 4
Binding ≤ 1μM 33 2 1 4

Reactome Network (2)

Reactome ID Description Species
REACT_250690 cGMP effects Rattus norvegicus
REACT_246814 G alpha (s) signalling events Rattus norvegicus
Uniprot Swissprot Chembl Description Number Shared
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 1

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 1
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 224 22 5 7
PDE10_MOUSE Q8CA95 CHEMBL1795126 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Mouse 45 3 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 35 7 3 3
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 20 6 2 2
PDE2A_RAT Q01062 CHEMBL4650 Phosphodiesterase 2A, Rat 2 0 0 0
PDE3A_RAT Q62865 CHEMBL2711 Phosphodiesterase 3A, Rat 4 1 4 1
PDE3B_RAT Q63085 CHEMBL3580 Phosphodiesterase 3B, Rat 4 1 4 1
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 232 12 14 11
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 250 12 14 11
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 196 12 12 10
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 233 12 14 11
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 45 2 7 2
PDE7A_RAT O08593 CHEMBL3450 Phosphodiesterase 7A, Rat 16 0 0 0

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 5
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 2
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 1
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 1
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 1
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 1
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 1
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 1
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 1
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 1
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 1
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 1
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 1
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 1
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 1
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 1
Q9XSW7_PIG Q9XSW7 CHEMBL3061 Phosphodiesterase 3A, Pig 1

Most Common Rings