UCSF

Adenosine A1 Receptor, Human (2,632 Compounds)

Swissprot:
AA1R_HUMAN
Stitch:
AA1R_HUMAN
UniProt:
P30542
ChEMBL:
CHEMBL226
Reactome:
REACT_18288
REACT_19231
PDB:
ADORA1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,632 98 19 17
Binding ≤ 1μM 1,962 68 9 12
Functional ≤ 10μM 220 11 3 2

Reactome Network (2)

Reactome ID Description Species
REACT_18288 Adenosine P1 receptors Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1777
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 842
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1241

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 3
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1241
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 4
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 6
P2Y12_HUMAN Q9H244 CHEMBL2001 Purinergic Receptor P2Y12, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 714 56 10 8
AA1R_CHICK P49892 CHEMBL2114 Adenosine A1 Receptor, Chick 24 3 0 1
AA1R_MOUSE Q60612 CHEMBL3688 Adenosine A1 Receptor, Mouse 25 3 1 2
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 3,254 205 59 36

Clustered By Gene (0)

Clustered By Organism (3)

Code Description Substances Purchasable Natural In Man
AA1R-1-E Adenosine A1 Receptor (cluster #1 Of 4), Eukaryotic 101 19 9 5
AA1R-2-E Adenosine A1 Receptor (cluster #2 Of 4), Eukaryotic 6,188 278 58 40
AA1R-3-E Adenosine A1 Receptor (cluster #3 Of 4), Eukaryotic 12 6 4 1
AA1R-4-E Adenosine A1 Receptor (cluster #4 Of 4), Eukaryotic 4 0 0 0
Uniprot Swissprot Chembl Description Number Shared
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 1766
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1239
AA2BR_HUMAN P29275 CHEMBL255 Adenosine A2b Receptor, Human 692
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 303
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 209
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 160
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 122
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 62
AA1R_MOUSE Q60612 CHEMBL3688 Adenosine A1 Receptor, Mouse 25
AA3R_MOUSE Q61618 CHEMBL1075269 Adenosine Receptor A3, Mouse 22
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 16
Q4VQ11_PIG Q4VQ11 CHEMBL1075029 A1 Adenosine Receptor, Pig 12
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 11
Z50512 Z50512 CHEMBL369 Cavia Porcellus 9
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 7
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 7
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 7
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 7
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 7
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 7
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 7
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 7
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 7
GBRD_HUMAN O14764 CHEMBL3591 GABA Receptor Delta Subunit, Human 7
GBRE_HUMAN P78334 CHEMBL4635 GABA Receptor Epsilon Subunit, Human 7
GBRG1_HUMAN Q8N1C3 CHEMBL4044 GABA Receptor Gamma-1 Subunit, Human 7
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 7
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 7
GBRP_HUMAN O00591 CHEMBL3506 GABA Receptor Pi Subunit, Human 7
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 7
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 7
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 6
AA2AR_MOUSE Q60613 CHEMBL2115 Adenosine A2a Receptor, Mouse 5
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 5
GBRA1_BOVIN P08219 CHEMBL3627 GABA Receptor Alpha-1 Subunit, Bovin 5
GBRA2_BOVIN P10063 CHEMBL2321 GABA Receptor Alpha-2 Subunit, Bovin 5
GBRA3_BOVIN P10064 CHEMBL3628 GABA Receptor Alpha-3 Subunit, Bovin 5
GBRA4_BOVIN P20237 CHEMBL3140 GABA Receptor Alpha-4 Subunit, Bovin 5
GBRB1_BOVIN P08220 CHEMBL2848 GABA Receptor Beta-1 Subunit, Bovin 5
GBRG2_BOVIN P22300 CHEMBL5138 GABA Receptor Gamma-2 Subunit, Bovin 5
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 4
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 4
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 4
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 4
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 4
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 4
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 4
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 4
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 4
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 4
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 3
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 3
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 3
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 3
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 3
GBRA1_RAT P62813 CHEMBL343 GABA Receptor Alpha-1 Subunit, Rat 3
GBRA2_RAT P23576 CHEMBL341 GABA Receptor Alpha-2 Subunit, Rat 3
GBRA5_RAT P19969 CHEMBL300 GABA Receptor Alpha-5 Subunit, Rat 3
GBRB2_RAT P63138 CHEMBL295 GABA Receptor Beta-2 Subunit, Rat 3
GBRB3_RAT P63079 CHEMBL316 GABA Receptor Beta-3 Subunit, Rat 3
GBRG2_RAT P18508 CHEMBL297 GABA Receptor Gamma-2 Subunit, Rat 3
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 3
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 3
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 3
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
AA1R_CHICK P49892 CHEMBL2114 Adenosine A1 Receptor, Chick 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 2
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 2
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
AA2BR_MOUSE Q60614 CHEMBL2237 Adenosine A2b Receptor, Mouse 1
AA3R_BOVIN Q0VC81 CHEMBL1287626 Adenosine Receptor A3, Bovin 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY3_HUMAN O60266 CHEMBL3164 Adenylate Cyclase Type III, Human 1
ADCY5_HUMAN O95622 CHEMBL3189 Adenylate Cyclase Type V, Human 1
ADCY6_HUMAN O43306 CHEMBL3221 Adenylate Cyclase Type VI, Human 1
ADCY7_HUMAN P51828 CHEMBL4922 Adenylate Cyclase Type VII, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
ADCY9_HUMAN O60503 CHEMBL2655 Adenylate Cyclase Type IX, Human 1
CNCG_HUMAN Q13956 CHEMBL2341 Phosphodiesterase 6H, Human 1
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 1
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OXGR1_RAT Q6Y1R5 CHEMBL2325 G Protein-coupled Receptor 80, Rat 1
P2Y12_HUMAN Q9H244 CHEMBL2001 Purinergic Receptor P2Y12, Human 1
P4K2A_HUMAN Q9BTU6 CHEMBL2251 PI4-kinase Type II, Human 1
P4K2B_HUMAN Q8TCG2 CHEMBL3220 PI4-kinase Type II Beta, Human 1
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 1
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 1
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 1
PDE1B_HUMAN Q01064 CHEMBL4425 Phosphodiesterase 1B, Human 1
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 1
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 1
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 1
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 1
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 1
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 1
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 1
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 1
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 1
PI4KA_HUMAN P42356 CHEMBL3667 PI4-kinase Alpha Subunit, Human 1
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 1
S29A1_HUMAN Q99808 CHEMBL1997 Equilibrative Nucleoside Transporter 1, Human 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
TSPOB_HUMAN B1AH88 CHEMBL5139 Peripheral-type Benzodiazepine Receptor, Human 1
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 1
Z100273 Z100273 CHEMBL612413 P3 Purinoceptor 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50588 Z50588 CHEMBL373 Canis Familiaris 1
Z80945 Z80945 CHEMBL614735 HEp-2 (Laryngeal Carcinoma Cells) 1

Most Common Rings