UCSF

GABA Receptor Alpha-4 Subunit, Human (328 Compounds)

Swissprot:
GBRA4_HUMAN
Stitch:
GBRA4_HUMAN
UniProt:
P48169
ChEMBL:
CHEMBL2472
Reactome:
REACT_24987
REACT_25387
PDB:
GABRA4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 328 41 24 12
Binding ≤ 1μM 273 27 19 10
Functional ≤ 10μM 17 6 3 2

Reactome Network (2)

Reactome ID Description Species
REACT_24987 GABA A receptor activation Homo sapiens
REACT_25387 Ligand-gated ion channel transport Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 331
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 328
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 329
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 329
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 324
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 242
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 243
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 273
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 273
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 241
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 166

Ligand-gated ion channel transport

Uniprot Swissprot Chembl Description Number Shared
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 331
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 328
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 329
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 329
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 324
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 242
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 243
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 273
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 273
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 241
GBRR1_HUMAN P24046 CHEMBL3561 GABA Receptor Rho-1 Subunit, Human 3
GBRR2_HUMAN P28476 CHEMBL2375 GABA Receptor Rho-2 Subunit, Human 3
GBRR3_HUMAN A8MPY1 CHEMBL2394 GABA Receptor Rho-3 Subunit, Human 2
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 166
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GBRA4_BOVIN P20237 CHEMBL3140 GABA Receptor Alpha-4 Subunit, Bovin 302 43 17 5
GBRA4_MOUSE Q9D6F4 CHEMBL4182 GABA Receptor Alpha-4 Subunit, Mouse 37 3 2 2
GBRA4_RAT P28471 CHEMBL292 GABA Receptor Alpha-4 Subunit, Rat 147 11 11 7
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 959 77 35 22
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 835 75 35 22
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 957 72 33 20
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 957 69 31 18
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 391 48 26 13

Clustered By Gene (0)

Clustered By Organism (6)

Code Description Substances Purchasable Natural In Man
GBRA4-1-E GABA Receptor Alpha-4 Subunit (cluster #1 Of 7), Eukaryotic 723 74 38 15
GBRA4-2-E GABA Receptor Alpha-4 Subunit (cluster #2 Of 7), Eukaryotic 20 2 2 0
GBRA4-3-E GABA Receptor Alpha-4 Subunit (cluster #3 Of 7), Eukaryotic 30 1 0 0
GBRA4-4-E GABA Receptor Alpha-4 Subunit (cluster #4 Of 7), Eukaryotic 24 4 4 3
GBRA4-5-E GABA Receptor Alpha-4 Subunit (cluster #5 Of 7), Eukaryotic 3 0 0 0
GBRA4-6-E GABA Receptor Alpha-4 Subunit (cluster #6 Of 7), Eukaryotic 4 4 1 1
GBRA4-7-E GABA Receptor Alpha-4 Subunit (cluster #7 Of 7), Eukaryotic 4 4 1 1
Uniprot Swissprot Chembl Description Number Shared
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 331
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 329
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 329
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 328
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 324
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 273
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 273
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 243
GBRD_HUMAN O14764 CHEMBL3591 GABA Receptor Delta Subunit, Human 243
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 242
GBRE_HUMAN P78334 CHEMBL4635 GABA Receptor Epsilon Subunit, Human 241
GBRG1_HUMAN Q8N1C3 CHEMBL4044 GABA Receptor Gamma-1 Subunit, Human 241
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 241
GBRP_HUMAN O00591 CHEMBL3506 GABA Receptor Pi Subunit, Human 241
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 166
GBRA2_RAT P23576 CHEMBL341 GABA Receptor Alpha-2 Subunit, Rat 48
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 34
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 10
GBRA1_RAT P62813 CHEMBL343 GABA Receptor Alpha-1 Subunit, Rat 9
GBRB2_RAT P63138 CHEMBL295 GABA Receptor Beta-2 Subunit, Rat 8
GBRG2_RAT P18508 CHEMBL297 GABA Receptor Gamma-2 Subunit, Rat 8
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 7
GBRA5_RAT P19969 CHEMBL300 GABA Receptor Alpha-5 Subunit, Rat 7
GBRB3_RAT P63079 CHEMBL316 GABA Receptor Beta-3 Subunit, Rat 7
GBRA1_BOVIN P08219 CHEMBL3627 GABA Receptor Alpha-1 Subunit, Bovin 4
GBRA2_BOVIN P10063 CHEMBL2321 GABA Receptor Alpha-2 Subunit, Bovin 4
GBRA3_BOVIN P10064 CHEMBL3628 GABA Receptor Alpha-3 Subunit, Bovin 4
GBRA4_BOVIN P20237 CHEMBL3140 GABA Receptor Alpha-4 Subunit, Bovin 4
GBRB1_BOVIN P08220 CHEMBL2848 GABA Receptor Beta-1 Subunit, Bovin 4
GBRG1_RAT P23574 CHEMBL296 GABA Receptor Gamma-1 Subunit, Rat 4
GBRG2_BOVIN P22300 CHEMBL5138 GABA Receptor Gamma-2 Subunit, Bovin 4
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 3
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 3
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 3
CDK1_HUMAN P06493 CHEMBL308 Cyclin-dependent Kinase 1, Human 3
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 3
GBRA3_RAT P20236 CHEMBL328 GABA Receptor Alpha-3 Subunit, Rat 3
GBRR1_HUMAN P24046 CHEMBL3561 GABA Receptor Rho-1 Subunit, Human 3
GBRR2_HUMAN P28476 CHEMBL2375 GABA Receptor Rho-2 Subunit, Human 3
XDH_HUMAN P47989 CHEMBL1929 Xanthine Dehydrogenase, Human 3
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2
A2AMW3_MOUSE A2AMW3 CHEMBL3121 GABA Receptor Epsilon Subunit, Mouse 2
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
CCNB1_HUMAN P14635 CHEMBL2412 G2/mitotic-specific Cyclin B1, Human 2
CCNB2_HUMAN O95067 CHEMBL3723 G2/mitotic-specific Cyclin B2, Human 2
CCNB3_HUMAN Q8WWL7 CHEMBL3606 G2/mitotic-specific Cyclin B3, Human 2
CDK6_HUMAN Q00534 CHEMBL2508 Cyclin-dependent Kinase 6, Human 2
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 2
GBRA1_MOUSE P62812 CHEMBL3139 GABA Receptor Alpha-1 Subunit, Mouse 2
GBRA2_MOUSE P26048 CHEMBL2705 GABA Receptor Alpha-2 Subunit, Mouse 2
GBRA3_MOUSE P26049 CHEMBL3387 GABA Receptor Alpha-3 Subunit, Mouse 2
GBRA4_MOUSE Q9D6F4 CHEMBL4182 GABA Receptor Alpha-4 Subunit, Mouse 2
GBRA4_RAT P28471 CHEMBL292 GABA Receptor Alpha-4 Subunit, Rat 2
GBRA5_MOUSE Q8BHJ7 CHEMBL2304 GABA Receptor Alpha-5 Subunit, Mouse 2
GBRA6_MOUSE P16305 CHEMBL4710 GABA Receptor Alpha-6 Subunit, Mouse 2
GBRA6_RAT P30191 CHEMBL293 GABA Receptor Alpha-6 Subunit, Rat 2
GBRB1_MOUSE P50571 CHEMBL2839 GABA Receptor Beta-1 Subunit, Mouse 2
GBRB3_MOUSE P63080 CHEMBL4231 GABA Receptor Beta-3 Subunit, Mouse 2
GBRD_MOUSE P22933 CHEMBL3907 GABA Receptor Delta Subunit, Mouse 2
GBRG1_MOUSE Q9R0Y8 CHEMBL2891 GABA Receptor Gamma-1 Subunit, Mouse 2
GBRG2_MOUSE P22723 CHEMBL2941 GABA Receptor Gamma-2 Subunit, Mouse 2
GBRG3_MOUSE P27681 CHEMBL4236 GABA Receptor Gamma-3 Subunit, Mouse 2
GBRP_MOUSE Q8QZW7 CHEMBL2746 GABA Receptor Pi Subunit, Mouse 2
GBRR3_HUMAN A8MPY1 CHEMBL2394 GABA Receptor Rho-3 Subunit, Human 2
GBRT_MOUSE Q9JLF1 CHEMBL3249 GABA Receptor Theta Subunit, Mouse 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 2
Z104294 Z104294 CHEMBL1907600 Cyclin-dependent Kinase 5/CDK5 Activator 1 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 1
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
ALDR_BOVIN P16116 CHEMBL3081 Aldose Reductase, Bovin 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
ALDR_RAT P07943 CHEMBL2622 Aldose Reductase, Rat 1
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 1
BACE1_HUMAN P56817 CHEMBL4822 Beta-secretase 1, Human 1
BGLR_RAT P06760 CHEMBL4814 Beta-glucuronidase, Rat 1
CBR1_HUMAN P16152 CHEMBL5586 Carbonyl Reductase [NADPH] 1, Human 1
CCKAR_RAT P30551 CHEMBL2871 Cholecystokinin A Receptor, Rat 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK2B_HUMAN P67870 CHEMBL2358 Casein Kinase II Beta, Human 1
DHB1_HUMAN P14061 CHEMBL3181 Estradiol 17-beta-dehydrogenase 1, Human 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 1
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 1
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 1
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 1
GABR1_RAT Q9Z0U4 CHEMBL2753 GABA-B Receptor 1, Rat 1
GABR2_HUMAN O75899 CHEMBL5034 GABA-B Receptor 2, Human 1
GABR2_RAT O88871 CHEMBL4686 GABA-B Receptor 2, Rat 1
GASR_RAT P30553 CHEMBL3508 Cholecystokinin B Receptor, Rat 1
GBRB1_RAT P15431 CHEMBL334 GABA Receptor Beta-1 Subunit, Rat 1
GBRD_RAT P18506 CHEMBL337 GABA Receptor Delta Subunit, Rat 1
GBRE_RAT Q9ES14 CHEMBL306 GABA Receptor Epsilon Subunit, Rat 1
GBRG3_RAT P28473 CHEMBL336 GABA Receptor Gamma-3 Subunit, Rat 1
GBRR1_RAT P50572 CHEMBL3588 GABA Receptor Rho-1 Subunit, Rat 1
KD4DL_HUMAN B2RXH2 CHEMBL1293226 Lysine-specific Demethylase 4D-like, Human 1
LOX12_HUMAN P18054 CHEMBL3687 Arachidonate 12-lipoxygenase, Human 1
LOX15_HUMAN P16050 CHEMBL2903 Arachidonate 15-lipoxygenase, Human 1
LX12L_RAT Q02759 CHEMBL2741 Arachidonate 12-lipoxygenase, Rat 1
LX15B_RAT Q8K4F2 CHEMBL3289 Arachidonate 15-lipoxygenase, Type II, Rat 1
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 1
NOX4_HUMAN Q9NPH5 CHEMBL1250375 NADPH Oxidase 4, Human 1
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 1
OPRD_PIG P79291 CHEMBL4103 Delta Opioid Receptor, Pig 1
P90584_PLAFA P90584 CHEMBL4090 Protein Kinase Pfmrk, Plafa 1
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 1
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 1
Q7ZJM1_9HIV1 Q7ZJM1 CHEMBL3471 Human Immunodeficiency Virus Type 1 Integrase, 9hiv1 1
Q91ZM7_RAT Q91ZM7 CHEMBL305 GABA Receptor Theta Subunit, Rat 1
Q965D6_PLAFA Q965D6 CHEMBL4513 3-oxoacyl-acyl-carrier Protein Reductase, Plafa 1
S6A11_HUMAN P48066 CHEMBL5208 GABA Transporter 3, Human 1
S6A11_RAT P31647 CHEMBL3598 GABA Transporter 3, Rat 1
S6A12_RAT P48056 CHEMBL5248 Betaine Transporter, Rat 1
S6A13_RAT P31646 CHEMBL4889 GABA Transporter 2, Rat 1
SC6A1_HUMAN P30531 CHEMBL1903 GABA Transporter 1, Human 1
SC6A1_RAT P23978 CHEMBL4054 GABA Transporter 1, Rat 1
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 1
XDH_BOVIN P80457 CHEMBL3649 Xanthine Dehydrogenase, Bovin 1