UCSF

Cyclooxygenase-2, Mouse (250 Compounds)

Swissprot:
PGH2_MOUSE
Stitch:
PGH2_MOUSE
UniProt:
Q05769
ChEMBL:
CHEMBL4321
Reactome:
REACT_211619
REACT_196559
REACT_188623
PDB:
1CVU (DOCK)
1CX2 (DOCK)
1DCX (DOCK)
1DD0 (DOCK)
1DDX (DOCK)
1PXX (DOCK)
3HS5 (DOCK)
3HS6 (DOCK)
3HS7 (DOCK)
3KRK (DOCK)
3LN0 (DOCK)
3LN1 (DOCK)
3MDL (DOCK)
3MQE (DOCK)
3NT1 (DOCK)
3NTB (DOCK)
3NTG (DOCK)
3OLT (DOCK)
3OLU (DOCK)
3PGH (DOCK)
3Q7D (DOCK)
3QH0 (DOCK)
3QMO (DOCK)
3RR3 (DOCK)
4COX (DOCK)
5COX (DOCK)
6COX (DOCK)
Ptgs2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 250 33 15 9
Binding ≤ 1μM 210 23 12 9
Functional ≤ 10μM 19 3 3 3
Uniprot Swissprot Chembl Description Number Shared
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 48
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 90 15 11 11
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2,153 141 77 52
PGH2_RABIT O02768 CHEMBL1293198 Prostaglandin G/H Synthase 2, Rabit 10 2 2 1
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 279 32 18 16
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 284 34 17 15
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 37 7 3 3

Clustered By Gene (0)

Clustered By Organism (7)

Code Description Substances Purchasable Natural In Man
PGH2-1-E Cyclooxygenase-2 (cluster #1 Of 8), Eukaryotic 896 75 38 27
PGH2-2-E Cyclooxygenase-2 (cluster #2 Of 8), Eukaryotic 35 6 4 1
PGH2-3-E Cyclooxygenase-2 (cluster #3 Of 8), Eukaryotic 106 28 14 10
PGH2-4-E Cyclooxygenase-2 (cluster #4 Of 8), Eukaryotic 1,428 55 26 20
PGH2-5-E Cyclooxygenase-2 (cluster #5 Of 8), Eukaryotic 2 2 2 0
PGH2-6-E Cyclooxygenase-2 (cluster #6 Of 8), Eukaryotic 11 8 7 7
PGH2-7-E Cyclooxygenase-2 (cluster #7 Of 8), Eukaryotic 178 7 10 3
PGH2-8-E Cyclooxygenase-2 (cluster #8 Of 8), Eukaryotic 290 27 8 8
Uniprot Swissprot Chembl Description Number Shared
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 97
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 94
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 48
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 24
PGH1_SHEEP P05979 CHEMBL2949 Cyclooxygenase-1, Sheep 24
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 21
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 20
LOX5_MOUSE P48999 CHEMBL5211 Arachidonate 5-lipoxygenase, Mouse 6
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 6
FABPL_RAT P02692 CHEMBL5738 Fatty Acid-binding Protein, Liver, Rat 4
CXCR1_HUMAN P25024 CHEMBL4029 Interleukin-8 Receptor A, Human 3
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 3
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 3
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 3
CXCR2_HUMAN P25025 CHEMBL2434 Interleukin-8 Receptor B, Human 2
IL8_HUMAN P10145 CHEMBL2157 Interleukin-8, Human 2
NOS2_MOUSE P29477 CHEMBL3464 Nitric Oxide Synthase, Inducible, Mouse 2
AK1C3_HUMAN P42330 CHEMBL4681 Aldo-keto-reductase Family 1 Member C3, Human 1
ALDR_HUMAN P15121 CHEMBL1900 Aldose Reductase, Human 1
B5SU02_9CNID B5SU02 CHEMBL1075028 Alpha Carbonic Anhydrase, 9cnid 1
C0IX24_9CNID C0IX24 CHEMBL1649055 Carbonic Anhydrase, 9cnid 1
CAH12_HUMAN O43570 CHEMBL3242 Carbonic Anhydrase XII, Human 1
CAH13_HUMAN Q8N1Q1 CHEMBL3912 Carbonic Anhydrase XIII, Human 1
CAH14_HUMAN Q9ULX7 CHEMBL3510 Carbonic Anhydrase XIV, Human 1
CAH15_MOUSE Q99N23 CHEMBL5973 Carbonic Anhydrase 15, Mouse 1
CAH2_HUMAN P00918 CHEMBL205 Carbonic Anhydrase II, Human 1
CAH4_BOVIN Q95323 CHEMBL281 Carbonic Anhydrase IV, Bovin 1
CAH4_HUMAN P22748 CHEMBL3729 Carbonic Anhydrase IV, Human 1
CAH5A_HUMAN P35218 CHEMBL4789 Carbonic Anhydrase VA, Human 1
CAH5B_HUMAN Q9Y2D0 CHEMBL3969 Carbonic Anhydrase VB, Human 1
CAH6_HUMAN P23280 CHEMBL3025 Carbonic Anhydrase VI, Human 1
CAH7_HUMAN P43166 CHEMBL2326 Carbonic Anhydrase VII, Human 1
CAH9_HUMAN Q16790 CHEMBL3594 Carbonic Anhydrase IX, Human 1
CAH_METTE P40881 CHEMBL3932 Carbonic Anhydrase, Mette 1
CAN_YEAST P53615 CHEMBL5931 Carbonic Anhydrase, Yeast 1
COX2_SHEEP O78750 CHEMBL1250404 Cytochrome C Oxidase Subunit 2, Sheep 1
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
CYNT_MYCTU O53573 CHEMBL6068 Carbonic Anhydrase, Myctu 1
FABPI_HUMAN P12104 CHEMBL4879 Fatty Acid Binding Protein Intestinal, Human 1
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GPR44_HUMAN Q9Y5Y4 CHEMBL5071 G Protein-coupled Receptor 44, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
PA24A_HUMAN P47712 CHEMBL3816 Cytosolic Phospholipase A2, Human 1
PGH2_RABIT O02768 CHEMBL1293198 Prostaglandin G/H Synthase 2, Rabit 1
PTGDS_MOUSE O09114 CHEMBL4334 Prostaglandin-H2 D-isomerase, Mouse 1
Q5AJ71_CANAL Q5AJ71 CHEMBL5337 Carbonic Anhydrase, Canal 1
Q8HZR1_CANFA Q8HZR1 CHEMBL4133 Cyclooxygenase-1, Canine 1
Q8SPQ9_CANFA Q8SPQ9 CHEMBL4033 Cyclooxygenase-2, Canine 1
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 1
Z100741 Z100741 CHEMBL614867 MC9 (Mast Cells) 1
Z102213 Z102213 CHEMBL613416 Blood 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1