UCSF

Thromboxane-A Synthase, Human (972 Compounds)

Swissprot:
THAS_HUMAN
Stitch:
THAS_HUMAN
UniProt:
P24557
ChEMBL:
CHEMBL1835
Reactome:
REACT_13645
REACT_150149
PDB:
TBXAS1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 972 36 9 8
Binding ≤ 1μM 849 30 9 8
Functional ≤ 10μM 152 4 5 6

Reactome Network (2)

Reactome ID Description Species
REACT_13645 Eicosanoids Homo sapiens
REACT_150149 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PTGIS_HUMAN Q16647 CHEMBL4428 Prostaglandin I2 Synthase, Human 64

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Uniprot Swissprot Chembl Description Number Shared
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 2
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 5
PTGIS_HUMAN Q16647 CHEMBL4428 Prostaglandin I2 Synthase, Human 64
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
THAS_RAT P49430 CHEMBL4028 Thromboxane-A Synthase, Rat 184 22 4 4

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
THAS-1-E Thromboxane-A Synthase (cluster #1 Of 3), Eukaryotic 873 20 6 6
THAS-2-E Thromboxane-A Synthase (cluster #2 Of 3), Eukaryotic 158 9 1 1
THAS-3-E Thromboxane-A Synthase (cluster #3 Of 3), Eukaryotic 111 26 2 1
Uniprot Swissprot Chembl Description Number Shared
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 74
PTGIS_HUMAN Q16647 CHEMBL4428 Prostaglandin I2 Synthase, Human 64
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 35
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 25
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 23
THAS_RAT P49430 CHEMBL4028 Thromboxane-A Synthase, Rat 20
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 18
PTAFR_MOUSE Q62035 CHEMBL3993 Platelet Activating Factor Receptor, Mouse 17
PTAFR_RAT P46002 CHEMBL4127 Platelet Activating Factor Receptor, Rat 17
ACE_HUMAN P12821 CHEMBL1808 Angiotensin-converting Enzyme, Human 10
Z50587 Z50587 CHEMBL372 Homo Sapiens 6
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 6
C11B1_RAT P15393 CHEMBL4970 Cytochrome P450 11B1, Rat 4
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 4
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 4
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 4
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 4
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 4
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 4
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 4
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 4
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 4
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 4
PTGES_HUMAN O14684 CHEMBL5658 Prostaglandin E Synthase, Human 4
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 4
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 3
LT4R1_HUMAN Q15722 CHEMBL3911 Leukotriene B4 Receptor 1, Human 3
CLTR2_HUMAN Q9NS75 CHEMBL4330 Cysteinyl Leukotriene Receptor 2, Human 2
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 2
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 2
PGES2_HUMAN Q9H7Z7 CHEMBL4411 Prostaglandin E Synthase 2, Human 2
PGH1_BOVIN O62664 CHEMBL2860 Cyclooxygenase-1, Bovin 2
PGH1_HUMAN P23219 CHEMBL221 Cyclooxygenase-1, Human 2
PGH2_BOVIN O62698 CHEMBL3331 Cyclooxygenase-2, Bovin 2
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 2
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 2
Z50512 Z50512 CHEMBL369 Cavia Porcellus 2
AL5AP_HUMAN P20292 CHEMBL4550 5-lipoxygenase Activating Protein, Human 1
C11B1_HUMAN P15538 CHEMBL1908 Cytochrome P450 11B1, Human 1
C11B2_HUMAN P19099 CHEMBL2722 Cytochrome P450 11B2, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
PGH1_MOUSE P22437 CHEMBL2649 Cyclooxygenase-1, Mouse 1
PGH1_RAT Q63921 CHEMBL4042 Cyclooxygenase-1, Rat 1
PGH2_MOUSE Q05769 CHEMBL4321 Cyclooxygenase-2, Mouse 1
PGH2_RAT P35355 CHEMBL2977 Cyclooxygenase-2, Rat 1
PGH2_SHEEP P79208 CHEMBL4102 Cyclooxygenase-2, Sheep 1
Q2TJZ7_PIG Q2TJZ7 CHEMBL5152 Microsomal Prostaglandin E Synthase-1, Pig 1
Z102213 Z102213 CHEMBL613416 Blood 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z80216 Z80216 CHEMBL614042 MAC13 1
Z80218 Z80218 CHEMBL614318 MAC16 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80419 Z80419 CHEMBL614772 RBL-1 (Basophilic Leukemia Cells) 1
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 1
Z81267 Z81267 CHEMBL614723 Mononuclear Cell Line 1

Most Common Rings