UCSF

Platelet Activating Factor Receptor, Human (769 Compounds)

Swissprot:
PTAFR_HUMAN
Stitch:
PTAFR_HUMAN
UniProt:
P25105
ChEMBL:
CHEMBL250
Reactome:
REACT_14828
REACT_18283
REACT_25078
PDB:
2B0X (DOCK)
PTAFR

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 769 26 16 6
Binding ≤ 1μM 643 22 10 6
Functional ≤ 10μM 1,432 21 3 7

Reactome Network (3)

Reactome ID Description Species
REACT_14828 Class A/1 (Rhodopsin-like receptors) Homo sapiens
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_25078 Interferon gamma signaling Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 3
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PTAFR_CAVPO P21556 CHEMBL5136 Platelet Activating Factor Receptor, Guinea Pig 30 0 0 0
PTAFR_MOUSE Q62035 CHEMBL3993 Platelet Activating Factor Receptor, Mouse 26 0 0 0
PTAFR_RAT P46002 CHEMBL4127 Platelet Activating Factor Receptor, Rat 4 1 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PTAFR-1-E Platelet Activating Factor Receptor (cluster #1 Of 2), Eukaryotic 245 11 5 3
PTAFR-2-E Platelet Activating Factor Receptor (cluster #2 Of 2), Eukaryotic 593 18 14 3
Uniprot Swissprot Chembl Description Number Shared
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 37
THAS_HUMAN P24557 CHEMBL1835 Thromboxane-A Synthase, Human 35
PTAFR_RAT P46002 CHEMBL4127 Platelet Activating Factor Receptor, Rat 23
LOX5_RAT P12527 CHEMBL312 Arachidonate 5-lipoxygenase, Rat 21
PTAFR_MOUSE Q62035 CHEMBL3993 Platelet Activating Factor Receptor, Mouse 21
Z50512 Z50512 CHEMBL369 Cavia Porcellus 7
Z80156 Z80156 CHEMBL383 HL-60 (Promyeloblast Leukemia Cells) 5
Z102256 Z102256 CHEMBL613450 Plasma 4
Z50587 Z50587 CHEMBL372 Homo Sapiens 4
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 4
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 3
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 3
CLTR1_HUMAN Q9Y271 CHEMBL1798 Cysteinyl Leukotriene Receptor 1, Human 3
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 2
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
Z50417 Z50417 CHEMBL612848 Leishmania Infantum 2
Z50588 Z50588 CHEMBL373 Canis Familiaris 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
Z80166 Z80166 CHEMBL384 HT-29 (Colon Adenocarcinoma Cells) 2
Z80186 Z80186 CHEMBL385 K562 (Erythroleukemia Cells) 2
Z80678 Z80678 CHEMBL614270 AMML Cell Line 2
Z80777 Z80777 CHEMBL614800 CML/BC Cell Line 2
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 2
Z81252 Z81252 CHEMBL400 MDA-MB-231 (Breast Adenocarcinoma Cells) 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 1
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 1
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 1
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 1
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 1
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 1
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 1
GLRA1_HUMAN P23415 CHEMBL5845 Glycine Receptor Subunit Alpha-1, Human 1
GLRA2_HUMAN P23416 CHEMBL5871 Glycine Receptor Subunit Alpha-2, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 1
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 1
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 1
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 1
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 1
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 1

Most Common Rings