UCSF

Kappa Opioid Receptor, Human (3,585 Compounds)

Swissprot:
OPRK_HUMAN
Stitch:
OPRK_HUMAN
UniProt:
P41145
ChEMBL:
CHEMBL237
Reactome:
REACT_19231
REACT_14819
PDB:
2A0D (DOCK)
2IQN (DOCK)
OPRK1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3,585 110 54 58
Binding ≤ 1μM 2,895 97 47 53
Functional ≤ 10μM 470 17 7 5

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 11
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 6
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 3
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 3
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 4
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 15
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 7
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 6
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 7
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 6
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 3
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 6
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 15
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 21
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 13
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 5
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 2005
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2401
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 540
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 3
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 2005
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2401
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 540
UR2R_HUMAN Q9UKP6 CHEMBL3764 Urotensin II Receptor, Human 74
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 482 25 19 19
OPRK_MOUSE P33534 CHEMBL4329 Kappa Opioid Receptor, Mouse 125 13 9 8
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 568 51 34 45

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
OPRK-1-E Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic 4,070 135 65 88
OPRK-2-E Kappa Opioid Receptor (cluster #2 Of 6), Eukaryotic 3 3 1 1
OPRK-3-E Kappa Opioid Receptor (cluster #3 Of 6), Eukaryotic 269 8 8 5
OPRK-4-E Kappa Opioid Receptor (cluster #4 Of 6), Eukaryotic 265 14 5 9
OPRK-5-E Kappa Opioid Receptor (cluster #5 Of 6), Eukaryotic 10 1 4 0
OPRK-6-E Kappa Opioid Receptor (cluster #6 Of 6), Eukaryotic 1 0 1 1
Uniprot Swissprot Chembl Description Number Shared
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 2396
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 2005
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 540
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 513
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 291
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 162
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 65
OPRM_MOUSE P42866 CHEMBL2858 Mu Opioid Receptor, Mouse 63
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 54
OPRM_BOVIN P79350 CHEMBL3041 Mu Opioid Receptor, Bovin 54
OPRM_CAVPO P97266 CHEMBL4354 Mu Opioid Receptor, Guinea Pig 54
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 53
OPRD_MOUSE P32300 CHEMBL3222 Delta Opioid Receptor, Mouse 44
OPRD_PIG P79291 CHEMBL4103 Delta Opioid Receptor, Pig 38
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 38
OPRK_MOUSE P33534 CHEMBL4329 Kappa Opioid Receptor, Mouse 27
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 23
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 21
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 18
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 17
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 17
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 17
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 15
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 15
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 15
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 15
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 14
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 14
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 13
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 13
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 13
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 12
SGMR1_MOUSE O55242 CHEMBL3465 Sigma Opioid Receptor, Mouse 12
Z50512 Z50512 CHEMBL369 Cavia Porcellus 12
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 11
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 11
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 11
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 11
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 11
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 10
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 10
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 9
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 9
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 9
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 8
Z50594 Z50594 CHEMBL375 Mus Musculus 8
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 7
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 7
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 7
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 7
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 6
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 6
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 6
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 6
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 6
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 6
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 6
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 5
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 5
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 5
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 5
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 5
NMD3B_RAT Q8VHN2 CHEMBL282 Glutamate [NMDA] Receptor Subunit 3B, Rat 5
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 5
NMDE4_RAT Q62645 CHEMBL303 Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat 5
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 5
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 4
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 4
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 4
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 4
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 4
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 3
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 3
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 3
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 3
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 3
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 3
CNR2_HUMAN P34972 CHEMBL253 Cannabinoid CB2 Receptor, Human 3
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 3
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 3
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 3
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 3
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 2
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 2
CAC1I_HUMAN Q9P0X4 CHEMBL5558 Voltage-gated T-type Calcium Channel Alpha-1I Subunit, Human 2
CAC1S_RAT Q02485 CHEMBL4108 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Rat 2
CCKAR_RAT P30551 CHEMBL2871 Cholecystokinin A Receptor, Rat 2
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 2
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 2
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
OPRX_RAT P35370 CHEMBL4503 Nociceptin Receptor, Rat 2
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 2
TSPOB_HUMAN B1AH88 CHEMBL5139 Peripheral-type Benzodiazepine Receptor, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104287 Z104287 CHEMBL1907593 Neuronal Acetylcholine Receptor; Alpha3/beta4 2
Z104290 Z104290 CHEMBL1907596 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 2
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 1
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 1
AGTR1_HUMAN P30556 CHEMBL227 Angiotensin II Type 1 Receptor, Human 1
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 1
CA2D1_RAT P54290 CHEMBL3420 Voltage-gated Calcium Channel Alpha2/delta Subunit 1, Rat 1
CAC1B_RAT Q02294 CHEMBL5107 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Rat 1
CACB1_RAT P54283 CHEMBL1075136 Voltage-dependent L-type Calcium Channel Subunit Beta-1, Rat 1
CCR5_MOUSE P51682 CHEMBL3676 C-C Chemokine Receptor Type 5, Mouse 1
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 1
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 1
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
GNRHR_RAT P30969 CHEMBL3066 Gonadotropin-releasing Hormone Receptor, Rat 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NK1R_RAT P14600 CHEMBL4027 Neurokinin 1 Receptor, Rat 1
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 1
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 1
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 1
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 1
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 1
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 1
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 1
OXYR_HUMAN P30559 CHEMBL2049 Oxytocin Receptor, Human 1
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
PTAFR_HUMAN P25105 CHEMBL250 Platelet Activating Factor Receptor, Human 1
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN1A_RAT P04774 CHEMBL4906 Sodium Channel Protein Type I Alpha Subunit, Rat 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN3A_RAT P08104 CHEMBL4966 Sodium Channel Protein Type III Alpha Subunit, Rat 1
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1
TSPOA_HUMAN P30536 CHEMBL5742 Translocator Protein, Human 1
UR2R_HUMAN Q9UKP6 CHEMBL3764 Urotensin II Receptor, Human 1
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 1