UCSF

Beta-3 Adrenergic Receptor, Human (495 Compounds)

Swissprot:
ADRB3_HUMAN
Stitch:
ADRB3_HUMAN
UniProt:
P13945
ChEMBL:
CHEMBL246
Reactome:
REACT_16927
REACT_19327
PDB:
2CDW (DOCK)
ADRB3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 495 33 9 11
Binding ≤ 1μM 374 16 5 7
Functional ≤ 10μM 1,150 19 7 9

Reactome Network (2)

Reactome ID Description Species
REACT_16927 Adrenoceptors Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 7
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 9
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 9
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 8
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 8
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 7
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 874
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 687

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 874
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 687
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 3
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB3_BOVIN P46626 CHEMBL3083 Beta-3 Adrenergic Receptor, Bovin 6 2 2 2
ADRB3_MOUSE P25962 CHEMBL4030 Beta-3 Adrenergic Receptor, Mouse 17 0 0 0
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 208 29 27 20
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 760 58 28 26
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 834 83 38 41

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
ADRB3-1-E Beta-3 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic 560 31 22 15
ADRB3-2-E Beta-3 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic 164 29 13 13
Uniprot Swissprot Chembl Description Number Shared
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 614
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 416
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 38
ADRB3_CANFA O02662 CHEMBL4400 Beta-3 Adrenergic Receptor, Canine 26
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 19
Z50588 Z50588 CHEMBL373 Canis Familiaris 16
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 14
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 13
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 11
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 7
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 7
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 6
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 6
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 6
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 6
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 6
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 5
Z50512 Z50512 CHEMBL369 Cavia Porcellus 5
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 4
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 4
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 4
CASR_HUMAN P41180 CHEMBL1878 Calcium Sensing Receptor, Human 4
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 4
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 4
NMT1_HUMAN P30419 CHEMBL2593 Peptide N-myristoyltransferase 1, Human 4
NMT2_HUMAN O60551 CHEMBL2849 Peptide N-myristoyltransferase 2, Human 4
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 4
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 3
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 3
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 3
ADRB3_MOUSE P25962 CHEMBL4030 Beta-3 Adrenergic Receptor, Mouse 3
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 3
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 3
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 3
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 3
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 3
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 2
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 2
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 2
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 2
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 2
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 2
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 2
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 2
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 2
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 2
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 2
ADRB1_MOUSE P34971 CHEMBL3440 Beta-1 Adrenergic Receptor, Mouse 2
ADRB2_BOVIN Q28044 CHEMBL3373 Beta-2 Adrenergic Receptor, Bovin 2
ADRB2_MESAU P04274 CHEMBL5943 Beta-2 Adrenergic Receptor, Mesau 2
ADRB2_MOUSE P18762 CHEMBL3707 Beta-2 Adrenergic Receptor, Mouse 2
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 2
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 2
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 2
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 2
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 2
FDFT_RAT Q02769 CHEMBL3815 Squalene Synthetase, Rat 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 2
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 2
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 2
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 2
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 2
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50587 Z50587 CHEMBL372 Homo Sapiens 2
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 2
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 1
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 1
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 1
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 1
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 1
ADA1A_RABIT O02824 CHEMBL3637 Alpha-1a Adrenergic Receptor, Rabit 1
ADA1D_RABIT O02666 CHEMBL4407 Alpha-1d Adrenergic Receptor, Rabit 1
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 1
GHSR_HUMAN Q92847 CHEMBL4616 Ghrelin Receptor, Human 1
LOX5_HUMAN P09917 CHEMBL215 Arachidonate 5-lipoxygenase, Human 1
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 1
PD2R_HUMAN Q13258 CHEMBL4427 Prostanoid DP Receptor, Human 1
PE2R3_HUMAN P43115 CHEMBL3710 Prostanoid EP3 Receptor, Human 1
PE2R4_HUMAN P35408 CHEMBL1836 Prostanoid EP4 Receptor, Human 1
PF2R_HUMAN P43088 CHEMBL1987 Prostanoid FP Receptor, Human 1
PI2R_HUMAN P43119 CHEMBL1995 Prostanoid IP Receptor, Human 1
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 1
TA2R_HUMAN P21731 CHEMBL2069 Thromboxane A2 Receptor, Human 1