ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Names
Compounds (935)
Reactome (2)
Related By:
Pathway (36)
Organism (1)
Gene (0)
Org. Clust. (1)
ChEMBL (160)
Rings (50)

Serotonin 1b (5-HT1b) Receptor, Human (935 Compounds)

Swissprot:: 5HT1B_HUMAN
Stitch:: 5HT1B_HUMAN
UniProt:: P28222
ChEMBL:: CHEMBL1898
Reactome:: REACT_19231; REACT_17064
PDB:: 2G1X (DOCK); HTR1B

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	935	52	20	18
Binding ≤ 1μM	822	43	18	16
Functional ≤ 10μM	83	20	6	6

Reactome ID	Description	Species
REACT_19231	G alpha (i) signalling events	Homo sapiens
REACT_17064	Serotonin receptors	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	422
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	843
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	27
5HT1F_HUMAN	P30939	CHEMBL1805	Serotonin 1f (5-HT1f) Receptor, Human	68
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	19
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	3
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	9
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	7
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	5
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	23
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	19
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	26
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	3
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	60
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	52
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	39
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	5
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
MCHR1_HUMAN	Q99705	CHEMBL344	Melanin-concentrating Hormone Receptor 1, Human	2
MCHR2_HUMAN	Q969V1	CHEMBL5038	Melanin-concentrating Hormone Receptor 2, Human	1
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	3
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	4
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	6
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	9

Serotonin receptors

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	422
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	843
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	27
5HT1F_HUMAN	P30939	CHEMBL1805	Serotonin 1f (5-HT1f) Receptor, Human	68
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	84
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	65
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	94
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	18
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	19
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	63
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	61

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	452	138	55	52

Clustered By Gene (0)

Clustered By Organism (1)

Code	Description	Substances	Purchasable	Natural	In Man
5HT1B-1-E	Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic	1,381	178	69	67
5HT1B-2-E	Serotonin 1b (5-HT1b) Receptor (cluster #2 Of 2), Eukaryotic	4	2	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
5HT1D_HUMAN	P28221	CHEMBL1983	Serotonin 1d (5-HT1d) Receptor, Human	843
5HT1A_HUMAN	P08908	CHEMBL214	Serotonin 1a (5-HT1a) Receptor, Human	389
DRD2_RAT	P61169	CHEMBL339	Dopamine D2 Receptor, Rat	147
5HT1A_RAT	P19327	CHEMBL273	Serotonin 1a (5-HT1a) Receptor, Rat	106
SC6A4_HUMAN	P31645	CHEMBL228	Serotonin Transporter, Human	105
5HT2C_HUMAN	P28335	CHEMBL225	Serotonin 2c (5-HT2c) Receptor, Human	92
SC6A4_RAT	P31652	CHEMBL313	Serotonin Transporter, Rat	91
5HT2A_HUMAN	P28223	CHEMBL224	Serotonin 2a (5-HT2a) Receptor, Human	82
DRD3_RAT	P19020	CHEMBL3138	Dopamine D3 Receptor, Rat	81
ADA1A_HUMAN	P35348	CHEMBL229	Alpha-1a Adrenergic Receptor, Human	73
Z104304	Z104304	CHEMBL1907610	Adrenergic Receptor Alpha-1	72
5HT1F_HUMAN	P30939	CHEMBL1805	Serotonin 1f (5-HT1f) Receptor, Human	68
5HT2A_RAT	P14842	CHEMBL322	Serotonin 2a (5-HT2a) Receptor, Rat	66
5HT2B_HUMAN	P41595	CHEMBL1833	Serotonin 2b (5-HT2b) Receptor, Human	65
5HT6R_HUMAN	P50406	CHEMBL3371	Serotonin 6 (5-HT6) Receptor, Human	63
5HT7R_HUMAN	P34969	CHEMBL3155	Serotonin 7 (5-HT7) Receptor, Human	59
DRD2_HUMAN	P14416	CHEMBL217	Dopamine D2 Receptor, Human	58
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	55
DRD3_HUMAN	P35462	CHEMBL234	Dopamine D3 Receptor, Human	50
5HT2C_RAT	P08909	CHEMBL324	Serotonin 2c (5-HT2c) Receptor, Rat	43
DRD4_HUMAN	P21917	CHEMBL219	Dopamine D4 Receptor, Human	39
ADA1B_HUMAN	P35368	CHEMBL232	Alpha-1b Adrenergic Receptor, Human	38
ADA1D_HUMAN	P25100	CHEMBL223	Alpha-1d Adrenergic Receptor, Human	30
5HT1E_HUMAN	P28566	CHEMBL2182	Serotonin 1e (5-HT1e) Receptor, Human	27
ADA2C_HUMAN	P18825	CHEMBL1916	Alpha-2c Adrenergic Receptor, Human	26
5HT1B_RAT	P28564	CHEMBL3459	Serotonin 1b (5-HT1b) Receptor, Rat	25
ADA1A_BOVIN	P18130	CHEMBL4892	Alpha-1a Adrenergic Receptor, Bovin	24
ADA2A_HUMAN	P08913	CHEMBL1867	Alpha-2a Adrenergic Receptor, Human	23
DRD1_HUMAN	P21728	CHEMBL2056	Dopamine D1 Receptor, Human	22
HRH1_HUMAN	P35367	CHEMBL231	Histamine H1 Receptor, Human	20
5HT5A_HUMAN	P47898	CHEMBL3426	Serotonin 5a (5-HT5a) Receptor, Human	19
ADA2B_HUMAN	P18089	CHEMBL1942	Alpha-2b Adrenergic Receptor, Human	19
5HT2B_RAT	P30994	CHEMBL323	Serotonin 2b (5-HT2b) Receptor, Rat	18
ADA1D_RAT	P23944	CHEMBL326	Alpha-1d Adrenergic Receptor, Rat	18
5HT4R_HUMAN	Q13639	CHEMBL1875	Serotonin 4 (5-HT4) Receptor, Human	17
5HT3A_HUMAN	P46098	CHEMBL1899	Serotonin 3a (5-HT3a) Receptor, Human	16
HRH2_HUMAN	P25021	CHEMBL1941	Histamine H2 Receptor, Human	16
ADA1B_MESAU	P18841	CHEMBL3122	Alpha-1b Adrenergic Receptor, Mesau	15
ADA2B_RAT	P19328	CHEMBL266	Alpha-2b Adrenergic Receptor, Rat	15
ADA2A_RAT	P22909	CHEMBL327	Alpha-2a Adrenergic Receptor, Rat	14
ADA2C_RAT	P22086	CHEMBL314	Alpha-2c Adrenergic Receptor, Rat	14
ERG_HUMAN	P11308	CHEMBL1293191	Transcriptional Regulator ERG, Human	14
DRD1_RAT	P18901	CHEMBL265	Dopamine D1 Receptor, Rat	13
DRD5_HUMAN	P21918	CHEMBL1850	Dopamine D5 Receptor, Human	12
SC6A3_HUMAN	Q01959	CHEMBL238	Dopamine Transporter, Human	12
5HT1D_RAT	P28565	CHEMBL5450	Serotonin 1d (5-HT1d) Receptor, Rat	10
SC6A2_HUMAN	P23975	CHEMBL222	Norepinephrine Transporter, Human	10
5HT3B_HUMAN	O95264	CHEMBL3895	Serotonin 3b (5-HT3b) Receptor, Human	9
5HT3E_HUMAN	A5X5Y0	CHEMBL3812	Serotonin 3e (5-HT3e) Receptor, Human	9
AA3R_HUMAN	P33765	CHEMBL256	Adenosine A3 Receptor, Human	9
ADA2A_BOVIN	Q28838	CHEMBL4744	Alpha-2a Adrenergic Receptor, Bovin	9
ADRB2_HUMAN	P07550	CHEMBL210	Beta-2 Adrenergic Receptor, Human	9
OPRM_HUMAN	P35372	CHEMBL233	Mu Opioid Receptor, Human	9
5HT1F_RAT	P30940	CHEMBL4646	Serotonin 1f (5-HT1f) Receptor, Rat	8
5HT3C_HUMAN	Q8WXA8	CHEMBL4795	Serotonin 3c (5-HT3c) Receptor, Human	8
5HT3D_HUMAN	Q70Z44	CHEMBL4673	Serotonin 3d (5-HT3d) Receptor, Human	8
DRD2_BOVIN	P20288	CHEMBL3998	Dopamine D2 Receptor, Bovin	8
SC6A9_HUMAN	P48067	CHEMBL2337	Glycine Transporter 1, Human	8
ACM2_HUMAN	P08172	CHEMBL211	Muscarinic Acetylcholine Receptor M2, Human	7
ADA1A_RAT	P43140	CHEMBL319	Alpha-1a Adrenergic Receptor, Rat	7
Q9WTR4_RAT	Q9WTR4	CHEMBL304	Norepinephrine Transporter, Rat	7
5HT1A_MOUSE	Q64264	CHEMBL3737	Serotonin 1a (5-HT1a) Receptor, Mouse	6
5HT2A_BOVIN	Q75Z89	CHEMBL3446	Serotonin 2a (5-HT2a) Receptor, Bovin	6
5HT3A_RAT	P35563	CHEMBL2411	Serotonin 3a (5-HT3a) Receptor, Rat	6
5HT3B_RAT	Q9JJ16	CHEMBL3458	Serotonin 3b (5-HT3b) Receptor, Rat	6
ACM1_HUMAN	P11229	CHEMBL216	Muscarinic Acetylcholine Receptor M1, Human	6
ADRB1_HUMAN	P08588	CHEMBL213	Beta-1 Adrenergic Receptor, Human	6
OPRK_HUMAN	P41145	CHEMBL237	Kappa Opioid Receptor, Human	6
SGMR1_HUMAN	Q99720	CHEMBL287	Sigma Opioid Receptor, Human	6
Z50597	Z50597	CHEMBL376	Rattus Norvegicus	6
5HT5A_RAT	P35364	CHEMBL4655	Serotonin 5a (5-HT5a) Receptor, Rat	5
5HT7R_RAT	P32305	CHEMBL3223	Serotonin 7 (5-HT7) Receptor, Rat	5
ACM3_HUMAN	P20309	CHEMBL245	Muscarinic Acetylcholine Receptor M3, Human	5
ACM4_HUMAN	P08173	CHEMBL1821	Muscarinic Acetylcholine Receptor M4, Human	5
ACM5_HUMAN	P08912	CHEMBL2035	Muscarinic Acetylcholine Receptor M5, Human	5
HRH3_HUMAN	Q9Y5N1	CHEMBL264	Histamine H3 Receptor, Human	5
NISCH_HUMAN	Q9Y2I1	CHEMBL3923	Nischarin, Human	5
ADA1B_RAT	P15823	CHEMBL315	Alpha-1b Adrenergic Receptor, Rat	4
OPRD_HUMAN	P41143	CHEMBL236	Delta Opioid Receptor, Human	4
5HT1D_PIG	P79400	CHEMBL4105	Serotonin 1d (5-HT1d) Receptor, Pig	3
5HT4R_CAVPO	O70528	CHEMBL5017	Serotonin 4 (5-HT4) Receptor, Guinea Pig	3
AA1R_HUMAN	P30542	CHEMBL226	Adenosine A1 Receptor, Human	3
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	3
DRD4_RAT	P30729	CHEMBL3361	Dopamine D4 Receptor, Rat	3
MT3_HUMAN	P25713	CHEMBL1250357	Metallothionein-3, Human	3
MTR1A_HUMAN	P48039	CHEMBL1945	Melatonin Receptor 1A, Human	3
NK2R_HUMAN	P21452	CHEMBL2327	Neurokinin 2 Receptor, Human	3
SGMR1_RAT	Q9R0C9	CHEMBL3602	Sigma Opioid Receptor, Rat	3
5HT3A_MOUSE	P23979	CHEMBL4972	Serotonin 3a (5-HT3a) Receptor, Mouse	2
5HT3B_MOUSE	Q9JHJ5	CHEMBL3781	Serotonin 3b (5-HT3b) Receptor, Mouse	2
5HT5A_MOUSE	P30966	CHEMBL3597	Serotonin 5a (5-HT5a) Receptor, Mouse	2
AA2AR_HUMAN	P29274	CHEMBL251	Adenosine A2a Receptor, Human	2
ACES_HUMAN	P22303	CHEMBL220	Acetylcholinesterase, Human	2
ADA2A_MOUSE	Q01338	CHEMBL4075	Alpha-2a Adrenergic Receptor, Mouse	2
ADA2A_PIG	P18871	CHEMBL2350	Alpha-2a Adrenergic Receptor, Pig	2
ADA2B_MOUSE	P30545	CHEMBL2405	Alpha-2b Adrenergic Receptor, Mouse	2
ADA2C_MOUSE	Q01337	CHEMBL4826	Alpha-2c Adrenergic Receptor, Mouse	2
ADCY3_RAT	P21932	CHEMBL4864	Adenylate Cyclase Type III, Rat	2
ADCY5_RAT	Q04400	CHEMBL2880	Adenylate Cyclase Type V, Rat	2
ADRB3_HUMAN	P13945	CHEMBL246	Beta-3 Adrenergic Receptor, Human	2
AOFA_HUMAN	P21397	CHEMBL1951	Monoamine Oxidase A, Human	2
EDNRA_HUMAN	P25101	CHEMBL252	Endothelin Receptor ET-A, Human	2
GASR_HUMAN	P32239	CHEMBL298	Cholecystokinin B Receptor, Human	2
GCR_HUMAN	P04150	CHEMBL2034	Glucocorticoid Receptor, Human	2
HRH1_CAVPO	P31389	CHEMBL3943	Histamine H1 Receptor, Guinea Pig	2
HRH4_HUMAN	Q9H3N8	CHEMBL3759	Histamine H4 Receptor, Human	2
LYN_HUMAN	P07948	CHEMBL3905	Tyrosine-protein Kinase Lyn, Human	2
MC4R_HUMAN	P32245	CHEMBL259	Melanocortin Receptor 4, Human	2
MCHR1_HUMAN	Q99705	CHEMBL344	Melanin-concentrating Hormone Receptor 1, Human	2
MK14_HUMAN	Q16539	CHEMBL260	MAP Kinase P38 Alpha, Human	2
NK1R_HUMAN	P25103	CHEMBL249	Neurokinin 1 Receptor, Human	2
NPY1R_HUMAN	P25929	CHEMBL4777	Neuropeptide Y Receptor Type 1, Human	2
NTR1_HUMAN	P30989	CHEMBL4123	Neurotensin Receptor 1, Human	2
SC5A7_HUMAN	Q9GZV3	CHEMBL4507	High-affinity Choline Transporter, Human	2
V1AR_HUMAN	P37288	CHEMBL1889	Vasopressin V1a Receptor, Human	2
Z104283	Z104283	CHEMBL1907589	Neuronal Acetylcholine Receptor; Alpha4/beta2	2
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	2
Z50588	Z50588	CHEMBL373	Canis Familiaris	2
Z50592	Z50592	CHEMBL374	Oryctolagus Cuniculus	2
Z80094	Z80094	CHEMBL614558	CHO-MG (Ovarian Cells)	2
Z81247	Z81247	CHEMBL399	HeLa (Cervical Adenocarcinoma Cells)	2
5HT1D_MOUSE	Q61224	CHEMBL4297	Serotonin 1d (5-HT1d) Receptor, Mouse	1
5HT2A_MOUSE	P35363	CHEMBL5377	Serotonin 2a (5-HT2a) Receptor, Mouse	1
5HT2B_MOUSE	Q02152	CHEMBL2583	Serotonin 2b (5-HT2b) Receptor, Mouse	1
5HT2C_MOUSE	P34968	CHEMBL3006	Serotonin 2c (5-HT2c) Receptor, Mouse	1
5HT4R_RAT	Q62758	CHEMBL4317	Serotonin 4 (5-HT4) Receptor, Rat	1
ACM5_RAT	P08911	CHEMBL277	Muscarinic Acetylcholine Receptor M5, Rat	1
ADA2B_BOVIN	O77700	CHEMBL3523	Alpha-2b Adrenergic Receptor, Bovin	1
ADCY1_HUMAN	Q08828	CHEMBL2899	Brain Adenylate Cyclase 1, Human	1
ADCY2_HUMAN	Q08462	CHEMBL3760	Adenylate Cyclase Type II, Human	1
ADCY8_HUMAN	P40145	CHEMBL2960	Adenylate Cyclase Type VIII, Human	1
AOFA_RAT	P21396	CHEMBL3358	Monoamine Oxidase A, Rat	1
AOFB_RAT	P19643	CHEMBL2993	Monoamine Oxidase B, Rat	1
CAC1C_HUMAN	Q13936	CHEMBL1940	Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human	1
CAC1D_HUMAN	Q01668	CHEMBL4138	Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human	1
CAC1F_HUMAN	O60840	CHEMBL5593	Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human	1
CAC1S_HUMAN	Q13698	CHEMBL3805	Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human	1
GNRHR_HUMAN	P30968	CHEMBL1855	Gonadotropin-releasing Hormone Receptor, Human	1
HRH1_RAT	P31390	CHEMBL4701	Histamine H1 Receptor, Rat	1
HRH2_CAVPO	P47747	CHEMBL2882	Histamine H2 Receptor, Guinea Pig	1
HRH2_RAT	P25102	CHEMBL4654	Histamine H2 Receptor, Rat	1
HRH3_RAT	Q9QYN8	CHEMBL4124	Histamine H3 Receptor, Rat	1
HRH4_RAT	Q91ZY1	CHEMBL4468	Histamine H4 Receptor, Rat	1
MCHR2_HUMAN	Q969V1	CHEMBL5038	Melanin-concentrating Hormone Receptor 2, Human	1
OPRM_RAT	P33535	CHEMBL270	Mu Opioid Receptor, Rat	1
Q63380_RAT	Q63380	CHEMBL6184	Transporter, Rat	1
S22A1_HUMAN	O15245	CHEMBL5685	Solute Carrier Family 22 Member 1, Human	1
SC6A3_BOVIN	P27922	CHEMBL2986	Dopamine Transporter, Bovin	1
SC6A3_MACFA	Q9GJT6	CHEMBL5032	Dopamine Transporter, Macfa	1
SC6A3_RAT	P23977	CHEMBL338	Dopamine Transporter, Rat	1
SC6A4_MOUSE	Q60857	CHEMBL4642	Serotonin Transporter, Mouse	1
SCN1A_HUMAN	P35498	CHEMBL1845	Sodium Channel Protein Type I Alpha Subunit, Human	1
SCN2A_HUMAN	Q99250	CHEMBL4187	Sodium Channel Protein Type II Alpha Subunit, Human	1
SCN3A_HUMAN	Q9NY46	CHEMBL5163	Sodium Channel Protein Type III Alpha Subunit, Human	1
SCN8A_HUMAN	Q9UQD0	CHEMBL5202	Sodium Channel Protein Type VIII Alpha Subunit, Human	1
TSPOB_HUMAN	B1AH88	CHEMBL5139	Peripheral-type Benzodiazepine Receptor, Human	1
TSPO_RAT	P16257	CHEMBL4552	Peripheral-type Benzodiazepine Receptor, Rat	1
Z100251	Z100251	CHEMBL612442	Monoclonal Antibody (mAb) 2E2	1
Z50796	Z50796	CHEMBL614874	Monkey	1
Z80334	Z80334	CHEMBL613828	NG108-15 (Neuroblastoma-glioma Hybrid Cells)	1