UCSF

Serotonin 1b (5-HT1b) Receptor, Human (935 Compounds)

Swissprot:
5HT1B_HUMAN
Stitch:
5HT1B_HUMAN
UniProt:
P28222
ChEMBL:
CHEMBL1898
Reactome:
REACT_19231
REACT_17064
PDB:
2G1X (DOCK)
HTR1B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 935 52 20 18
Binding ≤ 1μM 822 43 18 16
Functional ≤ 10μM 83 20 6 6

Reactome Network (2)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_17064 Serotonin receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 422
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 843
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 27
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 68
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 19
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 9
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 7
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 5
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 23
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 19
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 26
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 3
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 60
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 52
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 39
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 5
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 2
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 4
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 6
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 9

Serotonin receptors

Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 422
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 843
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 27
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 68
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 84
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 65
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 94
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 18
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 19
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 63
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 61
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 452 138 55 52

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
5HT1B-1-E Serotonin 1b (5-HT1b) Receptor (cluster #1 Of 2), Eukaryotic 1,381 178 69 67
5HT1B-2-E Serotonin 1b (5-HT1b) Receptor (cluster #2 Of 2), Eukaryotic 4 2 0 0
Uniprot Swissprot Chembl Description Number Shared
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 843
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 389
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 147
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 106
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 105
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 92
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 91
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 82
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 81
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 73
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 72
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 68
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 66
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 65
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 63
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 59
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 58
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 55
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 50
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 43
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 39
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 38
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 30
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 27
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 26
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 25
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 24
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 23
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 22
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 20
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 19
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 19
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 18
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 18
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 17
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 16
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 16
ADA1B_MESAU P18841 CHEMBL3122 Alpha-1b Adrenergic Receptor, Mesau 15
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 15
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 14
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 14
ERG_HUMAN P11308 CHEMBL1293191 Transcriptional Regulator ERG, Human 14
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 13
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 12
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 12
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 10
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 10
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 9
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 9
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 9
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 9
ADRB2_HUMAN P07550 CHEMBL210 Beta-2 Adrenergic Receptor, Human 9
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 9
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 8
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 8
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 8
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 8
SC6A9_HUMAN P48067 CHEMBL2337 Glycine Transporter 1, Human 8
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 7
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 7
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 7
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 6
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 6
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 6
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 6
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 6
ADRB1_HUMAN P08588 CHEMBL213 Beta-1 Adrenergic Receptor, Human 6
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 6
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 6
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 6
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 5
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 5
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 5
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 5
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 5
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 5
NISCH_HUMAN Q9Y2I1 CHEMBL3923 Nischarin, Human 5
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 4
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 4
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 3
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 3
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 3
CNR1_HUMAN P21554 CHEMBL218 Cannabinoid CB1 Receptor, Human 3
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 3
MT3_HUMAN P25713 CHEMBL1250357 Metallothionein-3, Human 3
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 3
NK2R_HUMAN P21452 CHEMBL2327 Neurokinin 2 Receptor, Human 3
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 3
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 2
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 2
5HT5A_MOUSE P30966 CHEMBL3597 Serotonin 5a (5-HT5a) Receptor, Mouse 2
AA2AR_HUMAN P29274 CHEMBL251 Adenosine A2a Receptor, Human 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ADA2A_MOUSE Q01338 CHEMBL4075 Alpha-2a Adrenergic Receptor, Mouse 2
ADA2A_PIG P18871 CHEMBL2350 Alpha-2a Adrenergic Receptor, Pig 2
ADA2B_MOUSE P30545 CHEMBL2405 Alpha-2b Adrenergic Receptor, Mouse 2
ADA2C_MOUSE Q01337 CHEMBL4826 Alpha-2c Adrenergic Receptor, Mouse 2
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 2
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 2
ADRB3_HUMAN P13945 CHEMBL246 Beta-3 Adrenergic Receptor, Human 2
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 2
EDNRA_HUMAN P25101 CHEMBL252 Endothelin Receptor ET-A, Human 2
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 2
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 2
HRH4_HUMAN Q9H3N8 CHEMBL3759 Histamine H4 Receptor, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
MC4R_HUMAN P32245 CHEMBL259 Melanocortin Receptor 4, Human 2
MCHR1_HUMAN Q99705 CHEMBL344 Melanin-concentrating Hormone Receptor 1, Human 2
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 2
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 2
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 2
NTR1_HUMAN P30989 CHEMBL4123 Neurotensin Receptor 1, Human 2
SC5A7_HUMAN Q9GZV3 CHEMBL4507 High-affinity Choline Transporter, Human 2
V1AR_HUMAN P37288 CHEMBL1889 Vasopressin V1a Receptor, Human 2
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50588 Z50588 CHEMBL373 Canis Familiaris 2
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 2
Z80094 Z80094 CHEMBL614558 CHO-MG (Ovarian Cells) 2
Z81247 Z81247 CHEMBL399 HeLa (Cervical Adenocarcinoma Cells) 2
5HT1D_MOUSE Q61224 CHEMBL4297 Serotonin 1d (5-HT1d) Receptor, Mouse 1
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 1
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 1
ACM5_RAT P08911 CHEMBL277 Muscarinic Acetylcholine Receptor M5, Rat 1
ADA2B_BOVIN O77700 CHEMBL3523 Alpha-2b Adrenergic Receptor, Bovin 1
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 1
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 1
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 1
AOFA_RAT P21396 CHEMBL3358 Monoamine Oxidase A, Rat 1
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1F_HUMAN O60840 CHEMBL5593 Voltage-gated L-type Calcium Channel Alpha-1F Subunit, Human 1
CAC1S_HUMAN Q13698 CHEMBL3805 Voltage-gated L-type Calcium Channel Alpha-1S Subunit, Human 1
GNRHR_HUMAN P30968 CHEMBL1855 Gonadotropin-releasing Hormone Receptor, Human 1
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 1
HRH2_CAVPO P47747 CHEMBL2882 Histamine H2 Receptor, Guinea Pig 1
HRH2_RAT P25102 CHEMBL4654 Histamine H2 Receptor, Rat 1
HRH3_RAT Q9QYN8 CHEMBL4124 Histamine H3 Receptor, Rat 1
HRH4_RAT Q91ZY1 CHEMBL4468 Histamine H4 Receptor, Rat 1
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 1
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 1
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 1
S22A1_HUMAN O15245 CHEMBL5685 Solute Carrier Family 22 Member 1, Human 1
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 1
SC6A3_MACFA Q9GJT6 CHEMBL5032 Dopamine Transporter, Macfa 1
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 1
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
TSPOB_HUMAN B1AH88 CHEMBL5139 Peripheral-type Benzodiazepine Receptor, Human 1
TSPO_RAT P16257 CHEMBL4552 Peripheral-type Benzodiazepine Receptor, Rat 1
Z100251 Z100251 CHEMBL612442 Monoclonal Antibody (mAb) 2E2 1
Z50796 Z50796 CHEMBL614874 Monkey 1
Z80334 Z80334 CHEMBL613828 NG108-15 (Neuroblastoma-glioma Hybrid Cells) 1