UCSF

Melanin-concentrating Hormone Receptor 1, Human (2,286 Compounds)

Swissprot:
MCHR1_HUMAN
Stitch:
MCHR1_HUMAN
UniProt:
Q99705
ChEMBL:
CHEMBL344
Reactome:
REACT_19231
REACT_18283
REACT_14819
PDB:
MCHR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,286 34 0 0
Binding ≤ 1μM 2,080 24 0 0
Functional ≤ 10μM 1,104 6 0 0

Reactome Network (3)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_18283 G alpha (q) signalling events Homo sapiens
REACT_14819 Peptide ligand-binding receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 44
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 1
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 15
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 22
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 60
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 1
NPY2R_HUMAN P49146 CHEMBL4018 Neuropeptide Y Receptor Type 2, Human 1
NPY4R_HUMAN P50391 CHEMBL4877 Neuropeptide Y Receptor Type 4, Human 1
NPY5R_HUMAN Q15761 CHEMBL4561 Neuropeptide Y Receptor Type 5, Human 18

G alpha (q) signalling events

Uniprot Swissprot Chembl Description Number Shared
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 6
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 15
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 27
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 4
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 33
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 10
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 60

Peptide ligand-binding receptors

Uniprot Swissprot Chembl Description Number Shared
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 60
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 1
NPY2R_HUMAN P49146 CHEMBL4018 Neuropeptide Y Receptor Type 2, Human 1
NPY4R_HUMAN P50391 CHEMBL4877 Neuropeptide Y Receptor Type 4, Human 1
NPY5R_HUMAN Q15761 CHEMBL4561 Neuropeptide Y Receptor Type 5, Human 18
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MCHR1_MOUSE Q8JZL2 CHEMBL4730 Melanin-concentrating Hormone Receptor 1, Mouse 99 1 0 0
MCHR1_RAT P97639 CHEMBL1075228 Melanin-concentrating Hormone Receptor 1, Rat 52 0 0 0
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 18 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MCHR1-1-E Melanin-concentrating Hormone Receptor 1 (cluster #1 Of 2), Eukaryotic 1,937 18 0 0
MCHR1-2-E Melanin-concentrating Hormone Receptor 1 (cluster #2 Of 2), Eukaryotic 441 17 0 0
Uniprot Swissprot Chembl Description Number Shared
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 188
Z80175 Z80175 CHEMBL614585 IMR-32 (Neuroblastoma Cells) 119
MCHR2_HUMAN Q969V1 CHEMBL5038 Melanin-concentrating Hormone Receptor 2, Human 60
MCHR1_RAT P97639 CHEMBL1075228 Melanin-concentrating Hormone Receptor 1, Rat 40
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 35
MCHR1_MOUSE Q8JZL2 CHEMBL4730 Melanin-concentrating Hormone Receptor 1, Mouse 34
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 27
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 22
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 22
NPY5R_HUMAN Q15761 CHEMBL4561 Neuropeptide Y Receptor Type 5, Human 18
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 15
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 7
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 6
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 4
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 4
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 3
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 2
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 2
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 2
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 2
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 2
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 2
CCKAR_RAT P30551 CHEMBL2871 Cholecystokinin A Receptor, Rat 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 2
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 1
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 1
CCR3_HUMAN P51677 CHEMBL3473 C-C Chemokine Receptor Type 3, Human 1
NPY1R_HUMAN P25929 CHEMBL4777 Neuropeptide Y Receptor Type 1, Human 1
NPY2R_HUMAN P49146 CHEMBL4018 Neuropeptide Y Receptor Type 2, Human 1
NPY4R_HUMAN P50391 CHEMBL4877 Neuropeptide Y Receptor Type 4, Human 1
NPY5R_RAT Q63634 CHEMBL2548 Neuropeptide Y Receptor Type 5, Rat 1
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 1
Z80088 Z80088 CHEMBL613853 CHO (Ovarian Cells) 1

Most Common Rings