UCSF

Sigma Opioid Receptor, Rat (1,157 Compounds)

Swissprot:
SGMR1_RAT
Stitch:
SGMR1_RAT
UniProt:
Q9R0C9
ChEMBL:
CHEMBL3602

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,157 146 42 57
Binding ≤ 1μM 962 104 37 52
Functional ≤ 10μM 33 4 2 2

Reactome Network (0)

UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 823 43 14 13
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1,873 230 56 56
SGMR1_MOUSE O55242 CHEMBL3465 Sigma Opioid Receptor, Mouse 205 11 8 7

Clustered By Gene (0)

Clustered By Organism (5)

Code Description Substances Purchasable Natural In Man
SGMR1-1-E Sigma Opioid Receptor (cluster #1 Of 6), Eukaryotic 3,485 332 79 95
SGMR1-2-E Sigma Opioid Receptor (cluster #2 Of 6), Eukaryotic 15 6 3 3
SGMR1-3-E Sigma Opioid Receptor (cluster #3 Of 6), Eukaryotic 135 9 7 4
SGMR1-4-E Sigma Opioid Receptor (cluster #4 Of 6), Eukaryotic 193 26 3 3
SGMR1-5-E Sigma Opioid Receptor (cluster #5 Of 6), Eukaryotic 1 1 1 0
SGMR1-6-E Sigma Opioid Receptor (cluster #6 Of 6), Eukaryotic 42 5 1 1
Uniprot Swissprot Chembl Description Number Shared
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 353
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 352
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 349
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 195
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 147
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 134
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 54
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 47
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 46
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 39
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 38
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 38
PCP_HUMAN P42785 CHEMBL2335 Lysosomal Pro-X Carboxypeptidase, Human 32
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 31
SC6A3_RAT P23977 CHEMBL338 Dopamine Transporter, Rat 30
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 29
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 28
OPRD_HUMAN P41143 CHEMBL236 Delta Opioid Receptor, Human 28
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 26
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 26
CCKAR_RAT P30551 CHEMBL2871 Cholecystokinin A Receptor, Rat 25
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 24
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 23
OPRD_MOUSE P32300 CHEMBL3222 Delta Opioid Receptor, Mouse 23
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 22
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 21
OPRK_MOUSE P33534 CHEMBL4329 Kappa Opioid Receptor, Mouse 20
OPRM_MOUSE P42866 CHEMBL2858 Mu Opioid Receptor, Mouse 19
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 18
SGMR1_MOUSE O55242 CHEMBL3465 Sigma Opioid Receptor, Mouse 18
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 17
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 14
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 13
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 13
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 13
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 13
5HT2A_BOVIN Q75Z89 CHEMBL3446 Serotonin 2a (5-HT2a) Receptor, Bovin 12
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 12
ADA1A_BOVIN P18130 CHEMBL4892 Alpha-1a Adrenergic Receptor, Bovin 12
ADA1B_HUMAN P35368 CHEMBL232 Alpha-1b Adrenergic Receptor, Human 12
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 12
ADA1D_HUMAN P25100 CHEMBL223 Alpha-1d Adrenergic Receptor, Human 11
VACHT_HUMAN Q16572 CHEMBL4767 Vesicular Acetylcholine Transporter, Human 11
VACHT_RAT Q62666 CHEMBL2125 Vesicular Acetylcholine Transporter, Rat 11
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 11
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 10
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 10
OPRM_CAVPO P97266 CHEMBL4354 Mu Opioid Receptor, Guinea Pig 10
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 9
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 9
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 9
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 9
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 9
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 9
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 8
5HT3B_MOUSE Q9JHJ5 CHEMBL3781 Serotonin 3b (5-HT3b) Receptor, Mouse 8
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 8
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 8
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 8
EBP_CAVPO Q60490 CHEMBL5525 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Guinea Pig 8
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 8
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 8
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 7
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 7
NMD3B_RAT Q8VHN2 CHEMBL282 Glutamate [NMDA] Receptor Subunit 3B, Rat 7
NMDE4_RAT Q62645 CHEMBL303 Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat 7
OPRM_BOVIN P79350 CHEMBL3041 Mu Opioid Receptor, Bovin 7
OPRX_RAT P35370 CHEMBL4503 Nociceptin Receptor, Rat 7
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 6
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 6
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 6
NMD3A_HUMAN Q8TCU5 CHEMBL4787 Glutamate [NMDA] Receptor Subunit 3A, Human 6
NMD3B_HUMAN O60391 CHEMBL2913 Glutamate [NMDA] Receptor Subunit 3B, Human 6
NMDE1_HUMAN Q12879 CHEMBL1972 Glutamate [NMDA] Receptor Subunit Epsilon 1, Human 6
NMDE2_HUMAN Q13224 CHEMBL1904 Glutamate [NMDA] Receptor Subunit Epsilon 2, Human 6
NMDE3_HUMAN Q14957 CHEMBL4109 Glutamate [NMDA] Receptor Subunit Epsilon 3, Human 6
NMDE4_HUMAN O15399 CHEMBL2591 Glutamate [NMDA] Receptor Subunit Epsilon 4, Human 6
NMDZ1_HUMAN Q05586 CHEMBL2015 Glutamate (NMDA) Receptor Subunit Zeta 1, Human 6
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 5
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 5
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 5
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 5
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 5
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 5
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 5
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 5
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 5
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 5
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 5
SCN1A_RAT P04774 CHEMBL4906 Sodium Channel Protein Type I Alpha Subunit, Rat 5
SCN2A_RAT P04775 CHEMBL3399 Sodium Channel Protein Type II Alpha Subunit, Rat 5
SCN3A_RAT P08104 CHEMBL4966 Sodium Channel Protein Type III Alpha Subunit, Rat 5
SCN8A_RAT O88420 CHEMBL2752 Sodium Channel Protein Type VIII Alpha Subunit, Rat 5
5HT1D_PIG P79400 CHEMBL4105 Serotonin 1d (5-HT1d) Receptor, Pig 4
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 4
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 4
ACM3_HUMAN P20309 CHEMBL245 Muscarinic Acetylcholine Receptor M3, Human 4
ACM5_HUMAN P08912 CHEMBL2035 Muscarinic Acetylcholine Receptor M5, Human 4
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 4
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 4
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 4
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 4
OPRX_HUMAN P41146 CHEMBL2014 Nociceptin Receptor, Human 4
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 3
5HT4R_CAVPO O70528 CHEMBL5017 Serotonin 4 (5-HT4) Receptor, Guinea Pig 3
5HT4R_HUMAN Q13639 CHEMBL1875 Serotonin 4 (5-HT4) Receptor, Human 3
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 3
5HT5A_HUMAN P47898 CHEMBL3426 Serotonin 5a (5-HT5a) Receptor, Human 3
5HT7R_HUMAN P34969 CHEMBL3155 Serotonin 7 (5-HT7) Receptor, Human 3
ACM4_HUMAN P08173 CHEMBL1821 Muscarinic Acetylcholine Receptor M4, Human 3
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 3
ADA2A_BOVIN Q28838 CHEMBL4744 Alpha-2a Adrenergic Receptor, Bovin 3
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 3
AOFB_HUMAN P27338 CHEMBL2039 Monoamine Oxidase B, Human 3
DRD2_MOUSE P61168 CHEMBL3427 Dopamine D2 Receptor, Mouse 3
GASR_RAT P30553 CHEMBL3508 Cholecystokinin B Receptor, Rat 3
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 3
NMDZ1_RAT P35439 CHEMBL330 Glutamate (NMDA) Receptor Subunit Zeta 1, Rat 3
VACHT_TORCA P81721 CHEMBL3313 Vesicular Acetylcholine Transporter, Torca 3
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 2
5HT3A_MOUSE P23979 CHEMBL4972 Serotonin 3a (5-HT3a) Receptor, Mouse 2
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 2
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 2
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 2
5HT3E_HUMAN A5X5Y0 CHEMBL3812 Serotonin 3e (5-HT3e) Receptor, Human 2
5HT6R_HUMAN P50406 CHEMBL3371 Serotonin 6 (5-HT6) Receptor, Human 2
A2AIR5_MOUSE A2AIR5 CHEMBL2562 Glutamate [NMDA] Receptor Subunit 3A, Mouse 2
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 2
AOFB_RAT P19643 CHEMBL2993 Monoamine Oxidase B, Rat 2
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 2
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 2
HRH3_CAVPO Q9JI35 CHEMBL5076 Histamine H3 Receptor, Guinea Pig 2
NMD3B_MOUSE Q91ZU9 CHEMBL2557 Glutamate [NMDA] Receptor Subunit 3B, Mouse 2
NMDE1_MOUSE P35436 CHEMBL2521 Glutamate [NMDA] Receptor Subunit Epsilon 1, Mouse 2
NMDE2_MOUSE Q01097 CHEMBL3442 Glutamate [NMDA] Receptor Subunit Epsilon 2, Mouse 2
NMDE3_MOUSE Q01098 CHEMBL3555 Glutamate [NMDA] Receptor Subunit Epsilon 3, Mouse 2
NMDE4_MOUSE Q03391 CHEMBL2893 Glutamate [NMDA] Receptor Subunit Epsilon 4, Mouse 2
NMDZ1_MOUSE P35438 CHEMBL2895 Glutamate (NMDA) Receptor Subunit Zeta 1, Mouse 2
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
Z50594 Z50594 CHEMBL375 Mus Musculus 2
5HT1A_MOUSE Q64264 CHEMBL3737 Serotonin 1a (5-HT1a) Receptor, Mouse 1
5HT2A_PIG P50129 CHEMBL2490 Serotonin 2a (5-HT2a) Receptor, Pig 1
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 1
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 1
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 1
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 1
ACM1_MOUSE P12657 CHEMBL3733 Muscarinic Acetylcholine Receptor M1, Mouse 1
ACM2_MOUSE Q9ERZ4 CHEMBL3197 Muscarinic Acetylcholine Receptor M2, Mouse 1
ACM3_MOUSE Q9ERZ3 CHEMBL5105 Muscarinic Acetylcholine Receptor M3, Mouse 1
ACM4_MOUSE P32211 CHEMBL4572 Muscarinic Acetylcholine Receptor M4, Mouse 1
ACM5_MOUSE Q920H4 CHEMBL2324 Muscarinic Acetylcholine Receptor M5, Mouse 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
AOFA_HUMAN P21397 CHEMBL1951 Monoamine Oxidase A, Human 1
AP2S1_RAT P62744 CHEMBL1697667 AP-2 Complex Subunit Sigma, Rat 1
CCKAR_HUMAN P32238 CHEMBL1901 Cholecystokinin A Receptor, Human 1
CCR5_MOUSE P51682 CHEMBL3676 C-C Chemokine Receptor Type 5, Mouse 1
CHLE_MOUSE Q03311 CHEMBL2528 Butyrylcholinesterase, Mouse 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_MOUSE Q61616 CHEMBL3071 Dopamine D1 Receptor, Mouse 1
DRD1_PIG P50130 CHEMBL5067 Dopamine D1 Receptor, Pig 1
DRD2_CHLAE P52702 CHEMBL5456 Dopamine D2 Receptor, Chlae 1
EPYC_HUMAN Q99645 CHEMBL2080 Small Chondroitin/dermatan Sulfate Proteoglycan, Human 1
GASR_HUMAN P32239 CHEMBL298 Cholecystokinin B Receptor, Human 1
GASR_MOUSE P56481 CHEMBL2854 Cholecystokinin B Receptor, Mouse 1
GBRA2_RAT P23576 CHEMBL341 GABA Receptor Alpha-2 Subunit, Rat 1
GRL1A_RAT Q91XQ4 CHEMBL3059 Glutamate [NMDA] Receptor-like 1A, Rat 1
HRH1_CAVPO P31389 CHEMBL3943 Histamine H1 Receptor, Guinea Pig 1
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 1
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 1
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 1
NMD3A_RAT Q9R1M7 CHEMBL342 Glutamate [NMDA] Receptor Subunit 3A, Rat 1
NMDE1_RAT Q00959 CHEMBL310 Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat 1
OPRD_PIG P79291 CHEMBL4103 Delta Opioid Receptor, Pig 1
OPRM_MACMU Q9MYW9 CHEMBL5799 Mu-type Opioid Receptor, Macmu 1
Q4U254_9ENTO Q4U254 CHEMBL2857 Human Rhinovirus A Protease, 9ento 1
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 1
Q72874_9HIV1 Q72874 CHEMBL243 Human Immunodeficiency Virus Type 1 Protease, 9hiv1 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
Q8WMX0_BOVIN Q8WMX0 CHEMBL2672 Muscarinic Acetylcholine Receptor M1, Bovin 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
Z104297 Z104297 CHEMBL1907603 Glutamate NMDA Receptor; GRIN1/GRIN2B 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1

Most Common Rings