UCSF

GABA-B Receptor 2, Human (32 Compounds)

Swissprot:
GABR2_HUMAN
Stitch:
GABR2_HUMAN
UniProt:
O75899
ChEMBL:
CHEMBL5034
Reactome:
REACT_75831
REACT_18319
REACT_19231
REACT_25031
REACT_25004
PDB:
GABBR2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 32 5 3 3
Binding ≤ 1μM 29 5 3 3
Functional ≤ 10μM 2 2 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_75831 Activation of G protein gated Potassium channels Homo sapiens
REACT_18319 Class C/3 (Metabotropic glutamate/pheromone receptors) Homo sapiens
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_25031 GABA B receptor activation Homo sapiens
REACT_25004 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32

Class C/3 (Metabotropic glutamate/pheromone receptors)

Uniprot Swissprot Chembl Description Number Shared
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32

G alpha (i) signalling events

Uniprot Swissprot Chembl Description Number Shared
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32

GABA B receptor activation

Uniprot Swissprot Chembl Description Number Shared
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Uniprot Swissprot Chembl Description Number Shared
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GABR2_RAT O88871 CHEMBL4686 GABA-B Receptor 2, Rat 59 25 6 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32 5 3 3

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
GABR2-1-E GABA-B Receptor 2 (cluster #1 Of 3), Eukaryotic 60 18 6 4
GABR2-2-E GABA-B Receptor 2 (cluster #2 Of 3), Eukaryotic 14 8 1 1
GABR2-3-E GABA-B Receptor 2 (cluster #3 Of 3), Eukaryotic 5 1 1 1
Uniprot Swissprot Chembl Description Number Shared
GABR1_HUMAN Q9UBS5 CHEMBL2064 GABA-B Receptor 1, Human 32
GABR1_RAT Q9Z0U4 CHEMBL2753 GABA-B Receptor 1, Rat 14
GABR2_RAT O88871 CHEMBL4686 GABA-B Receptor 2, Rat 14
Z104301 Z104301 CHEMBL1907607 GABA-A Receptor; Anion Channel 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 2
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 2
GBRA1_HUMAN P14867 CHEMBL1962 GABA Receptor Alpha-1 Subunit, Human 1
GBRA1_RAT P62813 CHEMBL343 GABA Receptor Alpha-1 Subunit, Rat 1
GBRA2_HUMAN P47869 CHEMBL4956 GABA Receptor Alpha-2 Subunit, Human 1
GBRA2_RAT P23576 CHEMBL341 GABA Receptor Alpha-2 Subunit, Rat 1
GBRA3_HUMAN P34903 CHEMBL3026 GABA Receptor Alpha-3 Subunit, Human 1
GBRA4_HUMAN P48169 CHEMBL2472 GABA Receptor Alpha-4 Subunit, Human 1
GBRA5_HUMAN P31644 CHEMBL5112 GABA Receptor Alpha-5 Subunit, Human 1
GBRA6_HUMAN Q16445 CHEMBL2579 GABA Receptor Alpha-6 Subunit, Human 1
GBRB1_HUMAN P18505 CHEMBL4558 GABA Receptor Beta-1 Subunit, Human 1
GBRB1_RAT P15431 CHEMBL334 GABA Receptor Beta-1 Subunit, Rat 1
GBRB2_HUMAN P47870 CHEMBL1920 GABA Receptor Beta-2 Subunit, Human 1
GBRB2_RAT P63138 CHEMBL295 GABA Receptor Beta-2 Subunit, Rat 1
GBRB3_HUMAN P28472 CHEMBL1847 GABA Receptor Beta-3 Subunit, Human 1
GBRB3_RAT P63079 CHEMBL316 GABA Receptor Beta-3 Subunit, Rat 1
GBRD_HUMAN O14764 CHEMBL3591 GABA Receptor Delta Subunit, Human 1
GBRE_HUMAN P78334 CHEMBL4635 GABA Receptor Epsilon Subunit, Human 1
GBRG1_HUMAN Q8N1C3 CHEMBL4044 GABA Receptor Gamma-1 Subunit, Human 1
GBRG1_RAT P23574 CHEMBL296 GABA Receptor Gamma-1 Subunit, Rat 1
GBRG2_HUMAN P18507 CHEMBL1788 GABA Receptor Gamma-2 Subunit, Human 1
GBRG3_HUMAN Q99928 CHEMBL2739 GABA Receptor Gamma-3 Subunit, Human 1
GBRP_HUMAN O00591 CHEMBL3506 GABA Receptor Pi Subunit, Human 1
GBRT_HUMAN Q9UN88 CHEMBL2843 GABA Receptor Theta Subunit, Human 1
S6A11_HUMAN P48066 CHEMBL5208 GABA Transporter 3, Human 1
S6A13_RAT P31646 CHEMBL4889 GABA Transporter 2, Rat 1
SC6A1_HUMAN P30531 CHEMBL1903 GABA Transporter 1, Human 1
SC6A1_RAT P23978 CHEMBL4054 GABA Transporter 1, Rat 1

Most Common Rings