UCSF

P-glycoprotein 1, Mouse (25 Compounds)

Swissprot:
MDR1_MOUSE
Stitch:
MDR1_MOUSE
UniProt:
P06795
ChEMBL:
CHEMBL3467
Reactome:
REACT_196555
REACT_237882

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 25 2 3 1
Binding ≤ 1μM 7 0 0 1
Functional ≤ 10μM 43 17 17 18

Reactome Network (2)

Reactome ID Description Species
REACT_196555 Abacavir transmembrane transport Mus musculus
REACT_237882 ABC-family proteins mediated transport Mus musculus
Uniprot Swissprot Chembl Description Number Shared
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 18

ABC-family proteins mediated transport

Uniprot Swissprot Chembl Description Number Shared
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 18
MRP1_MOUSE O35379 CHEMBL2532 Multidrug Resistance-associated Protein 1, Mouse 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 493 62 18 21
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MDR2_MOUSE P21440 CHEMBL2837 P-glycoprotein 2, Mouse 7 2 3 0
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 72 13 12 3

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
MDR1-1-E P-glycoprotein 1 (cluster #1 Of 3), Eukaryotic 232 29 10 9
MDR1-2-E P-glycoprotein 1 (cluster #2 Of 3), Eukaryotic 206 35 11 12
MDR1-3-E P-glycoprotein 1 (cluster #3 Of 3), Eukaryotic 77 0 0 0
Uniprot Swissprot Chembl Description Number Shared
MRP1_HUMAN P33527 CHEMBL3004 Multidrug Resistance-associated Protein 1, Human 32
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 20
MDR3_MOUSE P21447 CHEMBL2573 P-glycoprotein 3, Mouse 18
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 13
MDR2_MOUSE P21440 CHEMBL2837 P-glycoprotein 2, Mouse 7
ABCG2_HUMAN Q9UNQ0 CHEMBL5393 ATP-binding Cassette Sub-family G Member 2, Human 5
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 5
Z102121 Z102121 CHEMBL613162 Trichophyton Mentagrophytes 5
Z50408 Z50408 CHEMBL612841 Issatchenkia Orientalis 5
Z50426 Z50426 CHEMBL612856 Plasmodium Falciparum (isolate K1 / Thailand) 5
Z50442 Z50442 CHEMBL366 Candida Albicans 5
Z50443 Z50443 CHEMBL612647 Candida Glabrata 5
Z50452 Z50452 CHEMBL612649 Trichophyton Rubrum 5
MRP1_MOUSE O35379 CHEMBL2532 Multidrug Resistance-associated Protein 1, Mouse 4
Z50046 Z50046 CHEMBL612334 Trichophyton Quinckeanum 4
Z50409 Z50409 CHEMBL612842 Kluyveromyces Marxianus 4
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 4
Z81138 Z81138 CHEMBL613872 ScN2a (Scrapie-infected Neuroblastoma Cells) 4
CAC1C_RAT P22002 CHEMBL3762 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Rat 3
CAC1D_RAT P27732 CHEMBL4132 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Rat 3
Z50038 Z50038 CHEMBL612328 Plasmodium Yoelii Yoelii 3
Z50416 Z50416 CHEMBL363 Aspergillus Fumigatus 3
Z50459 Z50459 CHEMBL367 Leishmania Donovani 3
Z50594 Z50594 CHEMBL375 Mus Musculus 3
GRM6_HUMAN O15303 CHEMBL4573 Metabotropic Glutamate Receptor 6, Human 2
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 2
TRPA1_MOUSE Q8BLA8 CHEMBL1075310 Transient Receptor Potential Cation Channel Subfamily A Member 1, Mouse 2
Z50590 Z50590 CHEMBL613488 Sus Scrofa 2
Z80133 Z80133 CHEMBL614294 EMT6 (Mammary Carcinoma Cells) 2
CAC1B_HUMAN Q00975 CHEMBL4478 Voltage-gated N-type Calcium Channel Alpha-1B Subunit, Human 1
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 1
CAC1D_HUMAN Q01668 CHEMBL4138 Voltage-gated L-type Calcium Channel Alpha-1D Subunit, Human 1
CAC1G_HUMAN O43497 CHEMBL4641 Voltage-gated T-type Calcium Channel Alpha-1G Subunit, Human 1
CAC1H_HUMAN O95180 CHEMBL1859 Voltage-gated T-type Calcium Channel Alpha-1H Subunit, Human 1
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 1
P97706_RAT P97706 CHEMBL4957 Sodium Channel Protein Type VI Alpha Subunit, Rat 1
SCN5A_RAT P15389 CHEMBL3866 Sodium Channel Protein Type V Alpha Subunit, Rat 1
Z50274 Z50274 CHEMBL614955 Aspergillus Flavus 1
Z50275 Z50275 CHEMBL358 Aspergillus Niger 1
Z50380 Z50380 CHEMBL613088 Mycobacterium Smegmatis 1
Z50436 Z50436 CHEMBL365 Filobasidiella Neoformans 1
Z50444 Z50444 CHEMBL612868 Candida Parapsilosis 1
Z50446 Z50446 CHEMBL612870 Candida Tropicalis 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50512 Z50512 CHEMBL369 Cavia Porcellus 1
Z50587 Z50587 CHEMBL372 Homo Sapiens 1
Z50592 Z50592 CHEMBL374 Oryctolagus Cuniculus 1
Z80107 Z80107 CHEMBL614564 COS-7 (Kidney Cells) 1
Z80120 Z80120 CHEMBL614285 DLD-1 (Colon Adenocarcinoma Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80232 Z80232 CHEMBL614128 MCF7-VP 1
Z80362 Z80362 CHEMBL389 P388 (Lymphoma Cells) 1
Z80364 Z80364 CHEMBL614218 P388/ADR (Lymphoma Cells) 1
Z80532 Z80532 CHEMBL614774 T-24 (Bladder Carcinoma Cells) 1
Z80682 Z80682 CHEMBL392 A549 (Lung Carcinoma Cells) 1
Z80711 Z80711 CHEMBL613829 NCI/ADR-RES (Breast Carcinoma Cells) 1
Z80773 Z80773 CHEMBL614456 CHRC/5 Cell Line 1
Z80774 Z80774 CHEMBL614457 CHRC5 Cell Line 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 1
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 1
Z81008 Z81008 CHEMBL614788 Human Breast Cancer Cell Lines 1
Z81245 Z81245 CHEMBL614697 MDA-MB-435 (Breast Carcinoma Cells) 1