UCSF

Epoxide Hydratase, Human (966 Compounds)

Swissprot:
HYES_HUMAN
Stitch:
HYES_HUMAN
UniProt:
P34913
ChEMBL:
CHEMBL2409
Reactome:
REACT_150417
PDB:
1S8O (DOCK)
1VJ5 (DOCK)
1ZD2 (DOCK)
1ZD3 (DOCK)
1ZD4 (DOCK)
1ZD5 (DOCK)
3ANS (DOCK)
3ANT (DOCK)
3I1Y (DOCK)
3I28 (DOCK)
3KOO (DOCK)
3OTQ (DOCK)
3PDC (DOCK)
EPHX2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 966 92 3 3
Binding ≤ 1μM 876 77 3 3

Reactome Network (1)

Reactome ID Description Species
REACT_150417 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 70
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 7
CP2J2_HUMAN P51589 CHEMBL3491 Cytochrome P450 2J2, Human 9
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
HYES_MOUSE P34914 CHEMBL4140 Epoxide Hydratase, Mouse 146 25 0 2
HYES_RAT P80299 CHEMBL5669 Epoxide Hydrolase 2, Rat 258 7 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
HYES-1-E Epoxide Hydrolase 2 (cluster #1 Of 3), Eukaryotic 211 29 2 2
HYES-2-E Epoxide Hydrolase 2 (cluster #2 Of 3), Eukaryotic 717 68 1 2
HYES-3-E Epoxide Hydrolase 2 (cluster #3 Of 3), Eukaryotic 74 1 0 0
Uniprot Swissprot Chembl Description Number Shared
HYES_RAT P80299 CHEMBL5669 Epoxide Hydrolase 2, Rat 258
HYES_MOUSE P34914 CHEMBL4140 Epoxide Hydratase, Mouse 121
SCN5A_HUMAN Q14524 CHEMBL1980 Sodium Channel Protein Type V Alpha Subunit, Human 32
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 31
PGH2_HUMAN P35354 CHEMBL230 Cyclooxygenase-2, Human 13
CAC1C_HUMAN Q13936 CHEMBL1940 Voltage-gated L-type Calcium Channel Alpha-1C Subunit, Human 12
HYEP_HUMAN P07099 CHEMBL1968 Epoxide Hydrolase 1, Human 7
CP2J2_HUMAN P51589 CHEMBL3491 Cytochrome P450 2J2, Human 5
P95276_MYCTU P95276 CHEMBL1795155 Epoxide Hydrolase, Myctu 3

Most Common Rings