Names
Compounds (1,504)
Reactome (1)
Related By:
Pathway (1)
Organism (2)
Gene (1)
Org. Clust. (2)
ChEMBL (37)
Rings (50)

11-beta-hydroxysteroid Dehydrogenase 1, Human (1,504 Compounds)

Swissprot:: DHI1_HUMAN
Stitch:: DHI1_HUMAN
UniProt:: P28845
ChEMBL:: CHEMBL4235
Reactome:: REACT_11036
PDB:: 1XU7 (DOCK); 1XU9 (DOCK); 2BEL (DOCK); 2ILT (DOCK); 2IRW (DOCK); 2RBE (DOCK); 3BYZ (DOCK); 3BZU (DOCK); 3CH6 (DOCK); 3CZR (DOCK); 3D3E (DOCK); 3D4N (DOCK); 3D5Q (DOCK); 3EY4 (DOCK); 3FCO (DOCK); 3FRJ (DOCK); 3H6K (DOCK); 3HFG (DOCK); 3OQ1 (DOCK); 3PDJ (DOCK); 3TFQ (DOCK); HSD11B1

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,504	137	8	16
Binding ≤ 1μM	1,322	73	4	15

Reactome ID	Description	Species
REACT_11036	Glucocorticoid biosynthesis	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
3BHS2_HUMAN	P26439	CHEMBL3670	3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Human	1

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DHI1_MOUSE	P50172	CHEMBL3910	11-beta-hydroxysteroid Dehydrogenase 1, Mouse	587	47	3	8
DHI1_RAT	P16232	CHEMBL2391	11-beta-hydroxysteroid Dehydrogenase 1, Rat	37	1	1	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
DHI2_HUMAN	P80365	CHEMBL3746	11-beta-hydroxysteroid Dehydrogenase 2, Human	133	6	3	3

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
DHI1-1-E	11-beta-hydroxysteroid Dehydrogenase 1 (cluster #1 Of 3), Eukaryotic	1,350	127	3	13
DHI1-2-E	11-beta-hydroxysteroid Dehydrogenase 1 (cluster #2 Of 3), Eukaryotic	36	7	5	3
DHI1-3-E	11-beta-hydroxysteroid Dehydrogenase 1 (cluster #3 Of 3), Eukaryotic	166	10	0	3

Uniprot	Swissprot	Chembl	Description	Number Shared
DHI1_MOUSE	P50172	CHEMBL3910	11-beta-hydroxysteroid Dehydrogenase 1, Mouse	564
DHI2_HUMAN	P80365	CHEMBL3746	11-beta-hydroxysteroid Dehydrogenase 2, Human	127
DHI1_RAT	P16232	CHEMBL2391	11-beta-hydroxysteroid Dehydrogenase 1, Rat	37
DHI2_MOUSE	P51661	CHEMBL3490	11-beta-hydroxysteroid Dehydrogenase 2, Mouse	21
NR1I2_HUMAN	O75469	CHEMBL3401	Pregnane X Receptor, Human	8
DHB2_HUMAN	P37059	CHEMBL2789	Estradiol 17-beta-dehydrogenase 2, Human	5
DHB1_HUMAN	P14061	CHEMBL3181	Estradiol 17-beta-dehydrogenase 1, Human	4
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	2
PTN1_HUMAN	P18031	CHEMBL335	Protein-tyrosine Phosphatase 1B, Human	2
Q5XX84_CANFA	Q5XX84	CHEMBL5342	11-beta-hydroxysteroid Dehydrogenase Type 1, Canine	2
3BHS2_HUMAN	P26439	CHEMBL3670	3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Human	1
CAH12_HUMAN	O43570	CHEMBL3242	Carbonic Anhydrase XII, Human	1
CAH13_MOUSE	Q9D6N1	CHEMBL2186	Carbonic Anhydrase XIII, Mouse	1
CAH14_HUMAN	Q9ULX7	CHEMBL3510	Carbonic Anhydrase XIV, Human	1
CAH1_HUMAN	P00915	CHEMBL261	Carbonic Anhydrase I, Human	1
CAH2_HUMAN	P00918	CHEMBL205	Carbonic Anhydrase II, Human	1
CAH4_HUMAN	P22748	CHEMBL3729	Carbonic Anhydrase IV, Human	1
CAH5A_HUMAN	P35218	CHEMBL4789	Carbonic Anhydrase VA, Human	1
CAH5B_HUMAN	Q9Y2D0	CHEMBL3969	Carbonic Anhydrase VB, Human	1
CAH6_HUMAN	P23280	CHEMBL3025	Carbonic Anhydrase VI, Human	1
CAH7_HUMAN	P43166	CHEMBL2326	Carbonic Anhydrase VII, Human	1
CAH9_HUMAN	Q16790	CHEMBL3594	Carbonic Anhydrase IX, Human	1
DHI2_RAT	P50233	CHEMBL2908	11-beta-hydroxysteroid Dehydrogenase 2, Rat	1
DPOLB_RAT	P06766	CHEMBL4343	DNA Polymerase Beta, Rat	1
KPCL_HUMAN	P24723	CHEMBL3616	Protein Kinase C Eta, Human	1
PA21B_NAJME	P00599	CHEMBL3967	Phospholipase A2 Isozyme DE-I, Najme	1
PA2A_PROFL	P59264	CHEMBL5022	Phospholipase A2 Isozyme PLA-A, Profl	1
PA2GA_HUMAN	P14555	CHEMBL3474	Phospholipase A2 Group IIA, Human	1
PA2GD_HUMAN	Q9UNK4	CHEMBL4281	Group IID Secretory Phospholipase A2, Human	1
PA2GE_HUMAN	Q9NZK7	CHEMBL2154	Group IIE Secretory Phospholipase A2, Human	1
PA2GF_HUMAN	Q9BZM2	CHEMBL4278	Group IIF Secretory Phospholipase A2, Human	1
PTN11_HUMAN	Q06124	CHEMBL3864	Protein-tyrosine Phosphatase 2C, Human	1
PTN2_HUMAN	P17706	CHEMBL3807	T-cell Protein-tyrosine Phosphatase, Human	1
PYGM_RABIT	P00489	CHEMBL4696	Glycogen Phosphorylase, Muscle Form, Rabit	1
Q56D22_MACMU	Q56D22	CHEMBL5227	Hydroxysteroid 11-beta Dehydrogenase 1, Macmu	1
Q7T3S7_ECHCA	Q7T3S7	CHEMBL4195	Phospholipase A2, Echca	1
SC5A7_RAT	Q9JMD7	CHEMBL5797	High Affinity Choline Transporter 1, Rat	1