UCSF

Sphingosine 1-phosphate Receptor Edg-1, Human (487 Compounds)

Swissprot:
S1PR1_HUMAN
Stitch:
S1PR1_HUMAN
UniProt:
P21453
ChEMBL:
CHEMBL4333
Reactome:
REACT_19231
REACT_18365
PDB:
S1PR1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 487 13 7 2
Binding ≤ 1μM 451 12 7 2
Functional ≤ 10μM 170 3 1 0

Reactome Network (2)

Reactome ID Description Species
REACT_19231 G alpha (i) signalling events Homo sapiens
REACT_18365 Lysosphingolipid and LPA receptors Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 30
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 116
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 400
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 216
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 236

Lysosphingolipid and LPA receptors

Uniprot Swissprot Chembl Description Number Shared
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 30
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 116
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 400
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 216
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 236
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 116 4 2 0
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 317 5 4 1
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 206 5 4 0
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 207 8 6 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
S1PR1-1-E Sphingosine 1-phosphate Receptor Edg-1 (cluster #1 Of 2), Eukaryotic 429 8 3 3
S1PR1-2-E Sphingosine 1-phosphate Receptor Edg-1 (cluster #2 Of 2), Eukaryotic 68 10 7 0
Uniprot Swissprot Chembl Description Number Shared
S1PR3_HUMAN Q99500 CHEMBL3892 Sphingosine 1-phosphate Receptor Edg-3, Human 386
S1PR5_HUMAN Q9H228 CHEMBL2274 Sphingosine 1-phosphate Receptor Edg-8, Human 234
S1PR4_HUMAN O95977 CHEMBL3230 Sphingosine 1-phosphate Receptor Edg-6, Human 213
S1PR2_HUMAN O95136 CHEMBL2955 Sphingosine 1-phosphate Receptor Edg-5, Human 116
LPAR2_HUMAN Q9HBW0 CHEMBL3724 Lysophosphatidic Acid Receptor Edg-4, Human 30
SPHK1_HUMAN Q9NYA1 CHEMBL4394 Sphingosine Kinase 1, Human 1

Most Common Rings