UCSF

Metabotropic Glutamate Receptor 5, Human (523 Compounds)

Swissprot:
GRM5_HUMAN
Stitch:
GRM5_HUMAN
UniProt:
P41594
ChEMBL:
CHEMBL3227
Reactome:
REACT_18319
REACT_18283
PDB:
3LMK (DOCK)
GRM5

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 523 45 4 4
Binding ≤ 1μM 386 28 3 3
Functional ≤ 10μM 488 38 4 3

Reactome Network (2)

Reactome ID Description Species
REACT_18319 Class C/3 (Metabotropic glutamate/pheromone receptors) Homo sapiens
REACT_18283 G alpha (q) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 71
GRM2_HUMAN Q14416 CHEMBL5137 Metabotropic Glutamate Receptor 2, Human 7
GRM3_HUMAN Q14832 CHEMBL2888 Metabotropic Glutamate Receptor 3, Human 6
GRM4_HUMAN Q14833 CHEMBL2736 Metabotropic Glutamate Receptor 4, Human 2
GRM6_HUMAN O15303 CHEMBL4573 Metabotropic Glutamate Receptor 6, Human 4
GRM7_HUMAN Q14831 CHEMBL3777 Metabotropic Glutamate Receptor 7, Human 3
GRM8_HUMAN O00222 CHEMBL3228 Metabotropic Glutamate Receptor 8, Human 5

G alpha (q) signalling events

Uniprot Swissprot Chembl Description Number Shared
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 71
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 557 61 5 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 51 12 6 4
GRM2_HUMAN Q14416 CHEMBL5137 Metabotropic Glutamate Receptor 2, Human 293 14 4 3
GRM3_HUMAN Q14832 CHEMBL2888 Metabotropic Glutamate Receptor 3, Human 14 5 2 2
GRM4_HUMAN Q14833 CHEMBL2736 Metabotropic Glutamate Receptor 4, Human 137 45 3 3
GRM6_HUMAN O15303 CHEMBL4573 Metabotropic Glutamate Receptor 6, Human 4 3 1 1
GRM8_HUMAN O00222 CHEMBL3228 Metabotropic Glutamate Receptor 8, Human 5 3 1 1

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
GRM5-1-E Metabotropic Glutamate Receptor 5 (cluster #1 Of 5), Eukaryotic 177 19 1 1
GRM5-2-E Metabotropic Glutamate Receptor 5 (cluster #2 Of 5), Eukaryotic 548 48 2 1
GRM5-3-E Metabotropic Glutamate Receptor 5 (cluster #3 Of 5), Eukaryotic 245 7 0 0
GRM5-4-E Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic 9 3 2 2
GRM5-5-E Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic 38 4 0 0
Uniprot Swissprot Chembl Description Number Shared
GRM5_RAT P31424 CHEMBL2564 Metabotropic Glutamate Receptor 5, Rat 97
GRM1_HUMAN Q13255 CHEMBL3772 Metabotropic Glutamate Receptor 1, Human 71
GRM1_MOUSE P97772 CHEMBL2892 Metabotropic Glutamate Receptor 1, Mouse 15
GRM1_RAT P23385 CHEMBL4477 Metabotropic Glutamate Receptor 1, Rat 7
GRM2_HUMAN Q14416 CHEMBL5137 Metabotropic Glutamate Receptor 2, Human 7
GRM2_RAT P31421 CHEMBL2851 Metabotropic Glutamate Receptor 2, Rat 6
GRM3_HUMAN Q14832 CHEMBL2888 Metabotropic Glutamate Receptor 3, Human 5
GRM8_HUMAN O00222 CHEMBL3228 Metabotropic Glutamate Receptor 8, Human 5
GRM3_RAT P31422 CHEMBL3067 Metabotropic Glutamate Receptor 3, Rat 4
GRM6_HUMAN O15303 CHEMBL4573 Metabotropic Glutamate Receptor 6, Human 4
GRIA1_MOUSE P23818 CHEMBL3502 Glutamate Receptor Ionotropic, AMPA 1, Mouse 3
GRIA2_RAT P19491 CHEMBL3503 Glutamate Receptor Ionotropic, AMPA 2, Rat 3
GRIA3_RAT P19492 CHEMBL3504 Glutamate Receptor Ionotropic, AMPA 3, Rat 3
GRIA4_RAT P19493 CHEMBL3505 Glutamate Receptor Ionotropic, AMPA 4, Rat 3
GRIK1_RAT P22756 CHEMBL2919 Glutamate Receptor Ionotropic Kainate 1, Rat 3
GRIK2_RAT P42260 CHEMBL3607 Glutamate Receptor Ionotropic Kainate 2, Rat 3
GRIK3_RAT P42264 CHEMBL3744 Glutamate Receptor Ionotropic Kainate 3, Rat 3
GRIK4_RAT Q01812 CHEMBL3044 Glutamate Receptor Ionotropic Kainate 4, Rat 3
GRIK5_RAT Q63273 CHEMBL4041 Glutamate Receptor Ionotropic Kainate 5, Rat 3
GRM7_HUMAN Q14831 CHEMBL3777 Metabotropic Glutamate Receptor 7, Human 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
GRIA1_HUMAN P42261 CHEMBL2009 Glutamate Receptor Ionotropic, AMPA 1, Human 2
GRIA2_HUMAN P42262 CHEMBL4016 Glutamate Receptor Ionotropic, AMPA 2, Human 2
GRIA4_HUMAN P48058 CHEMBL3190 Glutamate Receptor Ionotropic, AMPA 4, Human 2
GRIK1_HUMAN P39086 CHEMBL1918 Glutamate Receptor Ionotropic Kainate 1, Human 2
GRIK2_HUMAN Q13002 CHEMBL3683 Glutamate Receptor Ionotropic Kainate 2, Human 2
GRIK3_HUMAN Q13003 CHEMBL3684 Glutamate Receptor Ionotropic Kainate 3, Human 2
GRIK5_HUMAN Q16478 CHEMBL2675 Glutamate Receptor Ionotropic Kainate 5, Human 2
GRM4_HUMAN Q14833 CHEMBL2736 Metabotropic Glutamate Receptor 4, Human 2
GRM4_RAT P31423 CHEMBL2787 Metabotropic Glutamate Receptor 4, Rat 2
GRM5_MOUSE Q3UVX5 CHEMBL1641352 Metabotropic Glutamate Receptor 5, Mouse 2
GRM6_RAT P35349 CHEMBL3842 Metabotropic Glutamate Receptor 6, Rat 2
GRM8_MOUSE P47743 CHEMBL4626 Metabotropic Glutamate Receptor 8, Mouse 2
GRM8_RAT P70579 CHEMBL2718 Metabotropic Glutamate Receptor 8, Rat 2
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 2
Z104297 Z104297 CHEMBL1907603 Glutamate NMDA Receptor; GRIN1/GRIN2B 2
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 2
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
AOFA_MOUSE Q64133 CHEMBL3681 Monoamine Oxidase A, Mouse 1
EAA3_HUMAN P43005 CHEMBL2721 Excitatory Amino Acid Transporter 3, Human 1
FOLH1_HUMAN Q04609 CHEMBL1892 Glutamate Carboxypeptidase II, Human 1
GRIA1_RAT P19490 CHEMBL3753 Glutamate Receptor Ionotropic, AMPA 1, Rat 1
GRIA2_MOUSE P23819 CHEMBL3205 Glutamate Receptor Ionotropic, AMPA 2, Mouse 1
GRIA3_MOUSE Q9Z2W9 CHEMBL3624 Glutamate Receptor Ionotropic, AMPA 3, Mouse 1
GRIA4_MOUSE Q9Z2W8 CHEMBL3615 Glutamate Receptor Ionotropic, AMPA 4, Mouse 1
GRM3_MOUSE Q9QYS2 CHEMBL3824 Metabotropic Glutamate Receptor 3, Mouse 1
GRM7_MOUSE Q68ED2 CHEMBL3966 Metabotropic Glutamate Receptor 7, Mouse 1
MURI_HELPY P56068 CHEMBL6078 Glutamate Racemase, Helpy 1
NMDE1_RAT Q00959 CHEMBL310 Glutamate [NMDA] Receptor Subunit Epsilon 1, Rat 1
NMDE2_RAT Q00960 CHEMBL311 Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat 1
NMDE3_RAT Q00961 CHEMBL401 Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat 1
NMDE4_RAT Q62645 CHEMBL303 Glutamate [NMDA] Receptor Subunit Epsilon 4, Rat 1
NMDZ1_RAT P35439 CHEMBL330 Glutamate (NMDA) Receptor Subunit Zeta 1, Rat 1
Q80T35_MOUSE Q80T35 CHEMBL3033 Metabotropic Glutamate Receptor 6, Mouse 1
Q80T43_MOUSE Q80T43 CHEMBL3779 Metabotropic Glutamate Receptor 2, Mouse 1
Q80T47_MOUSE Q80T47 CHEMBL2832 Metabotropic Glutamate Receptor 5, Mouse 1
XCT_HUMAN Q9UPY5 CHEMBL1075149 Cystine/glutamate Transporter, Human 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1

Most Common Rings