UCSF

Cell Division Control Protein 42 Homolog, Human (10 Compounds)

Swissprot:
CDC42_HUMAN
Stitch:
CDC42_HUMAN
UniProt:
P60953
ChEMBL:
CHEMBL6088
Reactome:
REACT_19238
REACT_21402
REACT_22351
REACT_12484
REACT_228085
REACT_24970
REACT_18407
REACT_1695
REACT_19342
REACT_160086
REACT_11051
REACT_19277
REACT_228166
PDB:
1A4R (DOCK)
1AJE (DOCK)
1AM4 (DOCK)
1AN0 (DOCK)
1CEE (DOCK)
1CF4 (DOCK)
1DOA (DOCK)
1E0A (DOCK)
1EES (DOCK)
1GRN (DOCK)
1GZS (DOCK)
1KI1 (DOCK)
1KZ7 (DOCK)
1KZG (DOCK)
1NF3 (DOCK)
2ASE (DOCK)
2DFK (DOCK)
2KB0 (DOCK)
2NGR (DOCK)
2ODB (DOCK)
2QRZ (DOCK)
2WM9 (DOCK)
2WMN (DOCK)
2WMO (DOCK)
3GCG (DOCK)
3N3V (DOCK)
CDC42

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 10 0 1 0
Binding ≤ 1μM 1 0 0 0

Reactome Network (13)

Reactome ID Description Species
REACT_19238 CD28 dependent Vav1 pathway Homo sapiens
REACT_21402 CDO in myogenesis Homo sapiens
REACT_22351 DCC mediated attractive signaling Homo sapiens
REACT_12484 EGFR downregulation Homo sapiens
REACT_228085 EPHB-mediated forward signaling Homo sapiens
REACT_24970 Factors involved in megakaryocyte development and platelet production Homo sapiens
REACT_18407 G alpha (12/13) signalling events Homo sapiens
REACT_1695 GPVI-mediated activation cascade Homo sapiens
REACT_19342 Inactivation of Cdc42 and Rac Homo sapiens
REACT_160086 Regulation of actin dynamics for phagocytic cup formation Homo sapiens
REACT_11051 Rho GTPase cycle Homo sapiens
REACT_19277 Sema4D induced cell migration and growth-cone collapse Homo sapiens
REACT_228166 VEGFA-VEGFR2 Pathway Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

DCC mediated attractive signaling

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

EPHB-mediated forward signaling

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 6

Factors involved in megakaryocyte development and platelet production

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

G alpha (12/13) signalling events

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 6

GPVI-mediated activation cascade

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

Inactivation of Cdc42 and Rac

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

Regulation of actin dynamics for phagocytic cup formation

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2

Sema4D induced cell migration and growth-cone collapse

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 6

VEGFA-VEGFR2 Pathway

Uniprot Swissprot Chembl Description Number Shared
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 6
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4 0 0 0
CDC7_HUMAN O00311 CHEMBL5443 Cell Division Cycle 7-related Protein Kinase, Human 223 5 0 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PKN2_HUMAN Q16513 CHEMBL3032 Protein Kinase N2, Human 6
ROCK2_HUMAN O75116 CHEMBL2973 Rho-associated Protein Kinase 2, Human 6
ROCK1_HUMAN Q13464 CHEMBL3231 Rho-associated Protein Kinase 1, Human 5
RAC1_HUMAN P63000 CHEMBL6094 Ras-related C3 Botulinum Toxin Substrate 1, Human 2
KGP2_HUMAN Q13237 CHEMBL2896 CGMP-dependent Protein Kinase 2, Human 1
KPCE_HUMAN Q02156 CHEMBL3582 Protein Kinase C Epsilon, Human 1